994 research outputs found
Beyond the average: Choosing and improving statistical methods to optimize inference from complex neuroscience data
Full text linkVerhage, M. [Promotor]Sluis, S. van der [Copromotor
General cognitive ability and the interplay between genes and environment: ZIE STATUS/PROEFSCHRIFT ivm. (administratieve) toerekening van deze promotie aan FPP ipv. ALW
Full text linkVerhage, M. [Promotor]Heutink, P. [Promotor]Posthuma, D. [Copromotor]Sluis, S. van der [Copromotor
Duwvaartsluis stuwcomplex Lith
No full textIn de rivier de Maas ligt, ongeveer 15 Km ten noord-oosten van 's-Hertogenbosch, het stuwcomplex Lith. Het complex dateert uit 1934 en bestaat uit een schuifstuw met ten zuiden daarvan een schutsluis. De capaciteit van deze oude sluis is te klein voor het huidige aanbod van schepen en met de komst van de duwvaart op de Maas voldoet de sluis niet aan de eisen m.b.t. de kolkafmetingen. Een extra sluis leek de beste oplossing. Deze moest geschikt zijn voor het schutten van één duwvaartcombinatie bestaande uit twee achter elkaar geplaatste duwbakken. Voor de locatie van de duwvaartsluis waren in eerste instantie drie alternatieven beschikbaar: ten noorden van het complex, ten zuiden van het complex of op het eiland tussen de stuwen de oude sluis. Het eerste alternatief werd verworpen daar er op die locatie een waterkrachtcentrale gebouwd is. De tweede locatie werd vanuit nautisch oogpunt te ongunstig bevonden zodat de locatie op het eiland overbleef. Uit diverse constructiemethoden voor zowel sluishoofd als sluiskolk werden tien verschillende sluisconstructies gegenereerd waarvan de meest kansrijke globaal werden gedimensioneerd, gecontroleerd op uitvoerbaarheid en stabiliteit en op kostprijs bekeken.Hydraulic EngineeringCivil Engineering and Geoscience
Proceedings of the 3rd Workshop on Multimodal Output Generation
Full text linkvan der Sluis I, Bergmann K, van Hooijdonk C, Theune M. Proceedings of the 3rd Workshop on Multimodal Output Generation. In: MOG 2010. Twente/Enschede, NL: CTIT; 2010
Risk factors for injury in talented soccer and tennis players: A maturation-driven approach
Full text linkTalented athletes having their growth spurt have an increased injury risk Young talented athletes that mature have an increased injury risk. Human movement scientist Alien van der Sluis studied soccer players of the talent development program of FC Groningen and tennis players of the talented development program of the Royal Dutch Lawn Tennis Federation (KNLTB). The soccer players were followed for three years around their adolescent growth spurt. In the year of their growth spurt, players have more injuries compared to the year before or the year after, and they miss more training sessions and matches. A possible cause is the different rates in which bone tissue, muscle tissue and tendon tissue adapt to the growing body. More specific, players that grow more than 0.6 cm in one month, have an increased risk for injury in the next month. Moreover, players with a late growth spurt are relatively small compared to their peers, and this leads to more injuries compared to their ‘earlier mature’ counterparts. Furthermore, tennis players high in risk-taking behavior (typical for puberty), have more injuries and players with better metacognitive skills such as monitoring, have less injuries. Players may be better capable of monitoring small physical complaints, which could help them to prevent themselves from having more severe injuries. Van der Sluis concluded that during puberty, there are specific risk factors for injuries in talented athletes. Coaches and trainers should estimate the moment of the adolescent growth spurt, to take injury preventive measures at the right moment. Monthly monitoring of length, could help to predict an increased risk of injury in periods of intensive growth. At last, it is advised to provide feedback to players high in risk-taking and to educate athletes in monitoring their own training process
Detecting Specific Genotype by Environment Interactions Using Marginal Maximum Likelihood Estimation in the Classical Twin Design
Full text linkConsiderable effort has been devoted to the analysis of genotype by environment (G × E) interactions in various phenotypic domains, such as cognitive abilities and personality. In many studies, environmental variables were observed (measured) variables. In case of an unmeasured environment, van der Sluis et al. (2006) proposed to study heteroscedasticity in the factor model using only MZ twin data. This method is closely related to the Jinks and Fulker (1970) test for G × E, but slightly more powerful. In this paper, we identify four challenges to the investigation of G × E in general, and specifically to the heteroscedasticity approaches of Jinks and Fulker and van der Sluis et al. We propose extensions of these approaches purported to solve these problems. These extensions comprise: (1) including DZ twin data, (2) modeling both A × E and A × C interactions; and (3) extending the univariate approach to a multivariate approach. By means of simulations, we study the power of the univariate method to detect the different G × E interactions in varying situations. In addition, we study how well we could distinguish between A × E, A × C, and C × E. We apply a multivariate version of the extended model to an empirical data set on cognitive abilities
Returns for Entrepreneurs vs. Employees: The Effect of Education and Personal Control on the Relative Performance of Entrepreneurs vs. Wage Employees
Full text linkHow valuable is education for entrepreneurs' performance as compared to employees'? What might explain any differences? And does education affect peoples' occupational choices accordingly? We answer these questions based on a large panel of US labor force participants. We show that education affects peoples' decisions to become an entrepreneur negatively. We show furthermore that entrepreneurs have higher returns to education than employees (in terms of the comparable performance measure 'income'). This is the case even when estimating individual fixed effects of the differential returns to education for spells in entrepreneurship versus wage employment, thereby accounting for selectivity into entrepreneurial positions based on fixed individual characteristics. We find these results irrespective of whether we control for general ability and/or whether we use instrumental variables to cope with the endogenous nature of education in income equations. Finally, we find (indirect) support for the argument that the higher returns to education for entrepreneurs is due to fewer (organizational) constraints faced by entrepreneurs when optimizing the profitable employment of their education. Entrepreneurs have more personal control over the profitable employment of their human capital than wage employees.entrepreneurship, self-employment, returns to education, performance, personal control, locus of control, human capital, wages, incomes
MetaSWAP_V7_2_0. Rapportage van activiteiten ten behoeve van certificering met Status A
No full textVeel vragen over het waterbeheer betreffen situaties en processen die worden beïnvloed door hydrologische terugkoppelingen op regionale en zelfs nationale schaal. MetaSWAP is bedoeld voor het vervangen van SWAP bij het grootschalig doorrekenen van bodem-plant-atmosfeerkolommen die gekoppeld zijn aan geïntegreerde gebiedsmodellen van grond- en oppervlaktewater. MetaSWAP is een ‘meta’-model van SWAP. Het metaconcept is gebaseerd op een vereenvoudigde oplossing van de niet-lineaire partiële differentiaalvergelijking om bodemfysische processen te beschrijven, de zogenaamde Richards-vergelijking. Deze vergelijking wordt vervangen door twee ‘gewone’ differentiaalvergelijkingen, één voor de procesbeschrijving, en één voor de waterbalans. Om het informatieverlies dat bij die vereenvoudiging optreedt te compenseren, is het nodig om MetaSWAP te kalibreren en te valideren op SWAP. Dit document beschrijft hoe dat gedaan wordt, en tevens hoe de kwaliteit van het model is geborgd volgens de zogenaamde ‘Status A’ standaard van de WOT Natuur & Milieu
The effects of hyperosmosis or high pH on a dual-species biofilm of Enterococcus faecalis and Pseudomonas aeruginosa: an in vitro study
No full textvan der Waal SV, van der Sluis LWM, Ozok AR, Exterkate RAM, van Marle J, Wesselink PR, de Soet JJ. The effects of hyperosmosis or high pH on a dual-species biofilm of Enterococcus faecalis and Pseudomonas aeruginosa: an in vitro study. International Endodontic Journal, 44, 11101117, 2011. Aim To investigate the effect of hyperosmotic hyperosmosis or alkaline stress on a dual-species biofilm of Enterococcus faecalis and Pseudomonas aeruginosa. Methodology Biofilms were grown on glass cover slips suspended in bacterial inoculate for 96 h, after which the cover slips with attached biofilms were immersed in brain heart infusion broth (BHI-broth) with 6 mol L(-1) sodium chloride (NaCl) representing the hyperosmotic group or Ca(OH)2, pH 12.1, representing the alkaline group. Two per cent sodium hypochlorite and BHI- broth served as positive and negative controls, respectively. After treatment, the biofilms were washed, harvested and plated on blood-agar plates after serial dilution. The bactericidal effect was assessed by determining the colony-forming units (CFU). The effect on the biofilm mass was imaged with confocal laser scanning microscopy (CLSM). Results Hyperosmosis reduced the CFU of both species significantly after 72 h (P < 0.0001). After 168 h, P.aeruginosa was eradicated and the E.faecalis reduction was more than 99%. High pH could not induce a significant bacterial reduction. CLSM revealed dense flocculation of the biofilms incubated in alkaline broth. Conclusion Hyperosmosis effectively reduced a dual-species biofilm of E.faecalis and P.aeruginosa, whilst high pH had limited bactericidal effect in this mode
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