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Adaptive strategies of Listeria monocytogenes: An in-depth analysis of the virulent strain involved in an outbreak in Italy through quantitative proteomics
No full textDespite the general classification of L. monocytogenes strains as equally virulent by global safety authorities,
molecular epidemiology reveals diverse subtypes in food, processing environments, and clinical cases. This study
focuses on a highly virulent strain associated with a listeriosis outbreak in Italy in 2022, providing insights
through comprehensive foodomics approaches, with a specific emphasis on quantitative proteomics. In particular,
the ST155 strain of L. monocytogenes strain was subjected in vitro to growth stress conditions (NaCl 2.4 %, pH 6.2,
T 12 ◦C), mimicking the conditions present in the frankfurter, its original source. Then, the protein expression
patterns were compared with those obtained in optimal growth conditions.
Through quantitative proteomic analysis and bioinformatic assessment, different proteins associated with
virulence during the exponential growth phase were identified. This study unveils unique proteins specific to
each environment, providing insights into how L. monocytogenes adapts to conditions that are similar to those
encountered in frankfurters. This investigation contributes valuable insights into the adaptive strategies of L.
monocytogenes under stressful conditions, with implications for enhancing food safety practices
Characterization of biochemical traits, volatile compounds, and sensorial attributes of pistachio (Pistacia vera L.) nuts and oil as affected by regulated deficit irrigation and roasting
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Amniotic epithelial Cell microvesicles uptake inhibits PBMCs and Jurkat cells activation by inducing mitochondria-dependent apoptosis
No full textNeural Markers Predict Tendon Healing Outcomes in an Ovine Achilles Tendon Injury Model: Spontaneous Repair Versus Amniotic Epithelial Cell-Induced Regeneration
No full textTendon injuries pose a clinical challenge due to tendons' limited recovery. Emerging evidence points to the nervous system's critical role in tendon healing, with neural markers NGF, NF-200, NPY, CGRP, and GAL modulating inflammation, cell proliferation, and extracellular matrix (ECM) remodeling. This study investigates the predictive role of selected neural markers in a validated ovine Achilles tendon injury model, comparing spatio-temporal expression patterns in regenerating tendons transplanted with amniotic epithelial stem cells (AECs) versus spontaneous healing (CTR) 14 and 28 days post-injury (p.i.). AEC-treated tissues showed a spatio-temporal modulation of NF-200, NGF, NPY, CGRP, GAL, and enhanced ECM remodeling, with greater cell alignment, lower angle deviation, and accelerated collagen maturation, with a favorable Collagen type 1 (COL1) to Collagen type 3 (COL3) ratio. Pearson's matrix analysis revealed significant positive correlations between NGF, CGRP, and GAL expression, along a positive correlation between the three neural markers and cell alignment and angle deviation. As opposed to CTR, in AEC-treated tendons, lower levels of NGF, CGRP, and GAL correlated positively with improved tissue organization, suggesting these markers may predict successful tendon regeneration. The findings highlight the neuro-mediated activity of AECs in tendon regeneration, with NGF, CGRP, and GAL emerging as key predictive biomarkers for tendon healing
Michelangelo Unveiled. Bussotti’s «Nottetempo»
No full textA particularly representative example of the frequent thematisation of all-round eroticism in Bussotti’s operas is Nottetempo, “a one-fragment lyrical drama based on Varagine, Michelangelo and Sophocles”. Commissioned by the Teatro alla Sca- la, the opera debuted at the Teatro Lirico in Milan on 7 April 1976 in a diptych with Oggetto amato, marking the birth of BussottiOperaBallet.
The chapter investigates how queerness permeates this original reinterpretation of a classical myth. Elements of the plot and the scenography designed by Bussotti for the premiere are explained in terms of the author’s wish to underscore the homoerotic desire.
The aria sung by the protagonist in the section Nottetempo – the third of the four parts into which the work is divided – is read in light of Bussotti’s intent to underscore the erotic charge of the passage. Quotations from Michelangelo’s Rime, from Heimito von Doderer’s «The Lighted Windows» and from a story by Aldo Palazzeschi are also read in this context.
Lastly, some excerpts from the press review of the première are discussed to highlight how most journalists harshly criticised the opera because of its contro- versial topic
No Word for Worry. Sacred and Environmental Concerns in the Social Transition between Sea and Land of the Moken and Urak Lawoi of Thailand
No full textIn the documentary on the life of the Moken people, sea nomads
of Thailand (Wiik 2014), the protagonist of the film states that in
the Moken vocabulary there are no words that describe the feeling
of worry about the future: “No word for Worry” (which is also the
title of the documentary). Living in a symbiotic relationship with
the ocean, a true total social fact (Mauss 1925), tomorrow is not
a concern as it depends on a larger and uncontrollable dimension
capable of ordering life and giving it meaning. In this regard, it is
worth noting how Luhmann (1993) mentioned that ancient people
had more tools than us to protect themselves from misfortunes. We
moderns are exposed to chance and aware of it, but at the same time
overwhelmed by the weight of responsibility for choices regarding
an uncertain future that nevertheless depends on us. As a matter of
fact, the future of modernity is contingent, not accidental (Aristotle)
compared to a necessary reality, because it is given as creatum,
already existing. For Luhmann, the result is the modern splitting
of the future, indicating a tension between society and time, where
society self-describes as future, with no observable present, inher-
ently elusive, and the past no longer existing. This transposition
of society into the future coincides with the decline of the sacred
(Durkheim 1912; Douglas 1966, 1992) and the weakening of
social bonds in favour of the society of the individual. Indeed, the
profane dimension of global society is continuous and is produced
through a spatial-temporal dis-embedding that lacks festive suspen-
sion and regenerative expenditure as even the celebration becomes
an individual choice, hyper-cultural (Han 1923) and commercial.
Accordingly, this contribution addresses the relationship between the
temporal dimension, the sacred, and ecological concerns within the
specific context of the social transition from maritime nomadic life to
sedentary terrestrial life among the sea nomads of Thailand (Moken
and Urak Lawoi). It discusses the importance of the risk-oriented
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description of the future in the contemporary society, as opposed to
the way sea nomads express environmental concerns, to conclude
with a reflection on the perspective of a sacred ecology to reconnect
social relations with the environment in present day society. As a
matter of fact, in present time we are no longer facing the ontology
of the Lascaux caves (Bataille 1955): a powerful reality that mani-
fests as artistic-religious experience, capturing the fleeting nature of
becoming in the hic et nunc, in the “aura” (Benjamin 1935). We no
longer deal with a strong ontology, with a presence of being capable
of leading to the belief, as with the Moken and the Urak Lawoi, that
there are no words to express concern about the future. However,
even in the modern era, the sacred sets but does not disappear. The
dimension of the sacred remains as an ineffable latency that accom-
panies, like an unexpressed double, the grotesque (phantasmatic)
description of the future social. Its manifestations are different from
those of ancient communal communities, falling within the realm
of individual action, individual attribution and search for meaning,
risk-taking. Simultaneously, the sacred dimension revitalizes social
bonds, and forms of communal experience, linked to the sea, persist
and shape the social life of populations such as the Moken and the
Urak Lawoi, who experience the risk of losing that deep connec-
tion under the pressures of modern life. As a result, they lack words
for worry, but also a risk semantics. Therefore, the condition of the
Moken, exposed to the risks of climate change, over-tourism, natural
disasters (Tsunamis), security segregation, and intensive fishing,
suggests a critical reflection on the relationship between fear and
social innovations in relation to environmental concerns viewed
through the lens of sacred ecology
Introduzione. Forme di comunicazione pubblicitaria tra social media e Intelligenza Artificiale
No full textThe advertising text has often been the subject of semiotic studies. From its earliest analyses in the 1960s to its most recent applications, semiotics has always found advertising an extremely propitious opportunity to test its tools, in an attempt to identify its specificity in relation to the other human and social sciences. The mutability of advertising discursive forms has been a challenge for semiotics, opening reflections and prompting debates on the potentiality, limits and relevance of semiotic analytical tools. This aspect appears particularly interesting within the dynamics of the contemporary communicative context, characterized by the advent of social advertising, the contamination between different media, the entry of new technologies and the spread of Artif icial Intelligence in consumer practices, fruition and production of advertising text