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Dielectric Absorption Caused by Traps in MIM/MOS Capacitors: A New Model Validated Through TCAD
No full textWe propose here a flexible physics-based model to calculate the capacitance and conductance in MIM and MOS capacitors, accounting for traps with different energy and space distributions in the dielectric. The proposed model is validated against calibrated TCAD simulations. Furthermore, the frequency and temperature dependencies of the loss tangent obtained from the TCAD simulations have been analyzed and compared with experimental trends reported in the literature, highlighting their relation with the trap location in the oxide and the electron trapping process. These findings offer insight into the trap-induced effects in MIM capacitors, helping to determine the physical origin of the dielectric absorption (DA) phenomenon affecting relevant CMOS circuits such as analog-to-digital converters (ADCs)
Behavior-induced oscillations in epidemic outbreaks with distributed memory: beyond the linear chain trick using numerical methods
No full textWe consider a model for an infectious disease outbreak, when the depletion of susceptible is
negligible, and assume that individuals adapt their behavior according to the information they receive
about the new cases. In line with the information index approach, we assume that individuals react
to the past information according to a memory kernel that is continuously distributed in the past. We
analyze equilibria and their stability, with analytical results for selected cases. Thanks to the recently
developed pseudospectral approximation of delay equations, we study numerically the long-term dynamics of the model for memory kernels defined by Gamma distributions with general non-integer
shape parameter, extending the analysis beyond what is allowed by the linear chain trick. In agreement
with previous studies, we show that behavior adaptation alone can cause sustained waves of infections
even in an outbreak scenario, and notably in the absence of other processes like demographic turnover,
seasonality or waning of immunity. Our analysis gives a more general insight into how the period and
peak of the epidemic waves depend on the shape of the memory kernel and how the level of minimal
contact (essential service) impacts on the stability of the behavior-induced positive equilibrium
Characterization of Extracellular Vesicles from Cell Suspension Cultures of Coffea arabica L.
No full textA protocol was developed for the isolation and characterization of extracellular vesicles (EVs) from Coffea arabica cell suspension cultures (CSCs). The isolation method involved differential ultracentrifugation of the CSC filtrate, yielding two fractions: the pellet after 100,000×g for 36 min (100k×g) and the pellet obtained from the previous supernatant after 125,000 g for 6 h (125k×g). Both fractions were characterized by size, morphology, and proteomic profiles (ProteomeXchange identifier PXD071909). While no significant differences in average EV size were observed between the two fractions, proteomic analysis revealed distinct quantitative and compositional variations. The 100k×g fraction was enriched in proteins associated with cell periphery, plasma membrane, and extracellular region, whereas the 125k×g fraction predominantly contained proteins from the extracellular region. Proteomic marker analysis confirmed that both fractions contained protein EV markers, such as transmembrane and transport proteins, soluble EV-associated proteins, and proteins targeted to the extracellular environment or cell wall. Conversely, negligible contamination from non-EV-related proteins was detected. Furthermore, transmission electron microscopy (TEM) showed that the average size of the fractions was consistent with that reported for plant EVs. These findings demonstrate that the protocol utilized to isolate EVs from coffee CSC applies to the release of such vesicles without mechanical harsh grinding that leads to tissue/cell rupture and consequent contamination by other cell components. EVs obtained from coffee CSC represent a valuable and scalable platform, paving the way for the development of tools for biotechnological applications
On the Syntax of Pronominal Arguments of Infinitive Verbs in Saurian
No full textThis study investigates the syntactic positioning of object pronouns (personal and reflexive) in Saurian, a Southern-Bavarian variety spoken in Sauris/Zahre, Friuli, Italy. The focus is on com-plex predicate structures involving modal or functional verbs and non-finite clauses. A word order pattern is identified where pronominal arguments attach in enclisis to the infinitive verb. This configuration deviates from standard German and instead converges with Romance lan-guages. Besides this pattern, Saurian also displays a word order where pronominal arguments occur after the inflected within a verbal complex. The article investigates the two structures with respect to different functional verbs. Drawing on historical attestations and contemporary fieldwork data, the article argues that despite the prima facie convergent patterns, contact has at emost reinforced already existing structures in the receiving language in line with general norms that constrain crosslinguistic variation
Beyond technical feasibility: rethinking renal replacement therapy in children with profound medical complexity
No full textMobile Robotics for Forest Monitoring and Mapping Within the AI4FOREST Project
No full textIn this paper, we present the results of the development of an autonomous mobile robot for forest monitoring and mapping within the AI4FOREST project. This research project funded by the Italian National Recovery and Resilience Plan aims to design and implement an autonomous robotic system capable of navigating into a forest to create a digital twin of the environment and estimate the tree parameters. The proposed system is built on a Scout 2.0 wheeled mobile robot by AgileX that integrates a simultaneous localization and mapping approach for autonomous navigation and 3D reconstruction of the forest. Furthermore, the mobile robot is capable of detecting trees and estimating their diameters from point cloud data and a vision-based deep learning architecture. Experimental results in a wooded area demonstrate the capability of the robot for autonomous forest monitoring and mapping
Corrigendum to “International expert consensus on the clinical integration of circulating tumor cells in solid tumors”(European Journal of Cancer, (2025), 231, C, (116050), (S0959804925009360), 10.1016/j.ejca.2025.116050)
No full textThe authors regret an error in the affiliation for the author Maria Jose Serrano The authors would like to apologise for any inconvenience caused. Maria Jose Serranoe,veLiquid biopsy and Cancer Interception Group, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government (GENyO) - Institute for Biomedical Research (ibs.GRANADA), Granada, Spain. vPathological Anatomy Unit, Molecular Pathology Laboratory, Virgen de las Nieves University Hospital, Granada, Spain
Pulmonary valve replacement with a sutureless bioprosthesis
No full textSutureless bioprostheses are frequently used for aortic valve replacement (AVR), but their use for pulmonary valve replacement (PVR) has rarely been reported so far. We have recently observed a patient with aortic valve stenosis and dilatation of the ascending aorta in whom a high transpulmonary valve gradient was found due to severe dysplasia of the pulmonary valve PVR was performed with a Perceval sutureless bioprosthesis, along with aortic valve and ascending aorta replacement. This case stimulated a review of the literature to evidence similar cases previously published. Besides the present case, four other patients have been reported in the literature of PVR with a sutureless bioprosthesis. Clinical and technical details are reported, underlining the main differences in device implantation compared toe AVR. The present review confirms that PVR with a sutureless bioprosthesis is safe and feasible, with excellent results in various clinical scenarios, and it may be considered a valid alternative to transcatheter techniques
Clinical, toxicity and long-term neurocognitive outcomes of first-line intensive chemotherapy in infant medulloblastoma: a single-center cohort study following AIEOP recommendations
No full textPurpose: The long-term neurocognitive impact of craniospinal irradiation (CSI) in young children with medulloblastoma (MB) has driven the development of alternative strategies aimed at improving survival while delaying or avoiding CSI. Methods: We retrospectively analyzed a cohort of patients under 5 years of age with MB treated at Bambino Gesù Children’s Hospital between 2007 and 2023 with intensive chemotherapy regimens according to AIEOP recommendation. Clinical, radiological, histopathological, molecular, neurocognitive, and toxicity data were collected. Results: Among 42 patients under 5 years, 25 met inclusion criteria (median age 25.3 months, range 5.0–51.3). Histology included classic (52%), desmoplastic/nodular (20%), extensive nodularity (16%), and large cell/anaplastic (12%). SHH was the most common molecular subgroup (52%), followed by Group 3 (32%) and Group 4 (16%). At a median follow-up of 95.7 months, 68% were alive in complete remission. Two- and 5-year overall survival (OS) were 80.0% (95%CI: 58.4–91.1) and 65.9% (95%CI: 42.8–81.4); progression-free survival (PFS) was 68.0% (95%CI: 46.1–82.5) and 63.8% (95%CI: 41.8–79.2). Survival differed by risk group: low-risk patients achieved 100% OS and PFS, standard-risk intermediate, high-risk lowest. All experienced grade 3–4 hematological toxicity; late endocrine effects occurred in four patients, no other long-term toxicities reported. median IQ was stable from diagnosis (885.3) to last follow-up (8392.5.4). Conclusion: Our retrospective study of infants MB treated with first-line intensive chemotherapy shows encouraging survival rates. Importantly, neurocognitive function was preserved over time, supporting radiation-sparing strategies, and toxicity was manageable in all cases
Turbulent emulsions of hydrophilic and lipophilic surfactants
No full textWe investigate the adsorption of hydrophilic and lipophilic surfactants in turbulent oil-in-water emulsions