1,732 research outputs found
RAGE and the innate immune response in infection and inflammation
No full textDe receptor RAGE (receptor for advanced glycation end products) is betrokken bij de immuunrespons, bijvoorbeeld door de migratie van ontstekingscellen naar de plek van de ontsteking te bevorderen of pro-inflammatoire processen te stimuleren. Marieke van Zoelen richt zich op RAGE als mogelijk therapeutisch aangrijpingspunt
Severe sepsis and septic shock [author's reply]
No full textTo the Editor: We would like to address two potentially confusing issues concerning venous oxygen saturation (Svo(2)) as presented in Table 1 of the review by Angus and van der Poll (Aug. 29 issue).(1) First, Table 1 suggests that Svo(2) is raised in sepsis, severe sepsis, and septic shock. Depending on the timing of patient presentation and the type of sepsis and septic shock, Svo(2) may indeed be elevated as a result of microcirculatory shunting or mitochondrial dysfunction. However, in septic shock, Svo(2) can be depressed, reflecting an increase in the extraction of oxygen du
Kinome activity profiling and kinase modulation of pulmonary inflammation
No full textOndanks de hoge standaard van de moderne gezondheidszorg, blijven infectieuze ziekten een niet te onderschatten gevaar voor de gezondheid. Vaak wordt de long getroffen door dergelijke infecties. Hoewel de ontstekingsreactie onmisbaar is voor de immuunreactie, kan hyper-inflammatie schadelijk zijn. Hiermee moet rekening worden gehouden. Kinasen (een groep enzymen) zijn betrokken bij het signaleren van ontstekingen. Arjan Hoogendijk keek naar de werking van kinasen in experimentele longontstekingen veroorzaakt door veel voorkomende ziekteverwekkers. Hij constateert dat er met succes kan worden ingegrepen op het beloop van de ontstekingsreactie
Correction: Increased von willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis (PLoS Negl Trop Dis 11(3), e0005468, 10.1371/journal.pntd.0005468 PMID: 28296884)
No full textThere is an error in the article XML causing the eighth author’s name to be indexed incorrectly. The name should be indexed as van der Poll T
Sepsis in the intensive care unit: epidemiology, outcome and host response
No full textSepsis is a life-threatening syndrome that arises when a dysbalanced patient response to an infection causes damage to the body’s own organs and tissues. Sepsis is, to date, still a major cause of morbidity and mortality worldwide. A detailed understanding of the pathogenesis of sepsis is likely to aid future individualized sepsis treatment. Early detection of causative pathogens and the development of new molecular techniques for early prognostication can be essential in individualized care for, and treatment of, patients with sepsis. In patients with sepsis, multiple risk factors for unfavorable outcome have been suggested, such as age, gender, premorbid conditions, acute disease conditions and the increased susceptibility to nosocomial infections. In this thesis, we studied the relationship of these host factors with disease severity, host response and outcome. We found that gender and premorbid diabetes were not associated with alterations in the host response, disease severity or outcome in critically ill sepsis patients. However, factors that were of influence included advanced age, dysregulated glucose levels and thrombocytopenia. In addition to this, ICU-acquired infections did not occur more often in patient admitted with sepsis and bear an overall low attributable mortality. The studies described in this thesis are unique in that they integrated detailed clinical and microbiological data with comprehensive host response measurements in one of the largest sepsis cohorts in the world, the MARS cohort
Diabetes and sepsis outcomes - it is not all bad news
No full textPatients with diabetes mellitus have an increased risk of developing infections and sepsis. In this issue of Critical Care Esper and colleagues report on a large survey, involving 12.5 million sepsis cases, that examined the impact of pre-existing diabetes on organ dysfunction during sepsis. Their main conclusion was that diabetes patients, relative to non-diabetics, were less likely to develop respiratory failure and more likely to develop renal failure during the course of sepsi
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