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Evaluation of Antibody–Drug Conjugate Performances Using a Novel HPLC–DAD Method for Tumor-Specific Detection of DM4 and S-Methyl-DM4
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Comprehensive Study of Habitat Substrate-Related Variability of Cotinus coggygria Scop. as a Valuable Source of Natural Bioactive Compounds
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Exploitation of lactic acid bacteria for the production of a fermented legume-based beverage
No full text70th Congress of the Italian Embryological Group-Italian Society of Development and Cell Biology (GEI-SIBSC)
No full textProceedings of the 70th Congress of the Italian Embryological Group-Italian Society of Development and Cell Biology (GEI-SIBSC) - Modena, 10-13 June 202
Miniaturization in action: High-resolution, low-cost analytical platforms for biomedical and pharmaceutical research
No full textGrowing concerns over environmental pollution have led to increased emphasis on Green Chemistry and, more specifically, Green Analytical Chemistry (GAC). These frameworks advocate for the reduction of hazardous substances, minimization of waste, and consideration of the entire life cycle of analytical procedures—from production to disposal. Within this context, miniaturized analytical techniques have emerged as sustainable and efficient alternatives to conventional methods. Among these, capillary liquid chromatography (cLC), nano-liquid chromatography (nano-LC), and various modes of capillary electrophoresis (CE)—including micellar electrokinetic chromatography (MEKC), capillary isotachophoresis (CITP), capillary zone electrophoresis (CZE), capillary isoelectric focusing (CIEF), and capillary gel electrophoresis (CGE) have gained significant traction. Their advantages in terms of reduced solvent and sample consumption, enhanced resolution, and faster analysis times have made them particularly valuable in pharmaceutical and biomedical applications. One critical application area is the chiral separation of active pharmaceutical ingredients (APIs), which is increasingly vital in biotechnology, chemistry, agriculture, and especially the pharmaceutical industry. Electrokinetic chromatography (EKC) has proven to be an effective and versatile technique for this purpose, offering high resolution, flexibility, speed, and cost-efficiency. The growing availability of novel chiral selectors further enhances its appeal for the separation of enantiomeric drug compounds. This review provides an overview of recent advancements in miniaturized analytical techniques and highlights their applications in the biomedical and pharmaceutical sectors, with a particular focus on chiral separations using EKC
Geochemical and microbial factors driving crustacean assemblages in adjacent aquifer units within the same aquifer
No full textThe impacts of seasonal weather anomalies on Italian farms’ total factor productivity
No full textUnderstanding how seasonal weather anomalies brought by climate change impact on agricultural productivity is fundamental to food security. To allow proper site- and season-specific policy responses, micro-level assessments are needed. This study uses a panel data econometric approach to assess the impact of weather anomalies on Italian farms’ total factor productivity (TFP) over the period 2008–2020 using micro-level data. Estimates point to a complex TFP–weather relationship. Results confirm that seasonal weather anomalies have a negative effect on agricultural performance of different farm typologies. Effects tend to be larger the larger the weather anomalies
Autonomia differenziata, acqua pubblica e sistema idrico integrato
No full textIl contributo si propone di offrire un'analisi critica delle richieste di autonomia differenziata avanzata da alcune regioni in materia di patriminio idrico nazionale e di gestione del servizio idrico. Le richieste di oggi, in contrasto con i principi della coesione sociale e territoriale, affondano le loro radici nell'instabile riparto territoriale tra Stato e regioni definito dall'art. 117 Cost. e confermato, nel caso di specie, dalla giurisprudenza costituzionale