Archivio della ricerca della Scuola Superiore Sant'Anna
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Stability in search of explanations: Quantifying Italian businesswomen in the twentieth century
No full textCollaborative Governance e Long-Term Care. Il caso dei servizi residenziali per non autosufficienti in Regione Toscana -Collaborative Governance and Long-Term Care. The case of residential services for dependent people in the Tuscany Region (Italy)
No full textI problemi di salute pubblica, come la non autosufficienza degli anziani, sono globali, interdipendenti, complessi e a volte imprevedibili. Sono definiti wicked problem poiché i soggetti coinvolti hanno interpretazioni e interessi contrastanti rispetto alla loro risoluzione, e possono essere affrontati attraverso approcci di collaborative governance. Infatti, i servizi sociosanitari sono caratterizzati da una elevata frammentazione istituzionale, dovuta al modello organizzativo, e dalla presenza di altri attori pubblici e da privati for profit e non. Questo articolo studia i servizi sanitari e sociosanitari per non autosufficienti, focalizzandosi sulla fase di quantificazione dei servizi residenziali, attraverso il caso della Regione Toscana nella programmazione di lungo periodo dei posti letto delle strutture residenziali.Public health problems, such as the non-self-sufficiency of the elderly, are global, interdependent, complex, and sometimes unpredictable. They are defined as wicked problems because the actors involved have conflicting interpretations and interests concerning their resolution, and can be addressed through collaborative governance approaches. Indeed, social and health services are characterized by a high degree of institutional fragmentation, due to the organizational model, and the involvement of various public, private, for-profit and non-profit entities. This article studies social and health services for the dependent elderly, focusing on the commissioning stage of the residential services, through the case of the Tuscany Region in the long-term planning of nursing home beds
AI Act Between Selectivity and Discrimination. The State of the Art of National and EU Regulation
No full textLow-frequency ultrasound triggers drug release from perfluorocarbon droplets at low intensities
Get PDFPerfluorocarbon droplets represent a promising platform for ultrasound-triggered drug delivery. Their liquid core can vaporize upon the application of a pressure wave such as ultrasound, resulting in the controlled and targeted release of their drug cargo. These carriers are highly tunable, exhibit a sharp on–off behavior and have longer lifetimes compared to ultrasound-responsive microbubbles. However, despite increasing efforts in the field, achieving an acceptable balance between stability and a safe activation threshold remains challenging. Indeed, stable droplet formulations are usually activated at very high ultrasound pressures, exceeding 1 MPa, raising safety concerns. In this study, we investigated the response of stable surfactant-shelled perfluoropentane droplets to low-intensity pulsed ultrasound. We demonstrated that a significant drug release can be triggered at a pressure as low as 100 kPa using a very low frequency (i.e., 38 kHz). Therefore, we focused on characterizing the behavior of this droplet formulation under 38 kHz ultrasound stimulation, optimizing a protocol able to achieve efficient drug release while adhering to safety guidelines, thus facilitating a future in vivo translation. We systematically examined how drug delivery efficiency varies with different stimulation parameters, including pressure, pulse repetition frequency and duty cycle. Additionally, high-speed camera imaging and ultrasound imaging were performed to further elucidate the response mechanisms of perfluorocarbon droplets to low-frequency ultrasound
Cardiac Biomarkers in Patients With Suspected Amyloid (Transthyretin) Cardiomyopathy: Which Cut-Offs?
Get PDFTrastuzumab cardiotoxicity and drug cardioprotection in healthy and cardiac dysfunction mouse models
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L’Italia e l’obbligo di cooperazione con la Corte penale internazionale: riflessioni attorno al caso Almasri
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