81690 research outputs found
Sort by
産業用ロボット企業の競争優位に関する研究 : 世界３大ロボット企業の比較分析 [全文の要約]
No full textこの博士論文全文の閲覧方法については、以下のサイトをご参照ください。https://www.lib.hokudai.ac.jp/dissertations/copy-guides
Study of the Involvement of Serum FGF21 in Lenvatinib-Induced Appetite Loss and Prognosis of Immune Checkpoint Inhibitor Therapy in Patients with Unresectable Hepatocellular Carcinoma [an abstract of dissertation and a summary of dissertation review]
No full text配架番号：289
Predicting treatment efficacy and prognosis using imaging analysis in rheumatic diseases [an abstract of dissertation and a summary of dissertation review]
No full text配架番号：289
Ⅱ型糖尿病モデルSpontaneously Diabetic Torii-Leprfa (SDT-fa/fa)ラット大腿骨の組織化学的解析
No full textTo elucidate the mechanisms underlying diabetic osteoporosis, we conducted a comprehensive histological examination of the femora in Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rats, an established model for obesity-related type 2 diabetes. Femora from 12 30-week-old male SDT-fa/fa rats and age-matched Sprague–Dawley (SD) rats (controls) were used for detailed histochemical analyses, including TRAP, cathepsin K, ALP, PHOSPHO1, DMP-1, MEPE, sclerostin, and osteocalcin staining, as well as silver impregnation, von Kossa staining, and micro-CT imaging. Micro-CT and hematoxylin-eosin staining demonstrated significantly reduced trabecular bone volumes in the femoral metaphyses of SDT-fa/fa rats. While the number of TRAP-positive osteoclasts per bone surface (/BS) remained comparable between the two groups, SDT-fa/fa rats exhibited reduced areas of ALP-positive osteoblasts/BS and PHOSPHO1-reactive mature osteoblasts/BS. Silver impregnation revealed a well-organized osteocytic lacunar–canalicular system in both groups; however, immunostaining identified aberrant DMP-1 and MEPE expression localized predominantly in lacunae in SDT-fa/fa rats, whereas in SD rats, these peptides were evident in both lacunae and canaliculi. Additionally, intense osteocalcin and sclerostin immunoreactivity was detected in osteocytes, along with a higher proportion of osteocalcin-positive osteocytes, in SDT-fa/fa rats, distinguishing them from SD controls. In conclusion, SDT-fa/fa rats display a notable decline in osteoblastic function and distinctive distribution patterns of osteocyte-derived peptides, suggesting that this diabetic model may manifest alterations in osteoblastic activity and the osteocytic lacunar-canalicular network
睡眠時ブラキシズムの日間変動とその関連因子の実態解明 [全文の要約]
No full textこの博士論文全文の閲覧方法については、以下のサイトをご参照ください。https://www.lib.hokudai.ac.jp/dissertations/copy-guides
種間相互作用と共存の状況依存性 : 岩礁潮間帯の2種系における空間スケールにまたがる複数の環境変数の影響 [全文の要約]
No full textこの博士論文全文の閲覧方法については、以下のサイトをご参照ください。https://www.lib.hokudai.ac.jp/dissertations/copy-guides
CdSe-CdSおよびFAPbBr₃ナノ結晶集合体から分子受容体への光誘起電子移動の研究 [全文の要約]
No full textこの博士論文全文の閲覧方法については、以下のサイトをご参照ください。https://www.lib.hokudai.ac.jp/dissertations/copy-guides
