Rajesh Varma
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Viral hepatitis B in patients with hematological malignancies (Overview)
No full textThe review presents current data on the role of viral hepatitis B in oncohematological patients. Possible ways of infection, prevention of infection, and activation of hepatitis B in this category of patients are considered. The specific features of the course of hepatitis B in various clinical situations are described: against the background of other viral infections and in the conduct of specific anti-leukemia therapy. </p
Wound healing by brand new product
No full textEggshell Membrane (ESM) has been used as an alternative natural bandage to cure wounds and is available in large quantities from egg industries. This study is based on the use of natural resources for skin tissue reconstruction. It needs to understand regeneration of tissue with Extracellular Matrix (ECM). Wound healing is a complicated and continuous recovery process of damaged tissues by replacing dysfunctional injured cellular structures. The wound healing process recruits some different phases: the first phase for hemostasis, the second phase for inflammation, the third phase for proliferation, and last phases for maturation/tissue remodeling. Each process needs an appropriate surrounding to achieve accelerated healing. Because the skin is in contact with the outside, injuries occur and therefore the surface is often injured. Due to the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair different skin lesions. We investigate the wound healing effects which are measured by dividing into the Exture® group, the commercially available wound dressing group (positive control), and the untreated group (negative control). We induced wounds and measured the healing process for 20 days for a comparison experiment of collagen membrane wound healing. As for the wound, the decrease in wound area using external photographs, the healing process within the tissue, and the immune response were measured through hematology analysis. We confirmed some differences through comparison of blood cell analysis and wound healing process but did not find statistical significance. There was no significant difference between treated collagen wound dressing film and commercial wound dressing film. Thus, this study reveals that the possibility of use natural source-based wound healing products brings sufficient wound healing results. </p
Bipolar disorder and aging
No full textBipolar disorder is a chronic illness, defined by a succession of depressive and/or manic periods separated by free intervals. Its evolution with aging is marked by a high suicide mortality rate. Bipolar disorders raise the question of their evolution when the age of the subject, in particular with regard to their frequency, their clinical characteristics, their prognosis and their management. The evolution of bipolar disorder with aging poses several difficulties in clinical practice due to its underestimated frequency and its misleading presentation and in particular by the presence of sometimes significant cognitive alterations leading sometimes to dementia.</p
A case of extremity over-exposure and regulatory compliance
No full textDuring a routine NRC inspection, a review of historical occupational dosimetry monitoring data for interventional radiology physician AUs was questioned regarding unexpectedly low results. This was interpreted to be an indicator of noncompliance with the wearing of occupational dose monitoring devices and, therefore, required occupation dose reconstructions in order to estimate the actual dose. In an effort to comply with dose monitoring requirements, the AU interventional radiologists diligently began wearing their whole-body and ring dosimeters during all procedures including Y-90, fluoroscopy-guided and CT-guided. In the interest of patient care, an AU that performs many interventional CT-guided procedures involving the use of a cumbersome treatment device, placed his hand in the CT beam on numerous occasions to stabilize the device. This quickly resulted in a cumulative extremity exposure that exceeded allowed limits. Once we became aware of the extremity over-exposure, steps were taken to prevent any further significant extremity exposure for the remainder of the year. The over-exposure was reported to the NRC and State following regulatory requirements. </p
Viscoelastic properties of alkaline treated walnut shell/rice straw fiber/epoxy biocomposite
No full textThe increasing demand for an eco-friendly environment has led to the recent development of polymer matrix/green plant fiber composites. In this present study, the viscoelastic performance of walnut/rice straw fiber/epoxy biocomposites was examined using a dynamic mechanical analysis (DMA) in three-point bending mode at a constant frequency (1 Hz) and temperature (25 oC to 240 °C). The surface morphology of the developed composites was analyzed using field emission scanning electron microscopy (SEM). The epoxy resin was incorporated with walnut/rice straw fiber in five proportions (2-10 wt%) using the hand lay-up technique. The hybrids of rice straw fiber/walnut shell ash particulates were added in equal ratios. The DMA results showed that epoxy/6wt% walnut/rice straw fiber biocomposite recorded the maximum storage modulus (> 8 × 103 MPa) with low loss modulus and damping factor. This indicates excellent stiffness and high energy storage capacity resulting from excellent interfacial bonding of molecules of epoxy, walnut shell particulates, and rice straw fiber. The epoxy/rice straw fiber biocomposite showed a high rate of molecular mobility, leading to high heat dissipation and damping capacity. The glass transition temperature (Tg) of the developed composites ranges from 70 oC to 130 oC, indicating the working temperature of the materials to be below 70 oC. The tan-δ curves indicate that walnut/rice straw fiber/epoxy biocomposites are heterogeneous materials with separate viscoelastic phases and glass transition temperatures, resulting from the addition of walnut shell particulates and rice straw fiber. These reinforcers are finally noted as critical factors affecting the extent of macromolecular mobility within walnut/rice straw fiber/epoxy biocomposites.</p
Fullerene and nanotube models in Bolyai - Lobachevsky hyperbolic geometry H3 on the 200th anniversary of its discovery
No full textThe Archimedean solid (5, 6, 6), where regular pentagon, hexagon and hexagon surround each vertex, so altogether 60 vertices (with carbon atoms for C60 fullerene). 12 pentagons and 20 hexagons bound this football polyhedron, as a regular (say white) icosahedron truncated by 12 (black) pentagons at its 12 vertices. </p
Ochoa syndrome: An overlooked diagnosis – A case report
No full textThe Urofacial Syndrome or Ochoa is a very rare clinical condition, and is unknown by a large part of the medical community; it is characterized by an inverted facial expression, resulting from abnormal contraction of facial and ocular muscles, especially when smiling, in addition to the presence of urinary abnormalities. Patients with this syndrome are at a higher risk of developing urinary incontinence, changes in the bladder, vesicoureteral reflux, hydroureteronephrosis, and predisposition to severe urinary infections, in addition to chronic kidney disease. This article presents a case of a 22-year-old female, resident of Piauí/Brazil, who presented at the age of 5, the first symptoms of the disease mainly related to the urinary tract (such as urinary frequency), in addition to the sign of inverted face, in which the patient presents the inverted smile characteristic of the disease when commanded to smile, associated with nocturnal lagophthalmos. The patient evolved at 12 years of age, with end-stage chronic kidney disease and a need for renal replacement therapy. This is one of the rare cases of the disease, in which the patient presents the complete characteristics of the inverted smile pathology and complications in the urinary tract. The inverted facial expression is an easily recognized sign, and it is a very characteristic finding of the disease, not finding explanations of morphological alterations or lesions. therefore, it is evident that early diagnosis with the institution of appropriate treatment, avoids possible damage to the urinary tract from childhood, allowing better management and quality of life in these patients. </p
Dietary intervention in enhancing immunity of cancer patients
No full textThe compromised function and environment of the immune system in individuals with cancer create a scenario in which the immune system fails to effectively identify and eliminate cancer cells. As a result, tumors can thrive and avoid detection by the immune system, leading to the progression of the disease. Gaining a comprehensive understanding of these immune-related challenges is essential for the development of effective cancer treatments, including immunotherapies, which aim to enhance the immune response against cancer. In addition to conventional treatments, dietary interventions have shown potential in supporting cancer patients by improving their immune function through nutritional support, influencing the gut microbiome, boosting the immune system, and other means. It is crucial to note that these dietary interventions should be tailored to each individual cancer patient, considering their specific requirements, preferences, and tolerances. This review seeks to underscore the significance of implementing well-adapted and appropriate dietary approaches to enhance the anticancer immunity of cancer patients.</p
Serial measurements of SIRS criteria to identify unique phenotypes of sepsis: A Microbiologic Approach
No full textIntroduction: The utility of serial scoring systems in identifying distinct sepsis phenotypes remains unknown.Methods: Eligible adults were classified into culture-positive (Cx+) and culture-negative (Cx-) groups alongside pre-defined culture subgroups. Average SIRS & SEP (novel scoring system) scores were calculated at t = 0 and hours 3,6,12 & 24 before and after t = 0. The primary outcome was a difference in SIRS/SEP scores amongst those that were Cx+ or Cx- at any time point. Secondary outcomes were comparing total and component SIRS/SEP scores in microbiologic subgroups over serial time points. Results: 4,701 Cx+ and 3254 Cx- patients met eligibility criteria. Statistically significant differences were seen in the average SIRS score between Cx + and Cx- groups at hours six (Cx+ 1.40+1.04 vs Cx- 1.35+1.01) & 12 (Cx+ 0.95+0.95 vs Cx- 0.90+0.90) after t = 0. The hematologic, urologic, and neurologic subgroups had significant differences at numerous time points before and after T = 0. Similar findings were observed with the SEP scores. Cx+ and Cx- groups (including subgroups) consistently doubled both SIRS/SEP scores before t = 0 with an eventual return to baseline values after T = 0 but at different gradients. Conclusion: Significant differences in SIRS/SEP scores were seen in Cx+ & Cx- patients at sequential time points. This microbiologic approach in homogenous culture cohorts has the potential to identify distinct phenotypes of sepsis efficiently and practically. Consistent increases in SIRS/SEP scores before t = 0 and sequential decreases after t = 0 may allow for early detection, intervention, and provision for real-time monitoring of therapeutic responses in patients with concerns for sepsis.</p
The impacts of poverty on hunger: An examination of the relationship between socioeconomic status and food insecurity
No full textHunger is a persistent global problem affecting billions of people worldwide, particularly those living in poverty and developing countries. Research work relates to experimental research work on the causes and effects of hunger and proposes potential solutions to address the problem. Poverty, conflict, natural disasters, climate change, and gender inequality are major drivers of hunger. Hunger leads to malnutrition, which impairs physical and cognitive development, reduces economic productivity, and undermines social stability. Addressing the underlying causes of hunger through policies that promote economic growth, sustainable agriculture, access to education and healthcare, social protection programs, and conflict resolution can create a world where everyone has access to adequate and nutritious food. By implementing a comprehensive and integrated approach, we can reduce hunger and ensure that it is no longer a barrier to economic and social development.This research was done to find out the solution to this issue. In the research work, I have studied data and analyzed it for the solutions. I have tried to present all the above concepts in a lucid way so as present the related concept in an effective manner.</p