37333 research outputs found
Sort by
Shock-Fitted Calculation of Steady Mach Reflections in Overexpanded Nozzles Using Structured Grids
No full textWhen nozzles operate in overexpanded regime, as during engine startup and shutdown of space launchers, flow separations in the divergent section may occur and cause large lateral forces. More in general, flow separation is characterized by an oblique shock, necessary to permit the supersonic flow to deviate and to adapt to the ambient conditions. The separation shock always reflects on the nozzle axis by a Mach reflection, whose features depend on the upstream flow conditions, usually not uniform. In this paper the details of the shock structure and flowfield obtained in an overexpanded parabolic nozzle are analyzed using a novel shock-fitting technique
Il “massacro della Carnale” nella cronaca dello pseudo Nicolò de Iamsilla
No full textIl saggio analizza la distruzione di Ariano (1255) nella Historia dello pseudo Iamsilla, collocandola nel contesto della riconquista del Regno da parte di Manfredi dopo la morte di Federico II e Corrado IV. La città, roccaforte filopapale ritenuta inespugnabile, fu presa con un inganno orchestrato da Federico Maletta e devastata con un massacro notturno. L’articolo evidenzia la strategia narrativa filomanfrediana della fonte, che tende a sollevare il sovrano dalle responsabilità dirette, e sottolinea la necessità di un uso critico del testo, anche alla luce delle accuse papali e dei problemi della tradizione manoscritta
Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery
No full textThis study delves into the impact of two synthetic non-natural amino acids, 7 and 8, on the structural dynamics of serum albumin and their potential significance in anticancer drug delivery systems. Crucially, the dihydrofuran-containing compound 7 has been identified to bind to the G-quadruplex (G4) DNA sequence 22-mer Pu22, a mimic of the proto-oncogene c-Myc, as ascertained by circular dichroism (CD) and UV spectroscopy. Our docking studies suggest that 7 binds to the G4 structure from the side of the G-quartet in a quasi-parallel manner, engaging in ten intermolecular interactions, including hydrogen bonds, π-lone pair and π-alkyl interactions. Notably, one interaction involves the heterocyclic ring of the compound. Compound 7 emerges as a notable structure modulator, showcasing a significant enhancement in protein α helix formation, as observed in a serum albumin binding CD experiment, and the capability to form supramolecular networks, as evidenced by dynamic light scattering (DLS) and Scanning Electron Microscopy (SEM), with the added benefit of encapsulating the natural anticancer drug curcumin within its self-assemblies. Toxicity assessments on human fibroblast cell lines demonstrate that both compounds are non-toxic, highlighting their biocompatibility and potential for safe biomedical applications. Interestingly, the triazole-based compound 8 induces distinctive structural changes in serum albumins, elucidated through CD and UV spectra using bovine serum albumin (BSA) as a model albumin target
Luspatercept treatment affects immune-regulatory subsets in patients with MDS with ring sideroblasts
No full textMyelodysplastic syndromes (MDSs) represent hematological disorders characterized by ineffective
hematopoiesis and increased risk of acute myeloid leukemia (AML)
On the potential of Advanced Microwave Sounding Unit (AMSU) data for assessing soil moisture variability in the Basilicata Region
No full textSoil moisture (SM) data can be used in various contexts related to the hydrological
cycle, including agricultural monitoring, water resource management, and natural
hazard assessment. In recent years, remote sensing data have been widely used
to retrieve SM data at different spatial and temporal scales. In this study, we
investigated the potential of the Soil Wetness Index (SWI), an index based on
data acquired by the Advanced Microwave Sounding Unit (AMSU) onboard the
Meteorological Operational Satellite Program of Europe (MetOp) satellites, to
provide reliable information on SM variability over a medium period. SWI variability
at the monthly scale in the 2013-2016 period was analyzed for the Basilicata region
(southern Italy), and the results, whose accuracy was evaluated for comparison
with the SM product generated using the Advanced SCAtterometer (ASCAT) data,
seem to indicate the good sensitivity of the proposed index, which showed mean
correlation (r) values around 0,73 when considering both MetOp-A and -B satellite
Interdisciplinary Method to Analyze Historical Water Resource Management Systems: The Case Study of Masseria del Cristo in Matera, Italy
No full textThe rural architecture of Matera preserves important traces of the historical heritage represented by integrated water resources management systems, which contributed to the inscription of the city on the United Nations Educational, Scientific and Cultural Organization (UNESCO)World Heritage List in 1993. The need to guarantee water supply led to theoretical and practical knowledge aimed at sustainable management of resources, both within the urban fabric of the Sassi and along the historical routes of transhumance. The farmhouse known as Masseria del Cristo, in the countryside of Matera, bears historical evidence of this heritage, unlike what is observable in urban areas due to the significant transformations undergone in recent decades. Excavated cisterns, settling tanks, dug channels and a semi-excavated cistern with a roof were detected through photogrammetric processes and represented through 3D digital models that are freely consultable online. Through the analysis of this specific case study, the contribution proposes an interdisciplinary multiscale method to investigate the relationship between historical water systems and the geomorphological and hydrological context in which said systems are located. The results of this process provide a solid starting point to guide proper practices for the protection, recovery and enhancement of this historical heritage
Measurement of WWZ and ZH Production Cross Sections at sqrt(s)=13 and 13.6 TeV
No full textA measurement is presented of the cross section in proton-proton collisions for the production of two W bosons and one Z boson. It is based on data recorded by the CMS experiment at the CERN LHC at center-of-mass energies sqrt(s)=13 and 13.6 TeV, corresponding to an integrated luminosity of 200 fb-1. Events with four charged leptons (electrons or muons) in the final state are selected. Both nonresonant WWZ production and ZH production, with the Higgs boson decaying into two W bosons, are reported. For the first time, the two processes are measured separately in a simultaneous fit. Combining the two modes, signal strengths relative to the standard model (SM) predictions of 0.75-0.29+0.34 and 1.74-0.60+0.71 are measured for sqrt(s)=13 and 13.6 TeV, respectively. The observed (expected) significance for the triboson signal is 3.8 (2.5) standard deviations for sqrt(s)=13.6 TeV, thus providing the first evidence for triboson production at this center-of-mass energy. Combining the two modes and the two center-of-mass energies, the inclusive signal strength relative to the SM prediction is measured to be 1.03-0.28+0.31, with an observed (expected) significance of 4.5 (5.0) standard deviations
Integrated reporting and SDGs in the public sector: Insights from a small Italian municipality
No full textThis study explores the implementation of the integrated reporting (IR) framework in a small Italian coastal municipality, analyzing the challenges and opportunities encountered during the process. Designed to provide a comprehensive view of value creation in the short, medium, and long term, the IR framework serves as a strategic tool for integrating financial and non-financial indicators, thereby contributing to the alignment of municipal policies with the Sustainable Development Goals (SDGs). The study also highlights how the IR framework can address the separation of ownership and control in the public sector by increasing transparency and accountability in the management of public resources. The study adopts a qualitative, multi-method approach, combining multiple data sources: 1) document analysis of municipal resolutions, deliberations, and strategic plans; 2) semistructured interviews with various stakeholders; and 3) participant observation during working sessions and stakeholder meetings. Data analysis was conducted using a triangulation approach, crossreferencing
different sources to enhance the validity and reliability of the findings. The research highlights an initial lack of awareness of IR and the SDGs, underscoring the need for training. It also reveals a stronger understanding of financial and manufactured
capital compared to intangible capital, alongside a limited perception of the municipality’s role in managing natural capital. IR emerges as a valuable tool for engaging employees and stakeholders in defining key parameters for evaluating outcomes in relation to the SDGs. Unlike previous studies focused primarily
on the private sector, this research demonstrates that the IR framework can be effectively adapted to the public sector, providing a holistic view of value creation that goes beyond
financial performance to include social and environmental impacts. Although limited to a single case, this study provides insights into the feasibility of IR in the municipal context, emphasizing the critical role of training and stakeholder engagement in fostering public value (PV) creation aligned with the SDGs
Albania-Basilicata: dinamiche migratorie in evoluzione
No full textOggi, la popolazione albanese, da lungo tempo legata al territorio lucano, è al centro di nuove dinamiche migratorie generate da prospettive d’impiego, anche nel settore agricolo del Metapontino. In Basilicata sono evidenti le criticità derivanti da spopolamento, invecchiamento e assenza di servizi, come mostra la perimetrazione individuata dalla Strategia Nazionale per le Aree Interne. A scala locale, tuttavia, emer-gono realtà potenzialmente attrattive per l’immigrazione internazionale. Nella prima parte del contributo si analizzano la struttura demografica albanese e i flussi migratori verso l’Italia; successivamente si considera l’andamento della popolazione in Basilicata, proponendo il caso di studio di Rotondella, nell’area del Materano. Qui si osservano forme di interazione e radicamento dei migranti nel tessuto locale, rilevando quanto l’immigrazione possa incidere sulla qualità della vita della comunità, ad esempio attra-verso il mantenimento dei servizi di base. Analisi quali-quantitative intendono indaga-re come tali aree marginali, interessate da costanti movimenti migratori, possano far fronte agli effetti della flessione demografica, dando impulso, al contempo, a processi di rivitalizzazione territoriale
