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Interpretative Streams to Foster the Operational Nexus between the Women, Peace and Security Agenda at 25 and the Beijing Declaration and the Platform for Action at 30 within the UN System
No full textAs the international community marks the 25th anniversary of the Women, Peace and
Security (WPS) Agenda and the 30th anniversary of the Beijing Declaration and Platform
for Action (BPfA) in 2025, renewed attention is needed to foster operational synergies
between these two landmark gender equality frameworks within the United Nations system.
This contribution explores a series of interpretative streams designed to bridge the
normative, institutional, and programmatic gaps that have historically separated the
WPS and BPfA agendas. Drawing on legal instruments, UN policy processes, and feminist
critique, it outlines several strategic streams: (1) A human rights-centric approach
anchored in the UN Convention on the Elimination of Discrimination Against Women
(CEDAW); (2) Institutional mainstreaming to align implementation across UN statutory
key pillars; (3) Formal and substantive innovations as a lens to address structural gender
inequalities; (4) Transformative participation to elevate women’s political agency in the
UN annual agenda on peace and security issues; (5) A new vision to reshape the UN and
its membership commitment for the revitalization of the Commission on the Status of
Women (CSW). By situating these approaches in the follow-up to CSW69 and Beijing+
30, as well as in the lead-up of the 25th anniversary of the WPS Agenda, the contribution
proposes a roadmap for advancing coherent, inclusive, and transformative gender-
responsive peace and development tracks in the multilateral system
Il ruolo del razzismo nella scuola coloniale italiana in eritrea: conoscenze, potere e controllo
No full textLo studio propone una riflessione critica sul ruolo dell’istruzione nella costruzione legittimazione delle disuguaglianze in epoca coloniale. Il contributo esplora in che modo il razzismo abbia costituito un elemento strutturale e pervasivo del sistema educativo coloniale italiano in Eritrea. Attraverso l’analisi di documenti inediti conservati presso l’Archivio Storico Diplomatico del Ministero degli Affari Esteri, unitamente allo studio delle politiche scolastiche, dei manuali didattici e delle pratiche educative adottate, si evidenzia come l’istruzione fosse volontariamente funzionale al mantenimento del dominio coloniale. L’immagine degli autoctoni come esseri inferiori, privi di capacità autonome di apprendimento, veniva usata dal governo italiano per giustificare l’offerta di un’educazione limitata e subordinata, volta a formare sudditi docili piuttosto che cittadini consapevoli. In questo contesto, la scuola diventava uno strumento chiave per consolidare la logica dei dominatori, contribuendo alla riproduzione delle gerarchie sociali e culturali imposte dal potere coloniale.This paper offers a critical reflection on the role of education in the construction and legitimation of inequalities during the colonial period. The study investigates how racism was constituted as a structural and pervasive component of the Italian colonial education system in Eritrea. Through the analysis of previously unpublished documents held at the Historical Diplomatic Archive of the Italian Ministry of Foreign Affairs, alongside the study of educational policies, textbooks, and pedagogical practices, the research highlights how schools were intentionally used to serve the maintenance of colonial rule. The portrayal of the local population as inferior beings, allegedly incapable of autonomous learning, was used by the Italian government to justify a limited and subordinate form of education, aimed at producing obedient subjects rather than conscious citizens. In this context, schools became a key instrument for consolidating the logic of the colonizers, contributing to the reproduction of the social and cultural hierarchies imposed by colonial power
The integrable Volterra system in the case of infinitely manyspecies, either countable or uncountable
No full textIn the present paper we derive a further extension of the results contained in two recent articles, both published in Open Communications in Mathematical Physics, where it was shown that the integrable version of the N-species Volterra model, introduced by V. Volterra in 1937, is in fact maximally superintegrable. Here we point out that the superintegrability property applies as well to the case of infinitely many competing species, either countable or uncountable. Analytical and numerical results are given
CAPITALI, INVESTIMENTI E RISPARMIO: IL CONTESTO EUROPEO
No full textSOMMARIO: 1. Capitali, investimenti e risparmio: il contesto europeo. — 1.1. Funzionalismo d’origine, federalismo per vocazione. — 1.2. Il compromesso di Lisbona e il nuovo approccio alle crisi. — 1.3. Obiettivo federalista, metodo funzionalista. — 1.4. Il triangolo del commercio. — 2. La Saving Investment Union come componente della sovranità. — 2.1. Il convidado de piedra. — 2.2. Centralizzazione e flessibilità. — 2.3. Priorità regolatorie e spirito del tempo. — 2.4. La risposta: il circolo regolatorio. — 2.5. Saving Investment Union tra pubblico e privato... — 2.6. ... e tra gold plating e semplificazione.
— 3. Normazione per principi
Integrin αvβ3-dependent pathogenic effect and therapeutic effects of DL-N2 combined with EGFR inhibitors in pancreatic adenocarcinoma
No full textBackground
Pancreatic adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by aggressive progression, pronounced stromal desmoplasia, and a limited response to targeted therapies. Although epidermal growth factor receptor (EGFR) inhibitors have shown promise in preclinical studies, their clinical efficacy has been modest, suggesting the existence of compensatory signaling networks.
Methods
An integrated analytical framework was employed, combining bulk transcriptomic analyses of TCGA-PDAC and GTEx datasets, DNA methylation profiling, protein–protein interaction (PPI) network analysis, immune infiltration estimation, and single-cell RNA sequencing. Expression patterns and clinical associations of integrin αvβ3 were evaluated using TCGA, GEPIA, UALCAN, and the Human Protein Atlas. Functional validation was performed using in vitro assays in pancreatic cancer cell lines to assess the effects of DL-N2, a tetrac-conjugated nanoparticle targeting integrin αvβ3, alone or in combination with gefitinib.
Results
Integrin αvβ3 (ITGAV/ITGB3) was upregulated in PDAC tissues compared with normal pancreatic tissue and was associated with poor prognosis. Single-cell transcriptomic profiling localized αvβ3 expression to malignant ductal cells and stromal fibroblasts. Computational analyses predicted strong associations of αvβ3 with EGFR, MMP2, and MMP9, implicating it in epithelial–mesenchymal transition (EMT), extracellular matrix (ECM) remodeling, and immune regulation. In vitro, experiments showed that DL-N2 suppressed basal and EGF-induced proliferation, decreased the expression of EGFR, PCNA, and CCND1, and reduced angiogenic and invasive mediators, including VEGF-α, bFGF2, and MMP9. Notably, DL-N2 inhibited PD-L1 expression, linking αvβ3 signaling to immune evasion. In addition, both DL-N2 and gefitinib inhibited cell migration, and their combined treatment exerted an additive effect on the suppression of pancreatic cancer cell migration.
Conclusion
Our findings establish integrin αvβ3 as a multifunctional regulator of pancreatic cancer progression, integrating growth-associated signaling, extracellular matrix regulation, and immune-associated pathways. Targeting αvβ3 with DL-N2 remodels both tumor-intrinsic and microenvironmental pathways, potentially enhancing EGFR inhibition and restoring chemosensitivity. Dual blockade of αvβ3 and EGFR represents a rational therapeutic strategy to overcome drug resistance and improve outcomes in PDAC
Micromammal-based paleoprecipitation estimates for the late Middle and early Late Miocene record of the Vallès-Penedès Basin (Catalonia): Implications for primate habitats
No full textMulti-site seismocardiographic measurements for the estimation of cardiac output in patients with aortic stenosis
No full textCardiac Output (CO) measurement is critical for assessing cardiovascular efficiency, particularly in patients with aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). Traditional CO monitoring techniques, including invasive and non-invasive methods, often provide only intermittent measurements, limiting their ability to track rapid hemodynamic changes. This study presents a novel approach using wearable wireless inertial measurement units (IMUs) to continuously measure CO through electrocardiogram (ECG) and seismocardiogram (SCG) signals. Our method leverages seismocardiographic techniques combined with machine learning algorithms to provide real-time insights into hemodynamic status. Clinical trials involving 11 patients demonstrated the feasibility and accuracy of this approach, with data collected on the patient's chest from multiple auscultation areas, including the aortic, mitral, pulmonary, and tricuspid valves, as well as the xiphoid process. To assess whether the choice of valve position or measurement axis significantly affected the accuracy of CO estimations, a Kruskal–Wallis non-parametric analysis of variance (ANOVA) for each performance metric was performed. This test was chosen due to the small sample size and the lack of normality in the data distributions. The analysis did not reveal any statistically significant difference. This study validates the proposed method's accuracy against the indirect Fick method and investigates different measurement sites. Our findings suggest that continuous, non-invasive CO monitoring using SCG and ECG signals could enhance clinical decision-making during TAVI and potentially other surgical procedures, offering a practical and portable alternative to traditional invasive monitoring systems
