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The impact of environmental dynamism and board digital expertise on the method and scope of a firm's strategic change
No full textWe address the lack of understanding regarding the factors that drive strategic change (SC) in firms amidst unexpected and complex transformations. Our study examines both internal and external factors and dissects SC into its main strategic directions: method and scope. Drawing from resource dependence theory (RDT) and dynamic managerial capabilities (DMC), we argue that environmental dynamism and board digital expertise, as well as their interaction, play significant roles in the method and scope of SC. Our findings show that environmental dynamism and board digital expertise positively influence the method and scope of SC, but also that their interaction has a negative impact on these relationships. By integrating RDT and DMC, and by highlighting the determinants of SC, this study contributes to the advancement of scholarly understanding of SC and provides interesting insights for a wide audience of scholars, managers, and policymakers
Per uno studio dei casi di contatto linguistico tra varietà romanze medievali: i carteggi mercantili di Piero di Matteo Tecchini
No full textStudi dei Custodi Consapevoli della Legalità, vol. 4
No full textIn questo quarto volume della collana “Custodi Consapevoli della Legalità” si pubblicano sei capitoli, frutto di ricerche di laureate e laureati del nostro ateneo, incentrati sui temi della legalità. In particolare, si pubblicano qui contributi che rimandano a due diverse aree del progetto, il patrimonio sociale e culturale, anche se, per la loro natura interdisciplinare, intercettano e propongono temi e questioni relativi anche ad altre aree. In questo quarto volume si è tentato di valorizzare il talento di brillanti laureate e laureati che hanno meritato la pubblicazione del loro lavoro, evidenziando così l’importanza di rendere consapevoli le persone, a partire da loro stesse/i, dell’importanza di custodire e tutelare i patrimoni comuni attraverso lo strumento della legalità.In this fourth volume of the editorial series Custodi Consapevoli della Legalità, six chapters are published, the result of research carried out by graduates of our university and focused on issues of legality. In particular, this volume brings together contributions that relate to two different areas of the project, social and cultural heritage, although, due to their interdisciplinary nature, they also engage with themes and questions connected to other areas. This fourth volume seeks to highlight the talent of outstanding graduates whose work has deserved publication, thereby underscoring the importance of fostering awareness, beginning with these authors themselves, of the need to safeguard and protect shared forms of heritage through the tools offered by legality
I TRIBUTI STATALI. L'IMPOSTA SUL REDDITO DELLE PERSONE FISICHE. I CARATTERI GENERALI (PARTE I, CAPITOLO I), SEZ. 1
No full textPrincipi generali dell'Irpef ed analisi degli eelmenti base della fattispecie imponibile
Psilocybin improves novel object recognition in a rat model of Fragile X Syndrome through the modulation of the BDNF/TrkB signaling pathway
No full textFragile X Syndrome (FXS) is the most common inherited intellectual disability and a leading monogenic cause of autism spectrum disorder (ASD). As a synaptic disorder, FXS involves the loss of Fragile X messenger ribonucleoprotein 1 (FMRP), leading to abnormal dendrite development and immature dendritic spines. Serotonergic signaling, essential for neuronal development and circuit remodeling, has been implicated in ASD and related conditions, including FXS, raising the possibility that serotonergic modulation could ameliorate neurodevelopmental impairments. This study investigated the therapeutic potential of psilocybin, a serotonergic compound, in the validated Fmr1-Δexon 8 rat model of FXS. Psilocybin microdosing rescued deficits in NOR. Importantly, its benefits on recognition memory persisted despite pretreatment with the 5HT2AR antagonist, volinanserin, or the 5HT1AR antagonist, WAY-100635, indicating that classical serotonergic receptor activation is not required. In contrast, pretreatment with the TrkB receptor antagonist, ANA-12, abolished psilocybin’s effects, implicating BDNF/TrkB signaling as essential. At the molecular level, psilocybin normalized mature BDNF (mBDNF), increased TrkB, and restored downstream AKT signaling in the prefrontal cortex of Fmr1-Δexon 8 rats, pathways strongly linked to synaptic plasticity and cognitive function. These findings demonstrate that psilocybin rescues object recognition memory deficits in this rat model of FXS via BDNF/TrkB-AKT signaling rather than serotonergic receptor mechanisms. By dissociating therapeutic effects from hallucinogenic pathways, our results highlight psilocybin microdosing as a promising therapeutic strategy for neurodevelopmental disorders such as FXS and ASD
Sperm morphology and ultrastructure in four species of ground beetles (Insects-Carabidae)
No full textGround beetles (Carabidae) exhibit diverse sperm morphologies, ranging from free cells to conjugated bundles
embedded in spermatostyles. Detailed ultrastructural analyses of four species - Paussus favieri (Paussinae), Tachys
scutellaris and Pogonus littoralis (Trechinae), and Laemostenus acutangulus (Harpalinae) - were conducted using
transmission electron and fluorescence microscopy. Free sperm were observed in P. favieri, T. scutellaris, and
P. littoralis, with notable features including a monostratified acrosome and polysaccharide-rich granular material
in P. favieri, and unique accessory bodies in T. scutellaris. L. acutangulus displayed sperm conjugated within
crystallized spermatostyles, suggesting the presence of enzymatic proteins. These findings reveal structural diversity
linked to phylogenetic positions, suggesting that free sperm predominate in basal lineages, while conjugated
sperm with spermatostyles are characteristic of higher Carabidae. The study enhances understanding of
sperm evolution and reproductive adaptations in ground beetles, providing a foundation for future comparative
and systematic investigations. As a final consideration, it was hypothesized that sperm conjugation could be the
ancestral condition of insect reproduction
