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Striking tick-borne virus diversity and potential reservoirs documented during One-Health-based cross-sectional screening in Anatolia
No full textBackgroundAn expansion of recently described human pathogenic tick-borne viruses from Central Asia toward Europe has been documented. Located on important bird migration routes, Anatolia is an intercontinental crossing hub with various climactic zones and with an abundance of endemic tick species. We sought to investigate tick-borne viruses utilizing a One Health approach encompassing host-removed ticks and host samples.MethodsWe collected host-attached ticks and accompanying plasma in 2023-2024 at locations in 20 provinces representing the 7 distinct geographical regions in Anatolia. The hosts comprised cattle, sheep, dogs, goats, and tortoises. The ticks were morphologically identified, processed in pools, and these pools, along with plasma from cattle, sheep and goats, were subjected to nucleic acid purification and complementary DNA synthesis. Viruses were screened by generic (nairovirus) and specific (Jingmen tick virus, JMTV; Tacheng tick virus 1, TcTV-1; Tacheng tick virus 2, TcTV-2; and Tamdy virus, TAMV) amplification assays and characterized by sequencing.ResultsA total of 93 animal plasma samples and 1265 samples from 11 tick species were screened in 192 pools. Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in five tick species in ten pools (5.2%). Three distinct virus lineages, including Europe 1 and 2, as well as Africa 1, were noted. TcTV-1 was identified in 6 tick species in 12 pools (6.3%) and in a cattle plasma sample. Analysis of the nucleoprotein-encoding sequences revealed two separate virus clades, distinct from those reported from Asia and Europe. TAMV was identified in two tick species (1%). We further detected JMTV in 7 pools (3.6%), with sequences forming a new clade phylogenetically closer to viruses of Asian origin than local strains. Finally, highly divergent sequences of a novel nairovirus, forming a distinct group sharing ancestors with TcTV-1, TAMV, and pangolin/tick-associated nairoviruses, was observed in four pools (2%), comprising Haemaphysalis parva ticks.ConclusionsWe described a previously undocumented diversity of tick-borne viral pathogens, CCHFV, TcTV-1, and JMTV, in Anatolia. Possible animal reservoirs of TcTV-1 were identified. These pathogens and TAMV should be considered in the diagnostic workup of cases with symptoms associated with tick bites and in future surveillance efforts.Smithsonian InstitutionAll or portions of the laboratory and/or data analysis were conducted in and with the support of the Laboratories of Analytical Biology (https://ror.org/05b8c0r92) of the Smithsonian Institution
Coğrafya öğretiminde mekânsal düşünme beceri testi geliştirme
No full textThis study aimed to develop a test to measure university students’ spatial thinking skills. The research was conducted using a survey design, with a sample of 260 undergraduate students from geography teaching and geography departments. GIS software was used to incorporate maps and satellite images, enhancing the spatial representation in the test. The test was administered online.. Item analysis was conducted for each question item, and items with a difficulty index above 0.70 and a discrimination index below 0.19 were removed from the test. Additionally, the scores of the lower and upper groups were compared using an independent samples t-test. Exploratory factor analysis (EFA) based on the tetrachoric correlation coefficient was performed to assess the construct validity of the test. This analysis yielded a single-factor structure that accounted for 30% of the total variance. Items with unsatisfactory factor loadings were also removed. The internal consistency coefficient calculated using the KR20 formula yielded a value of 0.83. . The stability of the test was assessed using the test-retest method, confirming its stable structure. With these refinements, the test was finalized with 26 items. The study concluded that the developed test is a valid and reliable tool for measuring spatial thinking skills among undergraduate students studying geography or geography teaching.Bu çalışmada, üniversite öğrencilerinin mekânsal düşünme becerilerini ölçmek amacıyla bir test geliştirmek hedeflenmiştir. Araştırma, coğrafya öğretmenliği ve coğrafya bölümlerinden 260 lisans öğrencisiyle, tarama deseni kullanılarak yürütülmüştür. CBS yazılımı kullanılarak teste harita ve uydu görüntüleri eklenmiş ve mekânsal temsil güçlendirilmiştir. Test çevrim içi olarak uygulanmıştır. Soru maddelerinin her birine madde analizi yapılmıştır. Madde güçlüğü 0.70’in üzerinde olan soru maddeleri ve madde ayırt ediciliği 0.19’un altında olan soru maddeleri testten çıkarılmıştır. Ayrıca, alt ve üst grupların puanları bağımsız örneklem t-testi ile karşılaştırılmıştır. Testin yapı geçerliğini değerlendirmek için tetrakorik korelasyon katsayısına dayalı açımlayıcı faktör analizi (AFA) yapılmıştır. Bu analiz, toplam varyansın %30'unu açıklayan tek faktörlü bir yapı ortaya koymuştur. Düşük faktör yüküne sahip maddeler testten çıkarılmıştır. Testin iç tutarlılığı KR20 formülü ile hesaplanmış ve 0.83 bulunmuştur. Testin kararlılığı test-tekrar test yöntemiyle değerlendirilmiş ve kararlı bir yapıda olduğu doğrulanmıştır. 31 madde olarak tasarlanan testten yapılan istatistiksel analizler sonunda toplam 5 madde çıkarılmıştır. Testin son hali 26 maddeden oluşmaktadır. Araştırma sonucunda, geliştirilen testin coğrafya ve coğrafya öğretmenliği lisans öğrencilerinin mekânsal düşünme becerilerini ölçmede geçerli ve güvenilir bir araç olduğunu sonucuna varılmıştır
Can Fintech indices hedge VIX and global banking volatility? Evidence from a dynamic short-term perspective
No full textAlthough many researchers have increasingly analyzed the diversifier, hedge, and safe-haven features of cryptocurrencies, very few studies have investigated the hedging issue of FinTech assets with other assets. This paper analyses if FinTech indices could hedge the uncertainties in different markets in the context of global and banking sector volatilities. The connection between cryptocurrencies and FinTech indices lies in their shared role in financial innovation and market disruption. Both asset classes represent emerging financial technologies that challenge traditional financial systems by offering alternative investment opportunities, payment solutions, and risk diversification strategies. The cADCC-GARCH (corrected Asymmetric Dynamic Conditional Correlation-Generalized Autoregressive Conditional Heteroscedasticity) model is considered the most adequate choice to estimate appropriately and model correlations among different assets. Using such a framework allows us to better set up dynamic hedge ratios and then time-varying cross-hedging FinTech/stock markets. Our results display the time-varying correlations among different assets, showing a dynamic behavior of the linkages between FinTech indices and GLBLBNK/VIX. Such finding displays that such relationship trending down(up)wards over the period under consideration, particularly during the adverse events. We also report dynamic optimal hedge ratios which imply an ongoing regular demand for rebalancing the hedged positions. Such findings have insightful information for investors and portfolio managers. This research adds to the continuing discussion about how the COVID-19 pandemic and the Russia–Ukraine war have affected the financial market, portfolio composition, and hedging options during these crises. Our findings underscore the distinctive features of Fintech within itself and its significance in international portfolio diversification, particularly under the influence of global adverse events. Our findings have significant implications for developing an efficient diversification strategy. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2025
Investigation of the relationships between workaholic, work engagement and organizational commitment levels of academicians
No full textGünümüzde işletmelerin karşı karşıya olduğu en önemli sorunlardan biri sürdürülebilir rekabet avantajı sağlayacak nitelikli çalışanlarını elde tutabilmek ve bu çalışanların işlerini maksimum enerji ve istekle yapmalarını sağlayabilmektir. Örgütsel bağlılık ile işe bağlılık bu noktada bir arada ele alınması gereken kavramlar olarak karşımıza çıkmaktadır. Bu araştırmanın ilk amacını akademisyenlerin örgütsel bağlılık, işe bağlılık ve işkoliklik seviyeleri arasındaki ilişkileri ortaya koymak oluşturmaktadır. Örgütsel bağlılık, işe bağlılık ve işkoliklik kavramları çalışma şartlarına göre şekillenmektedir. Özellikle özlük hakları, çalışma şartları, iş yükü, iş güvencesi gibi açılardan farklılık gösteren grupların örgütsel bağlılık, işe bağlılık ve işkoliklik seviyelerinin farklılaşıp farklılaşmadığının tespiti önemlidir. Bu doğrultuda araştırmanın ikinci amacı akademisyenlerin örgütsel bağlılık, işe bağlılık ve işkoliklik seviyelerinin çalıştıkları üniversitenin türüne göre anlamlı bir farklılık gösterip göstermediğini tespit etmektir. Araştırmada 1436 akademisyene anket uygulanması yolu ile veri toplanmıştır. Araştırma verilerinin analizinde Pearson korelasyon, bağımsız örneklem t, geçerlilik ve güvenilirlik analizleri uygulanmıştır. Gerçekleştirilen analizler sonucunda akademisyenlerin ‘’örgütsel bağlılık ile işe bağlılık seviyeleri’’ arasında ‘’örgütsel bağlılık seviyeleri ile işkoliklik seviyeleri’’ arasında ‘’işkoliklik seviyeleri ile işe bağlılık seviyeleri’’ arasında anlamlı ilişkiler tespit edilmiştir. Ayrıca akademisyenlerin işe bağlılık seviyeleri çalıştıkları kurumun türüne göre anlamlı bir farklılık gösterirken; örgütsel bağlılık ve işkoliklik seviyeleri açısından ise çalışılan kurumun türüne göre anlamlı bir farklılık tespit edilmemiştir.The first purpose of the research is to reveal the relationships between academicians' levels of organizational commitment, job involvement, and workaholism. Organizational commitment, work commitment and workaholism,, are shaped according to working conditions. Employees' organizational commitment, work commitment and workaholism levels may vary in terms of factors such as personal rights, working conditions, workload and job security. In this regard, it is important to determine whether the characteristics of the institution people work in make a difference in terms of the variables in question. In this context, another aim of the research is to examine academics' organizational commitment, job engagement and workaholism levels differ significantly depending on the type of university they work at. In the research, a survey was administered to 1436 academicians. As a result of the study, significant relationships were determined between academicians' levels of organizational commitment and job engagement, levels of organizational commitment and workaholism, and levels of workaholism and level of commitment to work. Additionally, academics' job engagement levels vary significantly depending on their institution. The fact that no study has been conducted with such a large sample group, and the fact that the subject is not examined comparatively between foundation and state universities constitute the originality of the research
The Effect of Carob Aqueous Extract on Oxidative Stress, Proinflammatory Cytokines, Glucose and Lipid Concentrations in the Blood of Diabetic Rats.
Get PDFHerbal treatments offer potential benefits in controlling blood glucose levels and preventing diabetes-related complications. This study was conducted to determine the effects of application of an aqueous extract of carob fruit prepared by ultrasonic- assisted extraction (UAE) method on oxidative stress, glycemic level, pro-inflammatory cytokines and lipid profile levels in the blood of rats induced experimental diabetes with streptozotocin-nicotinamide (STZ-NA) model. Forty male Wistar Albino (200-250 g live weight) animals used in the study were divided into four groups as normal control, diabetic control, normal group given 200 mg.kg-1 carob aqueous extract and diabetic group given 200 mg.kg-1 carob aqueous extract. At the end of the 21-day study, plasma glucose, hemoglobin A1C (HbA1c), insulin, homeostatic model assessment of insulin resistance (HOMA- IR), malondialdehyde (MDA), reduced glutathione (GSH), proinflammatory cytokines interleukin-1beta (IL-1?), tumor necrosis factor-alpha (TNF-?), interleukin-6 (IL-6), total cholesterol, triglyceride, leptin and 25-hydroxy vitamin D levels were measured in blood samples taken from all animals. Treatment of carob aqueous extract did not cause a significant decrease in high glucose, HbA1c and HOMA-IR values caused by diabetes. The blood insulin levels were not affected by the treatments. Diabetes increased MDA, IL-6 and triglyceride levels (p<0.05), while treatment of carob aqueous extract to diabetic animals did not affect these parameters. However, treatment of carob aqueous extract to diabetic animals increased GSH levels (p<0.05). The treatments had no effect on IL-1?, TNF-?, total cholesterol and leptin levels. We concluded that the carob fruit aqueous extract treatment had no effect on controlling hyperglycemia
Investigating the impact of behavioural economics psychological factors on digital consumer behaviour
No full textDijital tüketici davranışlarını tam olarak anlayabilmek için, sadece kullanıcıların ne yaptığını değil, neden yaptığını da incelemek gerekir. Bu çalışma, davranışsal ekonomi kuramlarına dayalı olarak, özellikle kayıptan kaçınma, çerçeveleme etkisi, çapa etkisi ve fırsat kaçırma korkusunun (FOMO), Afyonkarahisar’daki Amazon ve Trendyol kullanıcılarının satın alma niyeti, memnuniyeti ve sadakati üzerindeki etkilerini araştırmayı hedeflemiştir. Araştırma, özellikle iPhone kullancılar ve alışverişi yapan kişiler üzerinde yoğunlaşmıştır. Daha önce yapılan çalışmalardan faydalanılarak bir teorik altyapı oluşturulmuş ve analiz bu çerçevede yapılmıştır. Veriler, Google Forms ile hazırlanan ve katılımcılara çevrim içi olarak ulaştırılan yapılandırılmış bir anketle toplanmış ve 102 geçerli yanıt elde edilmiştir. Toplanan veriler SmartPLS yazılımı kullanılarak, faktör analizi ve yol modelleme yöntemleriyle analiz edilmiştir. Bulgular, bireylerin dijital ortamdaki alışveriş davranışlarının psikolojik önyargılardan ciddi şekilde etkilendiğini göstermektedir. Özellikle kayıptan kaçınma ve FOMO, satın alma niyetini önemli ölçüde etkilerken; çerçeveleme ve çapa etkisi ise memnuniyet ve sadakat ile yakından ilişkili bulunmuştur. Bu sonuçlar, dijital alışveriş platformlarının sadece pasif araçlar olmadığını, aynı zamanda kullanıcıların kararlarını zihinsel süreçler yoluyla yönlendirebildiğini ortaya koymaktadır. Araştırma sonuçları, dijital pazarlama alanında çalışanlar için kullanıcı psikolojisine uygun stratejiler geliştirme konusunda fikir vermekte ve davranışsal ekonomi literatürüne dijital ticaret alanında katkı sağlamaktadır.To truly understand digital consumer behavior, it’s essential to explore not only users’ actions but also the underlying reasons for those actions. This study explores the impact of behavioral economics principles, specifically loss aversion, framing effects, anchoring, and the fear of missing out (FOMO) on the purchasing intentions, satisfaction, and loyalty of Amazon and Trendyol users in Afyonkarahisar, focusing particularly on iPhone users. Based on previous studies, a theoretical framework was developed to guide the analysis. Data was collected through a structured survey distributed via Google Forms, resulting in 102 valid responses. The data were analyzed using SmartPLS, incorporating factor analysis and path modeling. The results indicate that psychological biases play a significant role in shaping online shopping behavior. In particular, loss aversion and FOMO had a notable influence on consumers’ intentions to purchase, while framing and anchoring were closely linked to their satisfaction and loyalty. These findings suggest that digital platforms are not neutral spaces; they actively influence consumer decisions through subtle cognitive effects. This study offers valuable guidance for digital marketers looking to boost engagement by aligning their platforms with users’ psychological tendencies. It also expands the field of behavioral economics by applying well-known decision-making biases to the context of modern e-commerce
Non-Porous Hydrogel Scaffolds for Locoregional Chemotherapy: A One-Pot Synthesis Approach
No full textAlthough surgery is common in the treatment of solid tumors in cancer, the risk of recurrence after operation is high in malignant tumors. This study focuses on fabricating doxorubicin-loaded, non-porous POEGMEMA (Poly(oligo(ethylene glycol) methyl ether methacrylate)) and PLGA (Poly(D,L-lactide-co-glycolide))/POEGMEMA scaffolds for locoregional chemotherapy. Polymer synthesis, hydrogel formation, and drug-loading processes are performed using a one-pot approach. The scaffolds were characterized by mechanical, swelling, degradation, and release tests. 10% PLGA content, causes PLGA/POEGMEMA scaffolds to give a 2.5 times lower swelling ratio and sixfold higher compression stress than POEGMEMA scaffolds. Also, PLGA addition causes an increase in the biodegradation half-life of POEGMEMA-based hydrogel scaffolds. While PLGA/POEGMEMA scaffolds exhibit a degradation-dependent release profile, POEGMEMA scaffolds give a burst release due to their high water uptake ratio. The burst release behavior of POEGMEMA scaffolds causes a high antiproliferative effect (viable cells: 5-10%) against HT-29 and MCF-7 cancer cells in the short term. In contrast, the controlled and sustained release profile of PLGA/POEGMEMA scaffolds shows an antiproliferative effect (viable cells: 50-60%) dependent on the release ratio. This hydrogel scaffold platform allows tuning physical and functional properties to deal with diverse physiological conditions at the region after tumor surgery for locoregional chemotherapy.Afyon Kocatepe University Scientific Research Projects Coordination Unit [22.FEN.BIdot;L.12]This study was supported by the Afyon Kocatepe University Scientific Research Projects Coordination Unit (Project No: 22.FEN.B & Idot;L.12)
Reliability based seismic slope failure assessment of a high concrete face rockfill dam close to an active fault zone
No full textThis study assesses the earthquake-induced failure risks of the upstream and downstream slopes of a concrete face dam (CFRD), which is under the influence of a nearby active fault, using the reliability-based analysis method. For this purpose, peak ground accelerations (PGAs) that may occur at the dam site were calculated probabilistically and their contribution to the sliding risks of dam slopes was determined in accordance with the conditional probability theorem. Upstream and downstream slopes of CFRDs are usually conventionally designed as 1.3-1.5H:1V and 1.3-1.6H:1V, respectively throughout the world. Such slope design is considered sufficient for almost every case. The findings of this study are fully applicable and very important for the structural design of all concrete-faced rockfill dams (CFRDs) worldwide. Since, the slope design of CFRDs is similar and usually traditionally (1.3-1.5H; 1V for upstream slope and 1.4-1.6H:1V for downstream slope). However, this study proves that only conventional upstream slope design (1.3-1.5H:1V) can be safe for even very high peak ground accelerations (PGAs) occurring due to a nearby active fault, but contrary to expectations, downstream slope of CFRDs cannot be sufficiently safe and maintain its slope sliding safety when PGAs reach high levels. When the critical PGA level is exceeded, the downstream slope carries the risk of losing its stability with high probability, as emphasized in this study. Therefore, this study provides a new design strategy and extremely important information for dam design engineers which is to design a rather flatter downstream slope such as 1 vertical to 1.8-2.0 horizontal or, instead, to design a downstream rockfill berm supporting conventional design if CFRDs are to be built in high seismic hazard potential areas or close to active faults. Suggested such type of designs will be economical and sufficiently safe. (c) 2025 Japanese Geotechnical Society. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/)
The understanding of divinity in Ibn Furek and al-Qushayri
Get PDFBu çalışmada ilk olarak özü itibariyle tevhîd kavramı ele alınmıştır. Bu bağlamda tevhîdin İslam öncesi dönemlerde ve İslam düşünce geleneği içerisindeki anlam ve konumu kısaca ortaya konmuştur. Çalışmanın ana temasını oluşturan, kelam âlimlerinden İbn Fûrek ve Kuşeyrî'nin hayatı, hocaları, talebeleri ve eserleri hakkında bir takım bilgilere yer verilerek, yaşadıkları dönem, fikri anlamda kimlerden ne şekilde etkilendikleri, yine yaşadıkları dönem itibariyle ve sonrasında kimleri hangi yönde etkiledikleri ortaya konulmaya çalışılmıştır. Tevhîd kavramına geniş bir perspektiften yaklaşılan bu çalışmada tevhîd kavramının İslam inancındaki tanımı, geçirdiği evreler, İslam kelam ekollerinin bu kavram üzerindeki anlayışları, tevhîd ile ilgisi bakımından sıfatlar meselesi; zâtî ve subûtî, fiilî ve haberi başlıkları altında genel çerçevede değerlendirilmiştir. Son olarak İbn Fûrek ve Kuşeyrî'nin ulûhiyyete dair görüşleri genel çerçevede; Allah'ın varlığı ve delilleri, Allah'ın birliğinin delili, Allah'ın sıfatları başlığı altında değerlendirilmiş, zâtî ve subûtî, fiilî ve haberi sıfatlar ise Allah'ın sıfatları başlığı altında incelenmiştir. Bu başlıklar bağlamında eserlerindeki değerlendirmeleri ve bu konuyla ilgili kavramlara bakış açıları ayrıntılı bir şekilde ele alınmıştır. Sonuç kısmında âlimlerimizin tevhîd anlayışları karşılaştırmalı olarak analiz edilmeye çalışılmıştır. Her iki âlimin eserlerinden hareketle tevhîd ve sıfatlar konularındaki görüşleri, metodolojik yaklaşımları ve delillendirme biçimleri değerlendirilmiştir. Aynı zamanda içerisinde yaşamış oldukları tarihsel ve ilmî şartların, fikirlerine nasıl yansıdığı üzerinde de durulmuştur. Bu bölümdeki analizler, eleştirel ve mukayeseli bir değerlendirme çerçevesinde sunulmuştur.In this study, the concept of taw??d is first examined in its essence. In this context, the meaning and position of taw??d in the pre-Islamic period and within the tradition of Islamic thought are briefly discussed. The main theme of the study focuses on providing certain information about the lives, teachers, students, and works of the theologians Ibn F?rak and Qushayr?. The study also explores the intellectual influences they received during their lifetimes and the individuals they, in turn, influenced both during and after their lives. Taking a broad perspective on the concept of taw??d, the study addresses the definition of taw??d in Islamic theology, its historical development, and the interpretations of different Islamic theological schools. The issue of divine attributes in relation to taw??d is evaluated under the categories of essential (dh?t?) and affirmative (?ub?t?), active (fi?l?) and transmitted (khabar?) attributes. Finally, the views of Ibn F?rak and Qushayr? on dıvınıty are examined under general themes such as the existence of God and its proofs, the evidence for the oneness of God, and the attributes of God. The essential, affirmative, active, and transmitted attributes are analyzed under the broader heading of divine attributes. Their evaluations in their works and their perspectives on related concepts are explored in detail. In the conclusion, the taw??d understandings of the two scholars are comparatively analyzed. Based on their works, their views on taw??d and divine attributes, their methodological approaches, and their use of evidences are assessed. Moreover, attention is given to how the historical and intellectual conditions they lived in were reflected in their thought. The analyses in this section are presented within a critical and comparative framework
The impact of sectoral specialization and financial performance on the sustainability of companies in the TR33 region
No full textUzun vadeli stratejik ve finansal planlamanın ön koşulu olan sürdürülebilir büyüme, şirketlerin değer yaratarak uzun vadede varlığını sürdürmesini esas alan geleceğe yönelik bir kavramdır. Bu makalenin temel amacı, TR33 bölgesinde faaliyet gösteren ve Borsa İstanbul Endeksi’nde listelenen şirketler sürdürülebilir büyüme oranı çerçevesinde karşılaştırmak ve sürdürülebilir büyüme oranı üzerinde etkisi olan göstergeleri belirlemektir. Sürdürülebilir büyüme oranını etkileyen faktörleri kapsamlı bir şekilde analiz etmek için geliştirilen model tahmini sabit etkiler yöntemi kullanılmıştır. Analizler, Borsa İstanbul’da endekslenen TR33 bölgesindeki şirketlere ait 2017-2023 yılları arasındaki sekiz yıllık döneme ait 280 gözleme dayanmaktadır. Elde edilen sonuçlar, borçlanma oranının sürdürülebilir büyüme oranı üzerinde olumsuz bir etkiye sahip olduğunu, kârlılığın ve varlık devir hızının ise sürdürülebilir büyüme üzerinde olumlu etkisi olduğunu göstermiştir. Ayrıca şirket büyüklüğünün ve kaldıraç oranının sürdürülebilir büyüme oranı üzerinde anlamlı bir etkisi olmadığını göstermiştir. Bu çalışma şirket yöneticilerine ve diğer karar alıcılara mali zorluklar yaşamadan sağlıklı bir şekilde büyümeyi sağlaması konusunda fikir vermesi beklenmektedir. Ayrıca, tüm iç ve dış paydaşlara şirket büyüme planlarının gerçekliği ve gelecekteki sürdürülebilir büyüme fırsatları hakkında iç görü sağlaması ve bir şirketin uzun vadeli performansını tahmin etmek için bir temel oluşturması umulmaktadır.Sustainable growth, which is a prerequisite for long-term strategic and financial planning, is a future-oriented concept that focuses on companies creating value and securing their existence in the long term. The main objective of this article is to compare companies operating in the TR33 region and listed in the Borsa Istanbul Index within the framework of the sustainable growth rate and to determine the indicators that have an impact on the sustainable growth rate. The fixed effects method of model estimation was used to comprehensively analyze the factors affecting the sustainable growth rate. The analyses are based on 280 observations of companies from the TR33 region listed in the Borsa Istanbul Index for the eight-year period between 2017 and 2023. The results obtained show that leverage has a negative effect on the sustainable growth rate, while profitability and asset turnover have a positive effect on sustainable growth. It was also shown that company size and leverage ratio have no significant effect on the sustainable growth rate. The expected that this study will give company managers and other decision-makers ideas on how to achieve healthy growth without getting into financial difficulties. It will also be hoped to provide all internal and external stakeholders with an insight into the reality of the company's growth plans and future sustainable growth opportunities and provide a basis for predicting a company's long-term performance