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GWAS Summary Data of: Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality
No full textData related to this article:Nat Genet. 2016 Dec;48(12):1557-1563. doi: 10.1038/ng.3708. Epub 2016 Oct 31.Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.Eppinga RN1, Hagemeijer Y1, Burgess S2, Hinds DA3, Stefansson K4,5, Gudbjartsson DF4,6, van Veldhuisen DJ1, Munroe PB7,8, Verweij N1, van der Harst P1,9,10.Author informationAbstractResting heart rate is a heritable trait correlated with life span. Little is known about the genetic contribution to resting heart rate and its relationship with mortality. We performed a genome-wide association discovery and replication analysis starting with 19.9 million genetic variants and studying up to 265,046 individuals to identify 64 loci associated with resting heart rate (P < 5 × 10-8); 46 of these were novel. We then used the genetic variants identified to study the association between resting heart rate and all-cause mortality. We observed that a genetically predicted resting heart rate increase of 5 beats per minute was associated with a 20% increase in mortality risk (hazard ratio 1.20, 95% confidence interval 1.11-1.28, P = 8.20 × 10-7) translating to a reduction in life expectancy of 2.9 years for males and 2.6 years for females. Our findings provide evidence for shared genetic predictors of resting heart rate and all-cause mortality.PMID: 27798624DOI: 10.1038/ng.3708 [Indexed for MEDLINE]THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
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