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Nuova Rottamazione Quinquies: Il Ddl AS 1375 rilancia la definizione agevolata dei debiti fiscali
No full textL’articolo analizza la nuova definizione agevolata dei carichi affidati alla riscossione, introdotta dal Ddl AS 1375 (c.d. rottamazione quinquies), che estende l’ambito temporale ai carichi dal 2000 al 2023 e introduce condizioni più flessibili rispetto alla precedente rottamazione quater. Tra le principali novità: piano di pagamento fino a 120 rate mensili, decadenza solo dopo 8 rate omesse e possibilità di riammissione per i decaduti dalla quater. Viene esaminato anche il potenziale ampliamento agli enti locali, il regime degli effetti sospensivi e le incertezze normative ancora da chiarire nel corso dell’iter parlamentare
Fostering climate change adaptation through local authority efforts: Insights from the case study of Genoa
Full text linkIn recent years, the adaptation of local communities to climate change has become a key priority
for policymakers. Local authorities, especially in urban areas, play a crucial role in implementing
adaptation policies to reduce climate-related risks. In this study, we investigated the development
of local adaptation processes in the area of Genoa, Italy, owing to its vulnerability and exposure to
risks that are expected to worsen in the near future. In particular, we investigated the contri bution of the regional, metropolitan, and municipal levels to local adaptation, thus identifying
which local authority exerts the maximum effort throughout the planning, implementation, and
monitoring phases. The analysis applied the UAST (Urban Adaptation Support Tool) as a meth odological framework. The results showed that achievement of a strong connection among
institutional levels, especially in terms of knowledge sharing and stakeholder involvement, can
significantly enhance adaptation outcomes. Conversely, when an integrated approach among
local authorities becomes flawed, the responsibility of implementing adaptation is unevenly
distributed among the concerned actors, and municipalities might play a major role. In particular,
we identified six main constraining factors that undermine local adaptation processes: i. Lack of
mandatory adaptation commitments at the sub-national levels; ii. Mismatched timeframes of
governments mandate and adaptation processes; iii. Delayed approval of a plan at the national
level; iv. Complexity of the multilevel policy framework; v. Complex variety of available policy
tools; vi. Lack of control, steering, and systematization of adaptation measures. Accordingly, we
close this study with some policy recommendations intended to foster the efficacy of local
adaptation
Nonlocal Mixed Systems With Neumann Boundary Conditions
No full textWe prove well posedness and stability in (Formula presented.) for a class of mixed hyperbolic–parabolic nonlinear and nonlocal equations in a bounded domain with no flow along the boundary. While the treatment of boundary conditions for the hyperbolic equation is standard, the extension to (Formula presented.) of classical results about parabolic equations with Neumann conditions is here achieved
Predictive value of left and right atrial strain for the detection of device-detected atrial fibrillation in patients with cryptogenic stroke and implantable cardiac monitor
No full textImplementation of a mathematical model for unsteady flow in irrigation channel networks with application to the case of management of Canale Vacchelli, Consorzio Irrigazioni Cremonesi
Full text linkA scala globale, il 70% dei prelievi di acqua è utilizzato in agricoltura; inoltre, la popolazione che basa il proprio sostentamento sui prodotti dell’agricoltura è in aumento. Tutto ciò in un contesto di conclamato cambiamento climatico. Da queste semplici considerazioni appare evidente come la gestione, il controllo e l’ottimizzazione della distribuzione dei volumi idrici in agricoltura abbia un’importanza fondamentale. In particolare, tale considerazione è rafforzata dal fatto che generalmente i Consorzi Irrigui sono istituzioni antiche che gestiscono la distribuzione delle risorse irrigue attuando soluzioni di «equilibrio» frutto dell’esperienza maturata negli anni, esperienza che potrebbe tuttavia rivelarsi non adatta alle condizioni future imposte dal cambiamento climatico. Uno strumento razionale e fisicamente basato che può essere d’aiuto nell’ottimizzazione del processo di distribuzione è fornito dalle Equazioni di Saint-Venant che, affiancato al ruolo del personale esperto, può rendere la gestione delle reti irrigue più efficiente. Il presente studio tratta dell’implementazione di un modello numerico che permetta di risolvere le equazioni di Saint-Venant nella formulazione monodimensionale per una rete di canali a pelo libero interconnessi tra loro secondo una topologia sufficientemente generale. Poiché un modello che abbia come obiettivo la modellazione di una rete irrigua deve integrare, mediante opportune condizioni al contorno interne, alcuni manufatti idraulici fondamentali, con i quali viene attuata la regolazione delle portate in ingresso alla rete irrigua e delle portate erogate ai canali secondari, tale componente costituisce un aspetto presente nel modello implementato. Inoltre, l’attività sperimentale svolta nell’ambito di questa Tesi ha consentito di constatare l’effetto del processo di crescita delle macrofite sulla scabrezza idraulica dei canali nel corso della stagione irrigua. La crescita e sviluppo della vegetazione è governata principalmente dalla radiazione solare, dalla presenza di nutrienti e dalla temperatura dell’acqua. Per tale ragione si è deciso di accoppiare al modello idraulico implementato, un modello termico che permetta di modellare la temperatura del corso d’acqua in tutto il dominio considerato e per l’intera stagione irrigua. Nella Tesi sono mostrati i passi percorsi per l’implementazione e validazione delle varie componenti descritte e l’applicazione delle stesse al Canale Vacchelli, il più importante canale gestito dal Consorzio Irrigazioni Cremonesi e uno dei più importanti in nord Italia.On a global scale, 70% of water withdrawals are used in agriculture; furthermore, the population that bases its livelihood on agricultural products is increasing. All this in a context of clear climate change. From these simple considerations it is clear that the management, control and optimization of the distribution of water volumes in agriculture has a fundamental importance. In particular, this consideration is strengthened by the fact that generally the Irrigation Consortia are ancient institutions that manage the distribution of irrigation resources by implementing "equilibrium" solutions resulting from the experience gained over the years, experience that could however not suitable for the future conditions imposed by climate change. A rational and physically based tool that can be of help in optimizing the distribution process is provided by the Saint-Venant Equations which, combined with the role of expert personnel, can make the management of irrigation networks more efficient. This study deals with the implementation of a numerical model that allows to solve the Saint-Venant equations in the one-dimensional formulation for a network of free-surface channels interconnected according to a sufficiently general topology. Since a model that has as its objective the modeling of an irrigation network must integrate, through appropriate internal boundary conditions, some fundamental hydraulic works, with which the regulation of the incoming flows to the irrigation network and of the flows delivered to the secondary channels is implemented, this component is present in the implemented model. Furthermore, the experimental activity carried out in the context of this Thesis has allowed to observe the effect of the growth process of macrophytes on the hydraulic roughness of the channels during the irrigation season. The growth and development of vegetation is mainly governed by solar radiation, the presence of nutrients and the temperature of the water. For this reason, it was decided to couple the implemented hydraulic model with a thermal model that allows modeling the temperature of the canal network for the entire irrigation season. This Thesis shows the steps taken for the implementation and validation of the various components described and their application to the Canale Vacchelli, the most important canal managed by the Consorzio Irrigazioni Cremonesi and one of the most important in northern Italy
Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base
Full text linkAim: The aim of this study was to compare the efficacy and safety of endoscopic endonasal approaches (EEA) with craniofacial resection (CFR) for sinonasal cancers invading the skull base, using an unanchored matching-adjusted indirect comparison (MAIC). Methods: A MAIC approach was used to analyse data from two large cohorts: the MUlti-institutional collaborative Study on Endoscopically treated Sinonasal cancers (MUSES) cohort, comprising sinonasal cancer patients treated endoscopically, and a historical CFR cohort reported by Ganly et al. Individual patient data were available only for the first cohort. Patients with olfactory neuroblastomas were excluded. Key prognostic factors were used to match and adjust the two cohorts, minimising selection bias. The primary endpoint was overall survival (OS), with secondary endpoints including recurrence-free survival (RFS), perioperative mortality, complication rates, and resection margins. Results: A total of 724 EEA-treated and 334 CFR-treated patients were included. EEA showed significantly improved OS before (HR= 2.33, 95 % CI= 1.88–2.87) and after MAIC adjustment (HR= 1.93, 95 % CI= 1.60–2.34). Observed RFS was higher in the EEA group (HR= 1.39, 95 % CI = 1.14–1.69) but no longer differed after adjustment (HR= 1.06, 95 % CI= 0.91–1.23). EEA was associated with significantly better Disease Specific Survival (HR= 1.71, 95 % CI = 1.39–2.13), lower perioperative mortality (OR= 8.12, 95 % CI= 3.45–36.7) and fewer complications than CFR (OR= 3.68, 95 % CI= 2.47–5.42). Conclusion: In this MAIC study based on the 2 largest cohorts of sinonasal cancer with skull base invasion, EEA offered comparable oncologic outcomes to CFR with reduced morbidity, supporting it as a valid alternative when performed in expert centres
Clinical features and surgical options of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A systematic review and a meta-analysis of prevalence
Full text linkBackground: OHVIRA syndrome, a urogenital malformation, lacks standardized management. Narrative reviews exist, but there is no a comprehensive meta-analysis. Objectives: The aim of this first systematic review and meta-analysis is to evaluate the current literature and inform management strategies. Search Strategy: We searched Scopus, Medline, Embase and Web of Science, up to March 2024. Selection Criteria: Case series, case reviews, and longitudinal studies on patients with OHVIRA syndrome. Data Collection and Analysis: Data were extracted and meta-analyzed using R software. Main Results: In all, 35 studies (1988–2022) with 526 patients were included. Average symptom onset was 14.45 years, and diagnosis at 16.36 years suggests potential delays. The most common symptoms were abdominal pain (67%, 95% CI 54–77, I2 = 66%) and dysmenorrhea (64%, 95% CI 55–72, I2 = 46%). Ultrasound (86%, 95% CI 76–92, I2 = 58%) and pelvic magnetic resonance imaging (61%, 95% CI 46–74, I2 = 72%) were primary imaging modalities. Hematocolpos (55%, 95% CI 42–67, I2 = 53%) and hematometra (53%, 95% CI 37–69, I2 = 70%) were frequent findings. Pelvic endometriosis, a major long-term complication, affected 20% of patients. Vaginal septum resection (83%, 95% CI 75–89, I2 = 48%) was the most common surgical treatment, often accompanied by laparoscopic endometriosis excision. Hysteroscopic septum resection emerged as a minimally invasive option (78%, 95% CI 46–93, I2 = 54%), with high success rate. Conclusions: Early diagnosis and surgery are crucial to prevent complications. Vaginal septum resection remains the gold standard, while hysteroscopy offers a promising minimally invasive alternative
Network Resilience and Sustainability: Renewable Energy-Based Solutions
Full text linkWith the increase in popularity of mobile services, radio access network (RAN) sustainability and resilience to power outages are becoming primary challenges. This article proposes to use power supply solutions based on renewable ener-gy sources (RESs) to jointly increase RANs' resil-ience and sustainability. We provide an overview of common RAN sustainability practices and pres-ent recent data on the increase in communication network failures. We discuss the concept of resil-ience in RANs, alongside the strategies and challenges of using RESs for power supply. Although RESs integration with RANs has been extensively studied in the literature for sustainability, the operational aspects before, during, and after emergen-cies remain unexplored. This article addresses this gap by evaluating the impact of RESs on the RAN sustainability and resilience through the use of real data from base station (BS) traffic load, grid power outages, and photovoltaic (PV) power production. Our findings show that integrating small PV panel capacities significantly reduces the carbon footprint of RANs, and it is crucial to maintain network operations during outages, especially during daylight hours when PV production is at its peak
Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart
No full textNew anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity. This scientific statement summarizes the preclinical models hitherto used, from in vitro two- and three-dimensional human systems to small and large animals, to pinpoint the molecular mechanisms behind the cardiotoxicity of new-generation anticancer therapies, particularly immunotherapies, and to develop potential cardioprotective strategies. Furthermore, it discusses how preclinical models have contributed to the provocative concept of heart failure being potentially tumorigenic and how the discovery of drugs with both anticancer and cardioprotective actions has revealed a common mechanistic basis for heart failure and cancer. Finally, it discusses the existing gaps between preclinical models and clinical observations in patients, how these discrepancies affect regulatory pathways and the drug development process in cardio-oncology and provides recommendations for closing these gaps
Manifestaciones
No full textStudio criminologico e di politica-criminale sulle manifestazioni della corruzione fra privati, con particolare riguardo alla sua fenomenologia in America Latina