Rajesh Varma
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Adult-onset Still’s disease complicated with macrophage activation syndrome: A case report
No full textAdult-onset Still’s disease is a rare systemic disease while macrophage activation syndrome is a fulminant complication of Still’s disease. As mortality is high in macrophage activation syndrome, prompt diagnosis is crucial to commence definitive management. Adult-onset Still’s disease is a rare systemic disease while macrophage activation syndrome is a fulminant complication of Still’s disease. As mortality is high in macrophage activation syndrome, prompt diagnosis is crucial to commence definitive management. Macrophage activation syndrome is a complication of adult-onset Still’s disease. When first-line immunosuppressives fail, second-line medications including biologic therapy can be considered with good results. </p
New modalities of surgery for renal tumors in children: A Mini-Review
No full textNephroblastoma is one of the most frequent solid tumors in childhood. It is also a classical example of success in oncology achieved by consequent and randomized studies run since mid-XX until now. As systemic treatment is constantly very effective and has not changed markedly since the last 30 years, the development of precise imaging and surgical technique allowed for the introduction of several new operative methods offering intriguing advantages. This paper is based on the literature review limited to the state-of-the-art or corner-stone positions and over 30 years of personal experience of the author. It does not pretend to be a form of a systematic meta-analysis. </p
Relationship between gut microbiome and allergic asthma
No full textSince the late 20th century, environmental exposure to endotoxins has been very low and type I allergic disease has increased. In addition, we have increased exposure to PM2.5 and other chemicals. Recently, there is concern that the daily use of hygiene products containing antimicrobial substances is associated with an increased prevalence of allergies. It has been noted that these antimicrobial substances may exacerbate allergies. In our study, we confirmed that intratracheal administration of aqueous mite solution as an inhaled antigen and antimicrobial substance as an aggravating chemical induced much stronger allergic bronchial asthma in mice than in mice that received intratracheal mite solution alone. Thus, allergies have been found to be exacerbated by simultaneous exposure to both environmental antigens and man-made chemicals (adjuvants). Next, we analyzed 16S rRNA of the gut microbiota of triclosan-treated mice that developed an allergy. The bacterial gene abundance of 16S rRNA of Deltaproteobacteria, Erysipelotrichi and Clostridia was increased in a dose-dependent manner in triclosan-treated mice, while Bacteroides were decreased in these mice. The composition of the gut microbiota was altered after triclosan treatment and correlated with the exacerbation of asthmatic disease in these mice. In conclusion, because triclosan exacerbated the condition of allergic asthma in mice that inhaled mite antigens and were given triclosan to drink, and this condition was associated with an increase or decrease in certain bacteria in the gut, we suspect that if allergy sufferers continue to use triclosan, they will inhale dust mites and house dust on a daily basis, which may aggravate their allergy symptoms. Overall, the overuse of antimicrobials and preservatives in current daily life risks further increasing the number of allergic patients. The authors believe that it is time to rethink this lifestyle.</p
Physicochemical and antioxidant properties of Coffea arabica honey from Western Oromia, Ethiopia
No full textCoffea arabica is one of the most widely consumed and marketed commodities in the world. The study was designed to characterize C.arabica honey for botanical composition, physicochemical parameters, and antioxidant properties of honey. Twelve honey samples of C. arabica honey were collected during the flowering period of coffee flowers from the Zander hive. The physicochemical properties of honey and the Botanical origin of honey were determined based on Harmonized methods of the International Honey Commission. The antioxidant power of the coffee monofloral honey samples was determined by dissolving 1.5 gm of honey with 25 ml distilled water and mixing it with 25ml methanol and placed at 25◦C for sixty minutes of maceration using a temperature shaker. The pollen count percentage from honey indicated that all honey samples collected from Gera, Gomma, Yayu, and Manna districts were identified as coffee monofloral honey representing 84%, 93%, 75%, and 73 % of pollen count respectively. The mean moisture, ash, HMF, EC, FA, pH, fructose, glucose and sucrose content of Coffea arabica honey were 22.48%, 0.21%, 11.88, 0.49 mS/cm, 13.44 meq/Kg, 3.32, 32.77%, 32.9%, and 3.57% respectively. The total phenol and flavonoid content range from 42.1-82.1 and 21.7-59.7 mg/100 g of GAE/g respectively while the radical scavenging activity ranges from 60.2- 66.3%. The pollen analysis of honey from the area is coffee monofloral honey since its pollen count exceeds more than 45% and the honey quality also meets the Ethiopian and International standards. The antioxidant power of Coffee honey has a considerable amount of polyphenolics which have relevant antiradical activity.</p
The erosion/infiltration technique made by a polymer based on TEGDMA to mask the white lesions of the tooth
No full textIt is common to observe anterior teeth that present white opacities of enamel in relation to hypomineralization. These lesions alter social life of children and adults. There is a recent non-invasive treatment that can remove these stains without loss of substance, keeping tooth structure intact. This treatment modifies the optical properties of the white spot by infiltrating a polymer based on trimethylene glycol dimethacrylate (TEGDMA). This short article presents a method called erosion/ infiltration, which our team first described. Dentists must be aware of it, in order to treat patients with either fluorosis, MIH or trauma, so that much more invasive treatments such as veneers and crown can be avoided.</p
BIM methodology implementation in structural design: Adaptation of procedures and information management
No full textBuilding Information Modelling (BIM) is a methodology that accompanies technological evolution and consists of a set of processes and tools that allows the creation of a three-dimensional digital model. This model centralizes information, facilitating its access and exchange between the entities along the life cycle of a building.This study focuses on the application of BIM methodology within the framework of a structural design, identifying the benefits and limitations that it provides and indicating strategies that may be used to improve the quality of a project. A structural model was created through BIM-based platforms and then transferred to the calculation software where the structural analysis and design were carried out. After this, through the conceived digital model, various applications that it allows were explored, namely, the method of coordination and collaboration, detection of conflicts, production of drawings, the budget, and an immediate evaluation of the environmental impact of the structureThis study demonstrates a significant improvement in the quality of the structural design. Therefore, even though some limitations still exist, the implementation of this methodology is essential to improve the process in the AEC sector.</p
Review on Listeriosis in small ruminants and public health significance in Ethiopia
No full textListeria monocytogenes is a bacterium mostly transmitted to man through food and it can cause mild gastroenteritis or severe infections of the bloodstream and/or the central nervous system, or abortion, depending on host susceptibility. Listeriosis is a serious illness caused by eating food contaminated with the bacterium Listeria, which is a Gram-positive psychotropic, facultatively anaerobic, none sporulating, motile, small rod. It displays characteristic tumbling motility that is facilitated by the presence of peritrichous flagella. Motility is temperature-dependent, showing high motility at 20-30°C when the flagellar expression is maximum. L. monocytogenes is ubiquitous in the environment and can be found in soil, water, feces, silage, effluent foods, and sewage. It has the ability to form biofilms which can contribute to its ability to colonize food processing facilities. The primary mode of transmission for Listeria is through soil contamination and ingestion of contaminated feed. Calves that develop the septicemic disease may acquire infection from contamination of the cow teat from the ingestion of milk containing the organism or from a cow with subclinical bacteremia, through the navel from the environment and also as congenital infection. Infection with Listeria. monocytogenes usually follow ingestion of contaminated feed and may result in septicemia, encephalitis, and abortion. There are few clinical features that are unique to listeriosis. Therefore, clinicians must consider a variety of potential causes of infection, including viral infections (influenza) and other bacterial infections that may cause sepsis or meningitis. Cook thoroughly raw food from animal sources, such as beef, pork, or poultry. Wash raw vegetables thoroughly before eating. Keep uncooked meats separate from vegetables and from cooked foods and ready-to-eat foods. Avoid raw (unpasteurized) milk or foods made from raw milk. Wash hands, knives, and cutting board and can contact with before and after handling cooked foods.</p
Characterization and grading of Black Bengal goat skin based on coat color
No full textThe research was conducted to study physical parameters and histological structural patterns based on the coat color of Black Bengal goat skins. Five hundred skins were randomly selected, and measured using scientific instruments and the Haematoxylin-Eosin staining method was used for histological study. Black coat color skin was found the highest (58%), the mean weight, length, and width of Black Bengal goat skin was 998.80 gm, 29.24, and 20.91 cm, respectively but there were no significant differences among the groups. The mean thickness of the skin was 1.97, 1.43, and 1.96 mm in the butt, bell, and shoulder regions, respectively, and significantly different between the groups in all categories. All slaughtered goats were flayed using the “Muchki” (Hoisting and fisting) method. The average flay cut length, depth, and mechanical and parasitic damages were 20.2 mm, 1.50 mm, 6.11, and 1.50 %, respectively. No significant difference (p > 0.05) was found in inedible fleshing by-products, but significant differences (p < 0.05) were found in trimming by-products production and salt required for curing. Salted skins were preserved for an average of 3.5 days. Hair follicles, sebaceous glands, erector pili muscles, collagen fibers, and fiber bundles were more regular in the butt region than shoulder and belly regions in the black, brown, white, and mixed coat color of Black Bengal goat skins. </p
Epidemiological characteristics of patients diagnosed with dengue from 2015 to 2020 in Celaya, Guanajuato, México
No full textDengue is a viral disease transmitted by arthropods. It is caused by four Ribonucleic Acids (RNA) flavivirus serotypes (dengue virus [DENV] -1, -2, -3, and -4) which are transmitted by blood-feeding mosquitoes, primarily the Aedes aegypti mosquito. The infection causes flu-like symptoms and sometimes progresses to death.</p
Review of bacteriophage and its applications
No full textThe most prevalent and ubiquitous organisms in the world are bacteria-killing viruses called bacteriophages. The aim of this paper is to highlight some application areas of bacteriophages. There are both virulent and temperate bacteriophages in the environment, but only virulent bacteriophages are used for treatment, known as phage therapy. Since their discovery, bacteriophages have been considered a vital weapon to fight human and animal illnesses of bacterial origin. Currently, the emergence of growing microbial resistance to antibiotics and attention to bacteriophage use in treatment has all but grown up again. Correspondingly, the applications of bacteriophages for biocontrol purposes have become a remarkable opportunity in a number of fields, including farms and food production. Despite their treatment effects, bacteriophages also maintain a vital relationship with their hosts through moderating microbial populations and promoting their evolution by horizontal gene transfer. Additionally, they serve as vehicles for the transfer of vaccinations, the detection of dangerous microorganisms and systems for displaying proteins and antibodies. Bacteriophages are a varied collection of viruses that are simple to handle, making them suitable for use in treatments and biotechnology research. Hence, the expansion of various phage companies for phage production and the use of phage cocktails for the treatment of various bacterial diseases at different stages is recommended.</p