120589 research outputs found
Sort by
Advances in Cell-Penetrating Poly(disulfide)s
No full textCell-penetrating poly(disulfide)s (CPDs) can be considered as a good candidate for a general method for intracellular delivery of a substrates of interest. However, CPDs are still not fully understood and suffer from lack of ease-of-use, limiting their common application. This thesis aims to further develop CPDs by tackling their key limitations, enabling their use to solve the daily delivery problems of tomorrow. Firstly, a new dynamic conjugation was introduced to make it easier to attach substrates containing a thiol or disulfide to a CPD, at competitive rates of 1500 M-1s-1. Then, the mode of action of CPDs was elucidated in part, uncovering that CPDs interact mainly with protein disulfide isomerase A3 to penetrate the cells by thiol-mediated uptake. Lastly, the templated ring-opening polymerization of cyclic disulfide was attempted on an oligonucleotide template, leading to the exploration of CPDs with alternative backbones, based on thiolactone and asparagusic monomers
Le contexte archéologique régional : la vallée du Furon et ses marges du Paléolithique supérieur aux âges des Métaux
No full text
Short-Term 24h Dietary Recalls from Observational Studies Cannot Support Claims on Mortality
No full textBiodegradation of ciprofloxacin by <i>Exiguobacterium </i>sp. from tropical river sediments: an integrated approach
No full text
Enjeux de sexe et de genre dans l’organisation de la médecine de demain*
No full textLa médecine évolue avec une féminisation croissante et l’émergence de nouveaux modes de travail. Les femmes sont majoritaires parmi les diplômé-es mais sous-représentées aux postes de cadres et dans les spécialités à plus haut revenus. Pour répondre à ces défis économiques et organisationnels, cet article propose des pistes d’actions. En plus d’une augmentation globale des places de formation médicale pour pallier les départs en retraite et du développement de structures interprofessionnelles de soins intégrés, un soutien aux promotions académiques et aux positions de cadres pour les femmes ainsi qu’une revalorisation financière des activités professionnelles et non rémunérées sont autant de solutions à envisager. Ces changements assureront une médecine inclusive, de plus grande efficience et de qualité.Medicine is evolving with increasing feminization and the rise of part-time work. Women now outnumber men among graduates but are underrepresented in leadership roles and in the highest-paid specialties. To meet these economic and organisational challenges, this article proposes a number of courses of action. In addition to an overall increase in the number of medical training places to compensate for retirement and the development of interprofessional integrated care structures, support for academic promotion and management positions for women, as well as an increase in the financial value of professional and non-remunerated activities, are all solutions to be considered. These changes will ensure that medicine is inclusive, efficient and of high quality