Rajesh Varma
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5017 research outputs found
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The effects of thymoquinone and cytozine arabinoside on apoptosis and cell proliferation in acute myeloide leukemia
No full textPurpose: The aim of this study was to investigate the effects of a chemotherapeutic agent Cytosine Arabinoside (Ara-C) and a natural anticancer agent of Thymoquinone (TQ) on apoptosis and cell proliferation of AML cell lines (Kasumi-6) both alone and in combined form.Material and method: Kasumi-6 AML cells were treated with three different doses of Ara-C (0.1, 0.5 and 1 µmol) and TQ (25, 50 and 100 µM) for 48 and 72 hours incubations. After Annexin V and Propidium Iodide (PI) staining, apoptosis, viability, and cell proliferation were evaluated for each group in flow cytometry.Results: As a result, AML cell lines showed a statistically significant difference in a single treatment of the active substances. Their combined treatment showed an increase in apoptosis and a decrease in viability in both groups at 48 and 72 hours incubation times (p < 0.001). In each group, it was observed that apoptosis was increased and viability was decreased and consequently cell proliferation was suppressed.Conclusion: Ara-C was used for the first time in this study with TQ in AML. It was determined that the combined use of TQ and Ara-C did not have a synergistic effect on apoptosis.</p
A review on silver nanoparticles focusing on applications in biomedical sector
No full textConsidering that nanosilver-based materials have shown to have a novel, demanding, and promising properties appropriate for a variety of biological applications, silver nanoparticles (AgNPs) have evolved into one of the most researched and examined nanostructures created from nanotechnology in recent years. Silver nanoparticles (AgNPs) have been the subject of research due to their special characteristics, and they have considerable interest in medical applications such as highly excellent antimicrobial agents even without toxic effects, and industrial applications such as inkjet inks comprising well-unified dispersions of nano-sized silver particles that are useful for creating electronic circuits. Due to the remarkable activities shown by silver nanoparticles, they have been the focus of many researchers for developing new medications with less toxic effects. In this study, we have highlighted some entitled applications of silver nanoparticles. This review will be helpful for the researchers working on silver nanoparticles. </p
New Rice (Oryza sativa L.) demonstration and popularization in Pawe district, Metekel zone, North Western Ethiopia
No full textRice is one of the millennium crops that give more attention by the government of Ethiopia to bring food security across the nation. Research has been conducted on rice and released promising rice varieties by Pawe agricultural research center in collaboration with Adet agricultural research center in the past. The objective of this demonstration was to popularize and demonstrate the newly released rice variety i.e. PSBRC92 and to get feedback from the end-users. In the field demonstration, a total of 50 rice producer farmers participated and they have given their own suggestions concerning the new rice variety compared with the check one. The advantages of using the new rice variety over the standard check are early maturity and high quality of resistance to diseases. Farmers’ agricultural experts and researchers were discussed fruitfully. Finally, farmers showed their interest to use the new rice variety, if they have got access to get the seed. Generally, all the stakeholders have agreed to do more to maximize and popularization of the new rice variety and the paper will provide some information to the readers about rice variety development research in Pawe as well as in Ethiopia.</p
Structural health monitoring and modal parameters identification of Mezcala Bridge
No full textSince 2016 the Instituto Mexicano del Transporte (Mexican Transport Institute) has continuously instrumented and performed the structural monitoring of the Mezcala Bridge, which is a cable-stayed bridge located in the State of Guerrero, Mexico. In order to identify early damage, several monitoring strategies based on changes in the bridge modal parameters have been implemented. To establish the limits of the parameters, such as the natural frequencies, damping ratios, and mode shapes, it is necessary to characterize the bridge dynamic behavior through monitoring information from the last 3 years, in order to analyze statistically every parameter and simulate different real damage scenarios. Modal parameters are calculated and evaluated every week or after accidents, earthquakes, or strong winds. Applying the proposed methodology based on the Enhanced Frequency Domain Decomposition (EFDD), the modal parameters of the Mezcala Bridge were efficiently estimated and monitored and subsequently, they could be used for finite element model development and calibration in order to evaluate the structural integrity of the bridge.</p
Oral rehabilitation of a patient with Sjögren syndrome
No full textSjögren syndrome (SS) is a chronic autoimmune disease characterized by inflammation of salivary and lacrymal glands, causing oral and ocular dryness [1]. The syndrome was named by Swedish ophthalmologist Henrik Sjögren, who identified it in 1933. </p
Review on milk production performance, challenges, and opportunities of dairy cows production in oromia regional state, Ethiopia
No full textThis review was conducted to review the information on milk production performance, challenges, and opportunities of dairy cattle production in Oromia. Supported management practices, marketing situations, feed sources, and feeding systems the foremost milk production systems are identified as rural milk production, peri-urban, and concrete milk production. Ethiopia holds large potential for dairy development mainly thanks to an acceptable environment and large cattle number that contains 65.35 million cattle populations. While there is a large milk cow population and favorable climatic conditions, self-sufficiency in milk production is low. The mean values of daily milk yield (DMY) range from 1 to2.8 liter/day with lactation length (LL) of 6.78 to 9.13 months for indigenous breeds, 6.5 to fifteen liters/day with lactation length of 7.52 to 11.67 months for crossbreed cows respectively. Both DMY and LL were significantly stricken by breed, parity, and year of calving. Challenges for dairying vary from one location to a distinct one. The foremost challenge that affects milk production performance of cattle in Oromia includes feed shortage, high feed cost, land shortage for farming of improved forage, insufficient veterinary services, no operational breeding strategy and policy, and low productivity of the indigenous cattle breeds are the foremost important factor limiting dairy products within the region. Therefore, to enhance these milk production performances of the dairy cow to determine genetic improvement policy, strategy, and breeding program and implement well management practices.</p
Effect of smoking on status of hearing: A cross-sectional study
No full textIntroduction: Smoking is a common tendency among all social classes around the globe, especially in the working population. Objective: To assess the significant link between tobacco and cigarette smoking and its effect on hearing among smokers as there is limited study on this aspect of the Indian population particularly with a high-frequency hearing threshold. Methodology: Cross-sectional study carried out on patients attending the OPD in ENT and Head & Neck Surgery Department of Rohilkhand Medical College & Hospital. The sample size came to be 90. Results: In smokers, there were 72 (80%) males and 18 (20%) females while in the non-smoker group, there were 53 (58.8%) males and 37 (41.11%) females, and 39 (43.3%) subjects belonging to the rural population while 51 (56.7%) subjects belong to an urban population. out of 90 subjects, 43 (30.3%) had cochlear deafness followed by 40 (28.2%) who had normal hearing and 7 (4.9%) had retrocochlear deafness. Conclusion: Tobacco has the power to reduce the ability to hear, mainly causing a sensorineural hearing loss at higher frequencies.</p
Review on the role of soil and water conservation practices on soil properties improvement in Ethiopia
No full textSoil erosion is one of several major deterioration processes which result in soil degradation and declining agricultural productivity in Ethiopia due to the dense population, high livestock density, and intensive crop production in the area. Soil and water conservation practices are one of the mechanisms used to reduce erosion and associated nutrient loss, reducing the risk of production. Therefore, the review focuses on the importance of soil and water conservation practices on soil properties in Ethiopia. Several studies conducted in various parts of the country showed that the implemented soil bund reduced annual runoff and soil loss at different rates. Soil and water conservation have improved the soil Physico-chemical properties on conserved cropland (BD, SMC, pH, CEC, av. K, av. P, SOC, and TN) compared to the adjacent cropland without soil and water conservation measures. Soil and water conservation, reduce the removal of fertile topsoil and improves soil moisture, which favors crop growth as a result grain yield of the crops was increased. In general, the use of soil and water conservation strategies had clearly shown a positive impact on soil physico-chemical properties and crop yields. Therefore, to reduce soil erosion sustainably, different soil and water conservation options should be introduced and used considering agroecology, socio-economic profile, and climatic condition of the intervention area.</p
Strengthen detection of raw milk somatic cell count - the first step for China milk quality improvement
No full textMilk is a healthy natural beverage and the main raw material of dairy products. It is well known that raw milk is the first link to guarantee and control the quality and safety of milk and dairy products. Only high-quality raw milk can produce high-quality dairy products.</p
Thinking in cytology key
No full textAs pathologists, cytotechnologists, and professors of pathology and cytology, we find ourselves disconcerted because we turn, in disbelief, to an unprecedented situation that could affect patient care and we refer to the exact opposite of that which could be considered in any medical treatise or scientific article from the 20th century.</p