University of Udine
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La tradition manuscrite du Devisement dou monde de Marco Polo et les études de critique textuelle en Italie au XXe siècle [The manuscript tradition of Marco Polo’s Devisement dou monde and studies of textual criticism in Italy in the 20th century]
No full textThe Devisement dou monde is one of the most successful works of medieval Romance literature, with 144 manuscripts surviving to the present day. The scholarly debate over its textual tradition, which began in the nineteenth century, provides valuable insights into the development of philology in Italy. The identification of the key stages in the text’s transmission is due to Luigi Foscolo Benedetto (1886–1966), who published the first—and to date, only—critical edition of this travel account in 1928. The systematic classification of the manuscripts enabled him to demonstrate that the original version, written by Marco Polo in collaboration with Rustichello da Pisa during their imprisonment in Genoa in 1298, was composed in Franco-Italian. Benedetto’s edition is rightly regarded as one of the great achievements of twentieth-century Italian philology. His recensio is based on the assumption of a bipartite tradition. The branch containing the majority of surviving manuscripts (referred to as “A”) would transmit a version lacking certain original details, which would appear to be preserved in the other branch, designated “B.” The foundation of Benedetto’s 1928 edition has been widely accepted by scholars. However, over the past fifty years, researchers have increasingly questioned this framework, allowing for a more refined analysis of the relationships among manuscripts in the highest positions of the stemma codicum than Benedetto had achieved. Most notably, his initial assumption that authorial variants did not exist has been disproven. Current scholarship suggests that the version transmitted by the “A” branch reflects the form of the text produced in Genoa in 1298, while the additional material in the so-called “B group” was likely added by Marco Polo after his return to Venice
Advancing glioblastoma therapy with surface-modified nanoparticles
No full textBackground: Glioblastoma multiforme (GBM) is a very aggressive and deadly brain tumor, presenting considerable therapeutic hurdles due to its infiltrative development, heterogeneity, and protective mechanisms of the blood-brain barrier (BBB). Traditional treatment methods frequently do not yield satisfactory results, requiring the implementation of novel solutions. Surface-modified nanoparticles (NPs) have emerged as a viable approach in GBM therapy, providing potential benefits in targeted drug delivery, improved therapeutic efficacy, and reduced systemic toxicity. Aim: This narrative review examines progress in the creation and utilization of surface-modified NPs, emphasizing their function in traversing the blood-brain barrier and selectively targeting glioblastoma cells. Methods: This review consolidates findings from an extensive search of principal medical databases, highlighting in vitro, in vivo, and ex vivo investigations on surface-modified NPs in the treatment of GBM. The discourse emphasizes diverse methodologies, surface alteration procedures, and their ramifications for therapeutic effectiveness and clinical relevance. Results: In the last ten years, considerable advancements have been achieved in customizing NPs for targeting GBM. Surface modifications, including conjugation with ligands, peptides, or polymers, have significantly enhanced NP stability, biocompatibility, and specificity. Receptor-mediated targeting has been a primary method, utilizing unique molecular markers that are overexpressed on GBM cells to improve the precision of drug delivery. Dual-targeting strategies that focus on both the blood-brain barrier and tumor microenvironment have demonstrated promise in enhancing therapeutic results. Moreover, sophisticated surface characterization methods have yielded essential insights on NP efficacy, guaranteeing the dependability and consistency of these systems. Preclinical models, especially in vivo studies, have highlighted the translational potential of these methods, showing enhanced medication penetration and efficacy in difficult GBM scenarios. Conclusions: Surface-modified NPs signify a groundbreaking advancement in GBM therapy, providing novel answers to persistent difficulties. By combining innovative surface engineering with tailored therapeutic administration, they aim to improve treatment accuracy and reduce off-target consequences. Nevertheless, substantial obstacles persist, such as tackling NP toxicity, enhancing surface modification techniques, and guaranteeing scalability for clinical use
Parametric Study of Methanation Performance on Ru/Na2O/Al2O3 Dual-Function Materials
No full textThe development of Dual-Function Materials (DFMs) for the combined CO2 capture and valorization is gaining increasing attention due to its process intensification approach and promising advantages in terms of energy requirements. Significant efforts are devoted to optimizing materials and process configuration, but on both sides many issues still remain open. In this work the behavior of dry milled Ru/Na2O Dual-Function Materials on an alumina-based support with different methanation kinetics is evaluated for the coupled CO2 capture and hydrogenation to methane. In particular, the duration of the methanation step is changed to investigate its effect on the overall efficiency of the material, measured in terms of both CH4 yield and H2 conversion. The results show that, by opportunely tuning this parameter, it is possible to increase the average specific methane production rate by a factor of 1.9 or 2.6, the improvement being all the more significant the faster the CO2 methanation kinetics, increasing also the noble metal utilization efficiency
La poesia di Menzogna e sortilegio. Leopardi, Saba, Penna e l’antidoto alla tragedia
No full textSulle soglie, come la dedica Alla Favola e Ai personaggi, o entro il testo
nel commiato del Canto per il gatto Alvaro, la poesia di Menzogna e sortilegio (1948)
concorre alla complessa testualità del romanzo d’esordio di Elsa Morante. L’intervento
vuole leggere i versi della scrittrice nel dialogo intertestuale con Alibi (1958)
– lo studio filologico delle carte morantiane rivela infatti dei rapporti genetici di
rilievo con Menzogna e sortilegio – e in relazione alle istanze melodrammatiche del
romanzo assodate dalla critica, con la finalità di contribuire alla definizione della
testualità di Menzogna e sortilegio e della poetica di Morante, che con la poesia ha
sempre dichiarato un rapporto fondativo e passionale
High-fidelity human chromosome transfer and elimination
No full textThe synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) the facile transfer of human chromosomes from human cells to mouse embryonic stem cells (assembly cells), where they are haploid, are nonessential, and may be operated on; (ii) the transfer of these human chromosomes from monochromosomal hybrids back into human cells to generate defined, synthetic aneuploidies; and (iii) the elimination of the corresponding endogenous human chromosomes to regenerate diploid cells containing a transferred chromosome. All steps were performed in nontransformed cells without chromothripsis and generated minimal structural variants, insertions, deletions, or single-nucleotide variants
Audizione informale avanti la «Ia Commissione del Senato: “Affari costituzionali”», sul d.d.l. cost. a.C. n. 1917, dd.dd.ll. nn. 1353 e 504: «Norme in materia di ordinamento giurisdizionale e di istituzione della Corte disciplinare ». Con: dott. Gianrico Carofiglio (ex magistrato e già senatore nella XVI legislatura); Aldo Policastro (Procuratore generale di Napoli); Armando Spataro (ex magistrato e giurista, già Procuratore presso il Tribunale di Torino).
No full textNel corso dell'audizione informale tenuta il 4 marzo 2025 avanti la «Ia Commissione del Senato: “Affari costituzionali”», il prof. Mazzarolli esprime, su invito, la sua opinione sul d.d.l. cost. a.C. n. 1917, dd.dd.ll. nn. 1353 e 504, recante: «Norme in materia di ordinamento giurisdizionale e di istituzione della Corte disciplinare»
Repertorio della scrittura delle religiose nell'epoca della Controriforma
No full textPrésentation du Répertoire, réalisation finale du Prin 2022 Bringing Out an Invisible Female Literary Corpus: Religious Writing in the French-Speaking World at the Time of the Counter-Reformation. Census and Repertoire of a New Corpus. Towards a Reorganization of the Canon in a Gendered Perspective
Perspectives of Italian lay persons who would decline genetic risk information: “I think I'd be living in constant worry”
No full textThis study explores lay public perspectives on intrafamilial genetic risk communication, focusing on individuals who hypothetically choose not to receive genetic information, a largely overlooked population in genetic counseling research. A nested cross-sectional online survey combining both closed- and open-ended questions was used. Quantitative data included sociodemographic characteristics, family functioning as measured with the SCORE-15, genetic literacy (score range 0–4), and preferences regarding whether participants would want to be informed of a genetic risk in their family across three hypothetical scenarios (Cystic Fibrosis, Hereditary Breast and Ovarian Cancer and early-onset Alzheimer's disease). These data were analyzed using descriptive and inferential statistics. Qualitative data, consisting of open-ended responses on the reasons for not wanting to be informed, were analyzed inductively through reflexive thematic analysis. Of the 609 lay participants, 44 (7.2%) expressed a hypothetical preference not to be informed of a genetic risk in their family. Qualitative analysis of their responses revealed four main themes: (1) worry about anxiety and emotional distress in oneself and loved ones; (2) protection against psychological harm; (3) probability, uncertainty, and skepticism about preventive medicine; and (4) worry about stigma. These findings highlight the emotional, ethical, and social complexity behind the decision to decline genetic risk information and underscore the need for strategies to encourage and facilitate intrafamilial genetic risk communication that goes beyond education alone