Rajesh Varma
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5017 research outputs found
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Study on the mechanical properties of anisotropic red sandstone under point load strength test and uniaxial compression strength
No full textThe red sandstone of Xiaopu 3# branch Cave in the Yuxi section of the Central Yunnan Water Diversion Project was taken as the research object. The uniaxial compression strength and point load strength test are conducted from the perspectives of vertical and parallel stratifications, respectively, and then the anisotropy of red sandstone was analyzed in detail. The data obtained from the field and laboratory test was analyzed, and the conversion relationship between point load strength index and uniaxial compression strength is a power function under both parallel stratification and vertical stratification. The study results showed that: The mechanical properties of red sandstone have obvious anisotropy. The difference in its mechanical properties is particularly evident in UCS and point load tests and Is(50) and UCS under vertical stratification are significantly greater than Is(50) under parallel stratification. The point load strength correction index m of red sandstone is m = 0.4096 under parallel stratification, and m = 0.4408 under vertical stratification.</p
J/Ψ (1S) and Ψ (2S) Production in p-p Collisions at E=5.44 TeV
No full textI estimate the differential rapidity cross sections for J/Ψ and Ψ (2S) via pp (proton-proton) collisions at E=510 GeV. The J/Ψ is a standard charm quark and anti-charm quark, c and while Ψ (2S) is a mixed hybrid c meson. For the Ψ (2S) I use the mixed heavy quark hybrid theory, with states approximately 50% standard and 50% hybrid charmonium. </p
Quō Vādis theoretical physics and cosmology? from Newton’s Metaphysics to Einstein’s Theology
No full textThe crisis in modern theoretical physics and cosmology has its root in its use, along with theology as a ruling-class tool, since medieval Europe. The Copernican revolution overthrowing the geocentric cosmology of theology led to unprecedented social and scientific developments in history. But Isaac Newton’s mathematical idealism-based and on-sided theory of universal gravitational attraction, in essence, restored the idealist geocentric cosmology; undermining the Copernican revolution. Albert Einstein’s theories of relativity proposed since the turn of the 20th century reinforced Newtonian mathematical idealism in modern theoretical physics and cosmology, exacerbating the crisis and hampering further progress. Moreover, the recognition of the quantum world - a fundamentally unintuitive new realm of objective reality, which is in conflict with the prevailing causality-based epistemology, requires a rethink of the philosophical foundation of theoretical physics and cosmology in particular and of natural science in general. </p
Unveiling the draft genome sequence of diesel-degrading Paenibacillus sp. strain d9, a surfactant producer isolated from diesel-contaminated soil
No full textIntroduction: Gram-positive bacteria, particularly Bacillus and Paenibacillus spp., have gained significant attention for their potential in environmental bioremediation (biosurfactant production) and diverse biotechnological applications. Among these, Paenibacillus sp. D9, isolated from oil-contaminated soil, has shown diesel and engine oil degradation capabilities and biosurfactant production. However, its role in alkane degradation remains unexplored. Methodology and Result: To shed light on its unique attributes, we conducted whole-genome sequencing of Paenibacillus sp. D9 using the Illumina HiSeq 2000 platform. The draft genome comprised 56 contigs and 7 scaffolds, with a size of 5,645,302 bp at 157.94× coverage and a G + C content of 58.13%. A total of 9,950 Coding Sequences (CDSs) were predicted, and functional annotation revealed 3,283 (43.19%) and 3,155 (58.8%) putative genes based on Bacterial Annotation System (BASys) and Rapid Annotation using the Subsystems Technology (RAST) subsystem categorization, respectively. Furthermore, 93 tRNA and 23 rRNA genes were identified. Conclusion: This genome announcement provides valuable insights into the genetic potential of Paenibacillus sp. D9 and paves the way for future research in its biotechnological applications.</p
Using recombinant human G-CSF to treat chemotherapy-induced neutropenia over 3 decades: What is next?
No full textChemotherapy-Induced Neutropenia (CIN) is a potentially fatal side effect of cancer treatment, affecting > 50% of cancer patients treated with chemotherapy. Clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) has allowed for primary and secondary prophylaxis of CIN and its sequela (i.e., febrile neutropenia, fatal infection) during myelosuppressive chemotherapy. Here, we review the translation and properties of first, second, and third-generation rhG-CSF molecules, including filgrastim (Neupogen, FDA approved in 1991) and biosimilars, pegfilgrastim (Neulasta, FDA approved in 2002) and biosimilars, and F-627 (Ryzneuta, NMPA approved in 2023), a novel long-acting rhG-CSF agent developed this past decade. Even with the development of increasingly personalized and targeted cancer therapy, chemotherapy, and stem cell transplantation remains a backbone for the majority of patients with advanced cancers, especially in the hematopoietic system. As such, more than 20 million cancer patients have been treated with rhG-CSF drugs since the first approval of filgrastim. In the next decade, we envision third-generation rhG-CSF products such as Ryzneuta lowering costs to patients and healthcare providers, expanding access to this essential medication for cancer patients worldwide, particularly for patients who require more aggressive chemotherapy treatment. </p
Experimental and theoretical studies of the influence of the bench elements on the transient operation of the turbine
No full textThe energy parameters obtained during the tests of turbines of power units on the stand differ from those in the product. The research data, which results are presented in the materials of the paper, are aimed at analyzing the discrepancies between the parametric indicators of power units and bench tests of the turbines. The novelty of the obtained results reveals the direct and inverse relationship of changes in the amplitude-frequency characteristics of the elements of the stand (depending on the realized turbine power) with the obtained results of measuring the turbine power on the stand. We developed and described an algorithm for constructing dynamic analysis during the formation of the wave field of the test bench for turbines both in transient modes and in stationary modes corresponding to a constant number of turbine revolutions. It is shown that, by using the algorithm of modal deduction and conditions of dynamic excitation of vibrations from the tested turbine with elements of studying its power, it is possible to construct transients with certain reliability when the number of revolutions of the turbine changes, i.e. its power. The diagnostic model has a novelty since it allows not only to assess of the influence of the elements of the stand on the nature of the transient process when measuring turbine power in transient modes, taking into account the frequency adjustment when changing the revolutions of the turbine and the elements of the stand but also to form requirements for the frequency tuning of the stand. To clarify the transfer function of the "stand–turbine" system, a modal analysis was applied, which made it possible to clarify the structure of the transfer function in the frequency range of the natural (partial) frequencies of the elements of the stand when the restructuring of the wave field during the transient operation of the turbine, but also when the turbine reaches the specified power.</p
On Λ-fractional variational calculus
No full textPointing out that Λ-fractional analysis is the unique fractional calculus theory including mathematically acceptable fractional derivatives, variational calculus for Λ-fractional analysis is established. Since Λ-fractional analysis is a non-local procedure, global extremals are only accepted. That means the extremals should satisfy not only the Euler–Lagrange equation but also the additional Weierstrass-Erdmann corner conditions. Hence non-local stability criteria are introduced. The proposed variational procedure is applied to any branch of physics, mechanics, biomechanics, etc. The present analysis is applied to the Λ-fractional refraction of light. </p
The fractal analysis - Powerful tool for geodynamic investigations
No full textThis is a short review of fractal analysis applications in Bulgaria to investigate the geodynamics at the local, regional, and global levels.</p
A substance with negative mass
No full textThe conditions for the formation of a substance with a negative mass are investigated. The critical velocity of a body ω = 235696.8871 km/s, necessary for its transition to a massless state, was determined by two independent methods. Zeroing of the mass of matter also occurs at a temperature T =2.17 . 1036 mo (mo is the rest mass of the particle in grams). At higher temperatures or speeds of movement, the mass of bodies becomes negative. The resulting formulas made it possible to calculate the masses of X,Y-bosons equal to 4.606 . 10-9 g. The temperature of the Superunification of the four fundamental interactions, including gravity, is estimated to be 4.72 . 1031 K. </p
Prospects for environmentally safe disinfection of urban sewerage with the help of compositions of non-toxic bactericidal metal complex reagents and surfactants
No full textThe prospects of environmentally safe disinfection of urban sewerage using compositions of bactericidal complexes of copper with amino acids and iminodiacetate derivatives of mucopolysaccharides and triglycerides of fatty acids are shown. When they are dosed into wastewater, the complexes penetrate into the structure of Suspended Particulate Matter (SPM) and mucus and within a few minutes bind the structural fragments of pathogens and larvae, which leads to their death with the outflow of cell fluid, the disappearance of fecal odor, cessation of putrification and coagulation of SPM. The complete disinfection is achieved at doses of complexes of 0.8 - 1.5 mmol per 1 kg of dry matter. The composition is dosed into sewage wells. Organo-mineral masses settle from disinfected wastewater. The use of compositions will reduce the negative impact of sewerage on the sanitary-epidemiological and ecological situation in settlements, increase the efficiency of existing treatment facilities and produce organo-mineral masses as commercial products.</p