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-The practice of suicide prevention in Aomori Prefecture and issues that have to be tackled in future-
publisher青
Why Was Socrates Killed? - With Reference to Kierkegaard's "Philosophical Fragment" -
publisher青森 ソクラテスはなぜアテナイ市民から死刑判決を受け、殺されたのであろうか?魂は何度となく生まれ変わっているのであり、だから何が真理であるかを魂は実は全て知っているのであり、ただ忘れているだけなのである。だから、それを思い出させてやればいいだけなのである、というソクラテスの想起説がもし本当に正しかったとするならば、なぜソクラテスは対話相手から憎悪されたのであろうか?ソクラテスは自分が真理と思っているものを相手に無理に押しつけたわけではない。真理は元々相手の心の中にあったのである。ソクラテスはそれを引き出したに過ぎない。鍵は、忘れていたかったことを思い出させたということにある。忘れたという形で覚えているというこの微妙な自己欺瞞にある。本稿ではキルケゴ−ルの『哲学的断片』を用い、なぜソクラテスは相手から憎悪を引き出してしまったのか、この問題を探る。
Why was Socrates executed? In this paper I consider this problem with reference to Kierkegaard's "Philosophical Fragment". If Socrates' theory of recollection was correct, it is difficult to understand why Socrates was hated by his partner in dialogue after helping to remember the truth which was only sleeping in his mind. Here Kierkegaard's point that man opposes the truth is very helpful. Man
forgets the truth because he wants to forget it. But Socrates compels him to remember the truth, so the partner is angered by Socrates who breaks the good balance of remembrance and forgetting. Perhaps, strange as it may sound, man has to remember the truth in order to forget it. In order to forget the truth, man always needs to watch it carefully so that it may not rise to the surface of his
consciousness. Even Socrates had a fear of the fury of his partner, but Socrates endured it and continued his dialogue. Usually we learn to hold our tongue to tell the truth in front of the subtle angry look which comes over the partner's face. It is a social rule of mankind. But Socrates disregarded this fundamental rule, so he was sentenced to death
もち性小麦新品種「もち姫」による新たな地域特産商品開発を目指した産学官連携(特集1 2010年度青森県保健医療福祉研究発表会シンポジウム 保健大学の産学官連携活動による社会貢献)
publisher青
A mentally disabled person's working image which the institution personnel who are performing the mentally disabled person's vocational support consider to be an ideal.
publisher青森
Kango kanrisha no kyaria o keiseisuru keikan karano gakushu ni kansuru kenkyu
[青森]取得学位:博士(健康科学)
報告番号:甲第7号
学位授与年月日:平成22年3月18日
指導教員:上泉和
Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension ; koketsuatsu moderu ratto no sanka sutoresu oyobi ensho niokeru azuki ( Vigna angularis ) porifwenoru no seiriteki yakuwari
[青森]取得学位:博士(健康科学)
報告番号:甲第10号
学位授与年月日:平成22年3月18日
指導教員:佐藤伸List of Tables
List of Figures
Abstract
Chapter 1. General Introduction
Chapter 2. Supression of vascular and renal oxidative stress
2.1 Effect of azuki bean seed coats (ABSC) on superoxide production in
spontaneously hypertensive rats
2.2 Effect of azuki bean extract (ABE) on nitric oxide metabolism in
spontaneously hypertensive rats
2.3 Discussion
Chapter 3. Supression of vascular inflammation
3.1 Effect of azuki bean seed coats (ABSC) on vascular inflammation in
spontaneously hypertensive rats
3.2 Discussion
Chapter 4. General Discussion
Chapter 5. Conclusion
Acknowledgements
ReferencesThe aim of the present study was to examine whether azuki bean polyphenols would contribute to attenuation of hypertension, if so, to clarify the physiological role in oxidative stress and inflammation with hypertension.
Male spontaneously hypertensive rats/Izumo (SHR) and control normotensive WKY/Izumo (WKY) rats were randomly divided into 2 groups each, treated or untreated with polyphenols-containing azuki bean seed coats (ABSC) or extract (ABE). When the systolic blood pressure of SHR reached approximately 200 mmHg, they were administered each diet for 8 weeks. The blood pressure and heart rate were measured once every 2 weeks by the tail-cuff plethysmography method. The nitric oxide (NO) content in 24-h urine was measured by Griess method. After sacrifice, superoxide (O2) production in aorta was determined using a lucigenin-enhanced chemiluminescence technique. Vascular mRNA levels of NADPH oxidase subunits, Nox4, p47phox and p22phox, and monocyte chemoattractant protein 1 (MCP-1) and its receptor CCR2 were respectively analyzed by real-time RT-PCR. Vascular or renal protein levels of superoxide dismutase (SOD), endothelial NO synthase (eNOS), cavelin-1, inducible NOS (iNOS) and cyclooxygenase 2 (COX-2) were respectively analyzed by western blotting.
Azuki bean polyphenols such as procyanidin and catechin, contained in ABSC and ABE, reduced the elevated blood pressure in long-term treatment of SHR. ABSC treatment decreased the vascular production of O2, and suppressed the mRNA expression of the p47phox subunit of NADPH oxidase in the aorta. ABE treatment increased the renal Cu/Zn-SOD expressions. ABE treatment increased the urinary NOx content, indicating an increased NO production. ABE treatment modulated the eNOS and caveolin-1 expressions in the aorta and kidney of SHR. ABSC treatment suppressed the mRNA expressions of MCP-1, its receptor CCR2, and the protein expression of MCP-1. ABSC treatment suppressed the protein expressions of iNOS and COX-2 in the aorta of SHR. In conclusion, azuki bean polyphenols were showed to contribute to attenuation of oxidative stress and inflammation with hypertension. These effects may lead to prevention of NO inactivation and immune cells infiltration, associated with amelioration of endothelial dysfunction.博士(健康科学)青森県立保健大
Ikikito seikatsusuru tameni nambyo to tomoni ayumu
publisher[青森]平成21年度青森県立保健大学地域連携・国際センター研修科によるブックレット作成事業により作成された。自分の病気を知ろう
自分の活動状況を把握しよう
心の健康
廃用症候群の予防
身体の動かし方
パーキンソン病の場合I
パーキンソン病の場合II
パーキンソン病の場合III
脊髄小脳変性症・多系統萎縮症の場合I
脊髄小脳変性症・多系統萎縮症の場合II
脊髄小脳変性症・多系統萎縮症の場合III
朝の体操
椅子にすわっての体操
椅子からの立ち上がり
椅子を使った体操
必要なら歩く習慣を
地域でのイベントに参加しましょう
日常の過ごし方
さいご
Shinjin kango shokuin kenshu no arikata ni kansuru kenkyu chosa kekka hokoku daijesutoban
Research team headpublisher[青森]平成21年度厚生労働科学研究補助金(特別研究事業)研究報告書「新人看護職員研修のあり方に関する研究」のダイジェスト
Physiological roles of azuki bean (Vigna angularis) polyphenols in oxidative stress and inflammation in rats with hypertension ; koketsuatsu moderu ratto no sanka sutoresu oyobi ensho niokeru azuki ( Vigna angularis ) porifwenoru no seiriteki yakuwari
[青森]取得学位:博士(健康科学)
報告番号:甲第10号
学位授与年月日:平成22年3月18日
指導教員:佐藤