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Investigating SMYD3 role during oocyte maturation in a 3D follicle-enclosed oocyte in vitro model in sheep
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Navigating Food Transition: European Policy Tools for Novel Foods and the Italian Debate on Cultured Meat
No full textThe global food system—encompassing production, consumption, and disposal—has been widely recognized as unsustainable, contributing significantly to environmental degradation and social disparities. In response to these challenges, the transition toward more equitable food systems has become imperative. Despite the widely acknowledged need to change Western eating habits, the transition toward more sustainable diets appears as a “false wicked problem” being characterized by intricate trade-offs between economic, ethical, societal, and environmental issues. This paper examines the crucial role of policy interventions in steering the shift and in considering the role that the emergence of novel foods and alternative proteins – such as cultured meat – might play within it. By employing a qualitative methodology, the study maps the policies governing novel foods in Europe, with a specific emphasis on the three tools of regulations, informational campaigns, and incentives. This paper gives particular attention to the cultured meat debate in Italy as a case study for approaching not only the multifaceted nature of food—an interplay of cultural values, economic interests, and political decision-making—but also the staunch resistance that such transition is likely to encounter. The main highlights underscore the need for a comprehensive and balanced approach to integrate regulatory measures, consumer education, and inclusive stakeholder engagement while stressing the importance of evidence-based choices, transparent communication, and the recognition of the socio-cultural dimensions in shaping food policies
Percorsi di decarbonizzazione e sistemi di controllo: un modello di analisi per il settore energetico
No full textIn response to global regulatory developments addressing carbon-related challenges, companies face an increasing pressure to adopt targeted emission reduction actions and enhance their performance in managing carbon emissions. To ensure a swift, effective, and lasting corporate response to systemic environmental challenges, it is essential to examine and understand how companies implement carbon reduction strategies and monitor their progress. This article employs a content analysis approach to highlight the greenhouse gas (GHG) management strategies and systems adopted by Italian listed companies operating in the energy sector. By analysing sustainability reports, this article delivers valuable insights for both scholars and practitioners, into how corporate planning and control practices for pursing carbon goals are integrated into disclosure process. Academically, we provide a framework for mapping corporate strategies and control systems aimed at managing carbon emissions. Practically, we identify best practices and offer guidelines to support planning and implementation of decarbonization strategies, adopt control mechanisms and tools, and develop internal and external engagement activities
Elena di Troia: seduzione, inganno, conflitto, colpa. Una lettura simbolico politica
No full textAttraverso la narrazione di alcuni emblematici personaggi femminili, gli autori dell’antichità definivano ruoli, identità, categorie di pensiero e di azione, ancora oggi presenti ed operanti nella nostra cultura occidentale. Elena di Troia, innalzata dai Greci ad ideale di Bellezza, una polis come Sparta, che per lei affrontò guerre e distruzioni, e una città come Troia che a causa sua fu assediata, ingannata e distrutta, pur attraverso le molteplici interpretazioni, spingono a chiederci come mai questo mito continui ad avere una così grande importanza nella cultura occidentale, e nell'analisi della dimensione simbolico-politica della differenza di genere
Intorno alla genesi della bolla Ite vos (1517) di Leone X: i negoziati diplomatici e la divisione dell’Ordine dei Minori
No full textDeepening Cisplatin sensitivity on Oral Squamous cell Carcinoma cell lines after PON2 knockdown: A FTIRM investigation
No full textCisplatin is a platinum-based chemotherapy drug with antimicrobial and antitumoral activity, largely used for a long time in the treatment of several cancers, including the Oral Squamous Cell Carcinoma (OSCC), which is one of the most frequent neoplasms of the oral cavity. Due to its aggressiveness and metastatic invasion, OSCC is characterized by poor outcome, often related also to chemoresistance mechanisms. The intracellular enzyme paraoxonase-2 (PON2) normally acts defending cells from the damages induced by Reactive Oxygen Species. Hence, in cancer cells, this enzyme can shield the potential of cisplatin, triggering a resistance mechanism. Based on this evidence, PON2 knockdown seems to be a valuable way to enhance the effects of chemotherapy, escaping this resistance. In this study, HOC621 and HSC-3 OSCC cell lines submitted to PON2 silencing were analyzed by Fourier Transform Infrared Microspectroscopy to evaluate the time-dependent changes occurring in these cells after cisplatin treatment. Spectral data were statistically analyzed by multivariate and univariate analyses and compared with MTT results. Positive feedback on cisplatin efficacy was found in both cell lines submitted to PON2 knockdown, even if with a different response. In particular, a less growth was found in PON2 silenced HOC 621 cells, respect to HSC-3 ones. Moreover, specific spectral markers (A1172/ATOT, A1053/ATOT, A967/A1080, and A992/ATOT band area ratios) were identified and statistically analyzed (p < 0.05): cellular alterations mainly in nucleic acids and carbohydrates were found in both cell lines, although more evident in HOC 621 ones, which therefore appeared to be more affected by chemotherapy treatment