Archivio istituzionale della ricerca - Università dell'Insubria
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Fenomenologia di un modesto “tafano”. Eloquenza, esercizio retorico e analisi concettuale nella didattica degli studi giuridici.
No full textIl contributo, strutturato formalmente e funzionalmente secondo le parti della tragedia identificate da Aristotele nella sua Poetica, si propone di valorizzare l’importanza dell’esercizio retorico
e critico-argomentativo nel percorso degli studi giuridici. A tal
fine, sulla scorta dell’esperienza varesina del corso di Filosofia
del diritto, viene presentato un percorso di approfondimento suddiviso in tre “episodi” e rivolto agli Studenti del primo anno di
Giurisprudenza: il Critone di Platone; il Discorso della servitù
volontaria di Etienne de La Boétie; la simulazione del Processo
di Norimberga di Carlos Nino
Cu-Doped Cs3Sb2Cl9Nanocrystals: Revisiting the Low Bandgap of Cs2CuSbCl6Double Perovskites
No full textLead-free halide double perovskite Cs2CuSbCl6nanocrystals have recently been reported to have a low bandgap of 1.66 eV. In this work, we show that the optical absorption spectra and X-ray diffraction patterns previously attributed to Cs2CuSbCl6can rather be explained with Cs3Sb2Cl9:Cu: X-ray absorption spectroscopy identifies [CuCl3]−trigonal pyramids, with Cu2+possibly replacing two Cs+sites. The broad low-energy optical absorption is then assigned to localized electronic transitions at copper dopants within the Cs3Sb2Cl9lattice, which do not affect the wide bandgap. Ab initio calculations suggest that Cs2CuSbCl6is thermodynamically unstable with respect to decomposition to Cs3Sb2Cl9, in line with the low reproducibility of Cs2CuSbCl6observed in its synthesis
Il Borghese e le arti visive negli anni di Longanesi (1950-1957)
No full textScholarly studies on the role of the multifaceted figure of Longanesi in the field of illustrated publishing have privi- leged the experiences of Il Selvaggio (approximately 1924- 1933) and Omnibus (1937-1939). Less investigated is his time at the head of Il Borghese, a magazine that Longanesi founded in 1950 and directed until his death with a policy of privileging artist graphics, starting from the cover. The contribution investigates the editorial choices regarding visual arts and the role played by the artists, first of all his friend Alberto Savinio, in the figuration of the periodical, with the aim of confirming the strategic and independent role of the image, in the latest editorial product conceived by the intellectual. A specific analysis will be dedicated to the iconographic and formal solutions of the years from 1950 to 1955, in which both graphic works by protagonists of the international artistic scene between the end of the 19th century and the first half of the 20th century were published (Munch, Toulouse-Lautrec, Chagall), and those of contemporary illustrators and designers (Steinberg), along- side color photography
Genetic variability of respiratory syncytial virus and its impact on monoclonal antibody binding sites: a national cross-sectional study during the 2023–2024 season
No full textBackground: Respiratory syncytial virus is a primary cause of acute lower respiratory tract infections globally. As preventive tools such as vaccines and monoclonal antibodies begin to enter clinical use, baseline genomic data are critical to evaluate their future impact and detect potential resistance-related mutations. The working group on respiratory viral infections (GLIViRe) conducted this multicenter study to characterize the genetic profile of RSV circulating in Italy during the 2023-2024 season, immediately prior to the introduction of immunoprophylactic interventions. The study focused on identifying mutations in the F protein at mAb binding sites for palivizumab, nirsevimab, RSM01, TNM-001, and clesrovimab. Methods: A total of 350 respiratory samples positive for RSV collected from patients with influenza-like illness (ILI) or acute respiratory infection (ARI), during the 2023-2024 season from 15 Italian laboratories were selected for sequence analysis. The F gene sequencing was performed on 287 RSV-A and 63 RSV-B samples using Sanger or next-generation sequencing. Phylogenetic analysis was conducted using IQ-TREE, with the integration of global data via NextStrain. Key mutations were mapped onto the F protein structure using ChimeraX and Protein Data Bank models. Shannon entropy was used to assess amino acid variability. Results: RSV-A samples predominantly belonged to the emerging A.D, A.D.1, and A.D.3 clades, while RSV-B samples mainly clustered in the B & sdot;D lineage. Key substitutions were detected at antigenic site & empty;, particularly at the nirsevimab and RSM01 interfaces. No changes occurred at the palivizumab/TNM-001 site II. All mutations of interest were exposed to the F protein surface. Conclusions: This study provides a critical genomic snapshot of RSV in Italy prior to the introduction of vaccines and mAbs. Continuous surveillance is essential for monitoring viral evolution and supporting the long-term effectiveness of future immunization strategies
Limiti alla discrezionalità degli Stati membri nella disciplina della cittadinanza: tanto rumore per una giurisprudenza costante?
No full textIl presente contributo prende le mosse dalla recente sentenza della Corte di giustizia dell’Unione europea Commissione c. Malta, per esaminare l’interazione fra le competenze esclusive statali nella disciplina della nazionalità e il riconoscimento della cittadinanza europea. Premesso il quadro del diritto internazionale, il lavoro esamina il complesso rapporto fra l’esclusività delle competenze statali e il rispetto del diritto dell’Unione europea. Quindi, ne valuta lo sviluppo con specifico riferimento all’elaborazione di criteri sulla cittadinanza, con particolare riferimento alla necessità di un collegamento effettivo e di fatto fra l’individuo e uno Stato alla luce del diritto dell’Unione europea. Quindi si offre un’interpretazione della sentenza Commissione contro Malta in un’ottica di continuità rispetto alla giurisprudenza pregressa. Le osservazioni finali sono dedicate alle conseguenze a breve termine – gli obblighi di Malta – e nel lungo periodo – la prospettiva di riforma del diritto della cittadinanza europea – della decisione
Quantum-Enhanced Second Harmonic Generation pumped by Parametric Down Conversion Beyond the Photon Pairs Regime
No full textWe demonstrate quantum-enhanced second harmonic generation driven by highly multimode parametric down conversion radiation, showing efficiency exceeding that of classical illumination up to intensities ten times the traditional quantum-classical boundary
Free flaps monitoring using implantable doppler: our experience and of the literature
No full textBackground: Buried free flaps monitoring cannot rely on clinical evaluation, which remains the gold standard in flaps with a skin paddle. A reliable way to monitor buried free flaps is through implantable dopplers, which provide a continuous and direct signal of anastomotic flow. Since the only way to ascertain a suspicion of vascular impairment in buried free flaps is through reoperative exploration, a high specificity is required together with a high sensitivity to avoid unnecessary theatre take-backs Methods: A systematic literature search was performed to screen three different databases (PubMed, Web of Sciences, and Embase) and using the following keywords: "Cook Swartz" AND "doppler" AND "flap" AND "monitoring" and "Synovis" AND "Flow Coupler" AND "flap" AND "monitoring". The indicators of efficacy and effectiveness of the two available implantable dopplers were analyzed and compared to our casistics. Results: The search using Cook Swartz thesaurus identified 116 articles while that of Synovis Flow Coupler 25 articles, of which only 26 and 6, respectively, fully satisfied our inclusion criteria. Conclusion: The literature search seems to confirm our current practice, with Cook Swartz (Cook Medical, Bloomington, IN) arterial placement preferred for head and neck buried free flaps and Synovis Flow Coupler (Synovis Life Technologies, Inc., St. Paul, MN) for buried DIEP flaps. This preferential placement reflects the higher rate of false positives when a vein is monitored in the head and neck, which is high mobile and prone to respiratory oscillations leading to probe dislocation or missing signal. (c) 2025 The Authors. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
Disease burden attributable to intimate partner violence against females and sexual violence against children in 204 countries and territories, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
No full textBackground: Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both national and global levels. Methods: We estimated the prevalence and attributable burden of IPV among females and SVAC among males and females for 204 countries and territories, by age and sex, from 1990 to 2023, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2023. We searched several global databases for data on self-reported exposure to IPV and SVAC and undertook a systematic review to identify the health outcomes associated with each of these risk factors. We modelled IPV and SVAC prevalence using spatiotemporal Gaussian process regression, applying data adjustments to account for measurement heterogeneity. We employed burden-of-proof methodology to estimate relative risks for outcomes associated with IPV and SVAC. These estimates informed the calculation of population attributable fractions, which were then used to quantify disability-adjusted life-years (DALYs) attributable to each risk factor. Findings: Globally, in 2023, we estimated that 608 million (95% uncertainty interval 518-724) females aged 15 years and older had ever been exposed to IPV, and 1·01 billion (0·764-1·48) individuals aged 15 years and older had experienced sexual violence during childhood. 18·5 million (8·74-30·0) DALYs were attributed to IPV among females and 32·2 million (16·4-52·5) DALYs were attributed to SVAC among males and females in 2023. IPV and SVAC were among the top contributors to the global disease burden in 2023, particularly among females aged 15-49 years, ranking as the fourth and fifth leading risk factors, respectively, for DALYs in this group. Among the eight health outcomes found to be associated with IPV, anxiety disorders and major depressive disorder were the leading causes of IPV-attributed DALYs, accounting for 5·43 million (-1·25 to 14·6) and 3·96 million (1·71 to 6·92) DALYs in 2023, respectively. SVAC was associated with 14 health outcomes, including mental health disorder, substance use disorder, and chronic and infectious disease outcomes. Self-harm and schizophrenia were the leading causes of SVAC-attributed burden, with SVAC accounting for 6·71 million (2·00 to 12·7) DALYs due to self-harm and 4·15 million (-1·92 to 13·1) DALYs due to schizophrenia in 2023. Interpretation: IPV and SVAC are substantial contributors to global health burden, and their health consequences span a variety of individual health outcomes. Importantly, mental health disorders account for the greatest share of disease burden among survivors. Investing in prevention of these avoidable risk factors has the potential to avert millions of DALYs and considerable premature mortality each year. Our findings represent strong evidence for global and national leaders to elevate IPV and SVAC among public health priorities. Sustained investments are needed to prevent IPV and SVAC and to implement interventions focused on supporting the complex social and health needs of survivors. Funding: Gates Foundation
When non-response makes estimates from a census a small area estimation problem: the case of the survey on graduates’ employment status in Italy
No full textSince 1998, AlmaLaurea—a consortium of 80 Italian universities and a member of the Italian National Statistical System—has conducted an annual census on graduates’ employment status. The survey provides estimates of descriptive indicators at both the population level and for specific subpopulations (domains) of interest, such as degree programmes. Some domains have very few observations due to a small population size and non-response. In this paper, we address this estimation problem within a Small Area Estimation framework. Specifically, we propose using generalized linear mixed models that incorporate two variables as proxies for graduates’ response propensity, making the assumption of non-informative non-response more plausible. Degree programme estimates of employment rates are derived as (semi-parametric) empirical best predictions using a finite mixture of logistic regression models, with their mean squared error estimated via a second-order, bias-corrected, analytical estimator. Sensitivity analysis is conducted to assess the explanatory power of variables modelling response propensity and to evaluate potential correlations between area-specific random effects and observed heterogeneity