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Pengaruh Metode Ekstraksi terhadap Kadar Fenol dan Flavonoid Total, Aktivitas Antioksidan serta Antilipase Daun Jati Belanda (Guazuma ulmifolia)
Get PDFThe leaf of Guazuma ulmifolia has been used traditionally for antiobesity. The activity of antiobesity was affected
by the content of bioactive compounds. Extraction is the primary step to obtain bioactive compounds from plant material. The method and solvent used for extraction are crucial factors to produce extracts that have a high amount of active compounds. This study aims to determine the total phenolic and total flavonoids content from ethanolic extracts, water extract, and infusions of G.
ulmifolia leaf and to evaluate the antioxidant and antilipase activity. Folin-Ciocalteu method was used to determine the phenolic content, while flavonoid content determination was done using aluminium chloride colorimetric assay. The antioxidant activity
was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antilipase activity was quantified using p-nitrophenol release from p-nitrophenyl butyrate (p-NPB) substrate-colorimetric assay. The result of G. ulmifolia leaf extraction showed that the highest yield was obtained from water extraction (10.50%). Whereas, the ethanolic extract was showed the highest total phenolic content (67.761±1.811 mg GAE/g extract) and the highest total flavonoid content (124.643 ± 1.033 mg QE/g extract). The same extract also exhibited the highest antioxidant activity (IC50 = 6.544 ± 0.271 µg/mL) and antilipase activity (IC50 = 307.280 ± 21.430 µg/mL)
Formulation of Eel (Monopterus albus) extract membranes for wound dressing using plasticizers
Get PDFThe types of wound dressing will affect wound healing processes. The membrane is one of the potential wound
dressing that can maintain the moisture of the wound surface. The eel extract as an active ingredient could be added to the membrane formula to accelerate wound healing. This study aimed to formulate eel (Monopterus albus) extract membranes for wound dressing using some plasticizers. Polyvinyl alcohol (PVA) 146,000 was used as the polymer, while glycerol, propylene glycol, and polyethylene glycol (PEG) 400 were used as the plasticizers. Methylparaben and propylparaben were added as preservatives. Evaluations included thickness, water vapor permeability, and mechanical properties of the membranes that consisted of tensile strength, elongation at break, and Young's modulus were performed. The result showed that the use of different types of plasticizers affected the mechanical properties of the eel extract membrane. The formula that used glycerol as the plasticizer produced membranes with the best water vapor permeability and mechanical propertie
