University of Naples Federico II
Archivio della ricerca - Università degli studi di Napoli Federico IINot a member yet
367950 research outputs found
Sort by
CHEX-MATE: Relationship between X-ray and millimetre inferences of galaxy cluster temperature profiles
No full textChemical investigation of secondary metabolites from marine-derived fungus Clonostachys rosea with antiviral and antimicrobial potential
No full textThe oceans represent a still largely unexplored environment for the discovery of new bioactive molecules. Due to their biodiversity and extreme environmental conditions, they have provided a basis for the development of a wide range of compounds with significant biological activities. Many bioactive molecules have been discovered, such as alkaloids, terpenoids and peptides, extracted from marine organisms. Marine fungi, especially in recent years, have become a significant subject of interest due to their ability to produce secondary metabolites with unique chemical structures and powerful biological properties [1]. Marine-derived strains of Clonostachys rosea have been found to produce peptaboils, a group of linear peptide antibiotics characterized by non-proteinogenic amino acids [2]. These compounds exhibit strong antifungal and antibacterial activity. Their unique structures and potent bioactivity make them attractive candidates for pharmaceutical development, especially in the search for new antibiotics and antifungal agents. This work is part of a multidisciplinary project, founded by Italian MIUR PRIN 2022, aimed to find new bioactive molecules from extremophilic marine fungi active against emerging or multi-resistant pathogens. This poster shows the extraction, molecular networking, bio guided assay and OSMAC approach used for the identification of a new library of peptaboils from Clonostachys rosea ([Fig. 1])
Membro del Gruppo di Riesame (GRIE) del Corso di Studi in Scienze dei servizi giuridici (classe L-14), Dipartimento di Giurisprudenza dell’Università degli Studi di Napoli “Federico II”
No full textA Sraffian Approach to the Relationship Between the Interest Rate and the Profit Rate
No full textThis paper seeks to offer an innovative interpretation of the relationship between
interest rate and profit rate, based on the profitability of bank capital and a rethinking
of the traditional multi-sectoral depiction of the economy. That is, considering the
banking sector as a particular ‘productive’ sector with a specific price equation. The
Sraffian-type price equation tool is used to study and represent this relationship within
the framework of the Sraffian ‘Marxian’ approach of Garegnani. In order to describe the
functioning of the banking sector with such a tool, a careful analysis of the necessary
and normal coefficients of a banking sector price equation is conducted, while the
compatibility of economic concepts such as input, output and capital with endogenous
money theory is also discussed. The results of this investigation demonstrate that a
causal relationship exists between the rate of profit and the rate of interest, with the
central bank wielding significant influence. These findings can also reconnect and
develop the different cues in Marx’s analysis of the financial system—in particular,
the idea that the determination of the interest rate also depends on the conflict between
financial and productive capitalists
Design and evaluation of dual-functional aptamer-peptide conjugates as a platform for targeted cancer therapy
No full textAS1411 is a G-rich DNA aptamer that exhibits intrinsic antitumor activity through selective binding to nucleolin, a protein overexpressed in many cancers. Beyond its cytotoxic effects, AS1411 can also serve as an effective targeting ligand for the delivery of therapeutics with poor cellular uptake, including peptide-based drugs. One such candidate is the pro-apoptotic peptide KLA, which selectively disrupts mitochondrial membranes and induces apoptosis upon internalization. In this study, AS1411-KLA conjugates were designed and synthesized using strain-promoted azide-alkyne cycloaddition chemistry, incorporating protease-cleavable peptide linkers to enable intracellular release of both the aptamer and peptide as independent active units. Circular dichroism analysis showed that, in all constructs, the AS1411 domain preserved the characteristic G-quadruplex structural features, while surface plasmon resonance experiments revealed that all conjugates retained nucleolin binding. The biological activity of the conjugates was evaluated in MCF-7 breast cancer cells and in non-tumorigenic MCF-10A cells, and compared with that of the individual aptamer and peptide. One conjugate displayed an enhanced antiproliferative effect compared to the unconjugated components, underscoring the therapeutic potential of this modular design. Overall, this work demonstrates the potential of aptamer-peptide conjugates as a promising strategy for next-generation targeted cancer therapeutics, combining targeted delivery with synergistic therapeutic effects
Coordinatore del Comitato scientifico del gruppo di ricerca internazionale “Diritto penale e fattore religioso” dell’Istituto di ricerca interdipartimentale “Alimena” dell’Unical.
No full textEutimio Zigabeno interprete dell tradizione paolina: profili giuridici della lotta all'eresia in età comnena
No full textFood allergy‐related bullying in children: Prevalence and psychosocial burden from a mixed‐methods study
No full textBackground: Food allergy-related bullying (FARB) is an underrecognized phenomenon that combines the psychosocial harm of peer victimization with the potential for serious physical consequences from allergen exposure. Despite its relevance, data on FARB in Italy are scarce. This study aimed to investigate the prevalence, forms, and lived experiences of FARB among school-aged children and adolescents with food allergy (FA) using a mixed-methods approach. Methods: We conducted an observational cross-sectional study between June 2023 and April 2024 at a tertiary Pediatric Allergy Unit in Naples, Italy, adopting a sequential explanatory mixed-method design. Quantitative data on bullying prevalence were collected using the Italian-adapted Olweus Bully/Victim Questionnaire. Qualitative data were obtained through semi-structured interviews and analyzed using Interpretative Phenomenological Analysis to explore emotional impact, coping strategies, and perceived support. Results: Seventy-three children with FA (mean age 10.6 years; 69.9% male) were included. In the previous 2 months, 35.6% reported at least one bullying episode, and 27.4% identified FA as the specific motive. FARB most frequently involved verbal insults, social exclusion, and rumor spreading, mainly occurring in classrooms and perpetrated by small peer groups. Only 60% of affected children reported the episodes, primarily to parents. Qualitative findings highlighted emotional distress, hypervigilance, social withdrawal, inconsistent adult responses, and a strong desire for greater school awareness and protection. Conclusions: FARB is a frequent and multifaceted form of victimization with relevant psychosocial and potential physical implications. Preventive strategies should integrate FA management into school-based anti-bullying policies, staff training, and inclusive educational interventions
