762 research outputs found
Exploiting semantics for constructing and comparing occupational and educational-driven qualifications: the TIPTOE project
No full textIn recent years, mobility of students and workers started to be considered as a way for answering skill shortages in the European labor world. However, in order to implement effective mobility practices, suitable instruments supporting transparency and readability of the outcomes of learning processes as well as of the needs of companies and employers in general have to be developed. In fact, though some instruments have been introduced (like, for instance, the European Qualification Framework, EQF, the European Credit system for Vocational Education and Training, ECVET, etc.), they are often seen as theoretical tools rather than a practical help for involved stakeholders. In this work, the results of the TIPTOE project, a transnational initiative funded by the European Commission under the Lifelong Learning Programme are illustrated. In particular, the semantic-based methodology for the construction of a European-wide profile mixing education and labor worlds perspectives in the trade sector is discussed. Furthermore, a number of tools allowing end-users to compare owned qualifications to the reference one and supporting stakeholders in the reading of national educational and occupational profiles in the EQF dimension are presente
Tasks, cognitive agents, and KB-DSS in workflow and process management
No full textThe purpose of this paper is to propose a nonparametric interest rate term structure model and investigate its implications on term structure dynamics and prices of interest rate derivative securities. The nonparametric spot interest rate process is estimated from the observed short-term interest rates following a robust estimation procedure and the market price of interest rate risk is estimated as implied from the historical term structure data. That is, instead of imposing a priori restrictions on the model, data are allowed to speak for themselves, and at the same time the model retains a parsimonious structure and the computational tractability. The model is implemented using historical Canadian interest rate term structure data. The parametric models with closed form solutions for bond and bond option prices, namely the Vasicek (1977) and CIR (1985) models, are also estimated for comparison purpose. The empirical results not only provide strong evidence that the traditional spot interest rate models and market prices of interest rate risk are severely misspecified but also suggest that different model specifications have significant impact on term structure dynamics and prices of interest rate derivative securities.
Tasks, cognitive agents, and KB-DSS in workflow and process management
No full textThe purpose of this paper is to propose a nonparametric interest rate term structure model and investigate its implications on term structure dynamics and prices of interest rate derivative securities. The nonparametric spot interest rate process is estimated from the observed short-term interest rates following a robust estimation procedure and the market price of interest rate risk is estimated as implied from the historical term structure data. That is, instead of imposing a priori restrictions on the model, data are allowed to speak for themselves, and at the same time the model retains a parsimonious structure and the computational tractability. The model is implemented using historical Canadian interest rate term structure data. The parametric models with closed form solutions for bond and bond option prices, namely the Vasicek (1977) and CIR (1985) models, are also estimated for comparison purpose. The empirical results not only provide strong evidence that the traditional spot interest rate models and market prices of interest rate risk are severely misspecified but also suggest that different model specifications have significant impact on term structure dynamics and prices of interest rate derivative securities.
The SEC-system : reuse support for scheduling system development
No full textRecently, in a joint cooperation of Stichting VNA, SAL Apotheken, the Faculty of Management and Organization, and the University Centre for Pharmacy, University of Groningen in the Netherlands, a Ph.D-study started regarding Apot(he)ek, Organization and Management (APOM). The APOM-project deals with the structuring and steering of pharmacy organization. The manageability of the internal pharmacy organization, and the manageability of the direct environment of pharmacy organization is the subject matter. The theoretical background of the APOM-project is described. A literature study was made to find mixes of objectives. Three mixes of objectives in pharmacy organization are postulated; the product mix, the process mix, and the customer mix. The typology will be used as a basic starting point for the empirical study in the next phase of the APOM-project.
A novel taxonomic marker that discriminates between morphologically complex actinomycetes
No full textIn the era when large whole genome bacterial datasets are generated routinely, rapid and accurate molecular systematics is becoming increasingly important. However, 16S ribosomal RNA sequencing does not always offer sufficient resolution to discriminate between closely related genera. The SsgA-like proteins are developmental regulatory proteins in sporulating actinomycetes, whereby SsgB actively recruits FtsZ during sporulation-specific cell division. Here, we present a novel method to classify actinomycetes, based on the extraordinary way the SsgA and SsgB proteins are conserved. The almost complete conservation of the SsgB amino acid (aa) sequence between members of the same genus and its high divergence between even closely related genera provides high-quality data for the classification of morphologically complex actinomycetes. Our analysis validates Kitasatospora as a sister genus to Streptomyces in the family Streptomycetaceae and suggests that Micromonospora, Salinispora and Verrucosispora may represent different clades of the same genus. It is also apparent that the aa sequence of SsgA is an accurate determinant for the ability of streptomycetes to produce submerged spores, dividing the phylogenetic tree of streptomycetes into liquid-culture sporulation and no liquid-culture sporulation branches. A new phylogenetic tree of industrially relevant actinomycetes is presented and compared with that based on 16S rRNA sequences
Cortical mechanisms underlying low-level motion processing in the visual system of human and non-human primates
No full textChoosing Attribute Weights for Item Dissimilarity using Clikstream Data with an Application to a Product Catalog Map
No full textIn content- and knowledge-based recommender systems often a measure of (dis)similarity between items is used. Frequently, this measure is based on the attributes of the items. However, which attributes are important for the users of the system remains an important question to answer. In this paper, we present an approach to determine attribute weights in a dissimilarity measure using clickstream data of an e-commerce website. Counted is how many times products are sold and based on this a Poisson regression model is estimated. Estimates of this model are then used to determine the attribute weights in the dissimilarity measure. We show an application of this approach on a product catalog of MP3 players provided by Compare Group, owner of the Dutch price comparison site http://www.vergelijk.nl, and show how the dissimilarity measure can be used to improve 2D product catalog visualizations.dissimilarity measure;attribute weights;clickstream data;comparison
Unlocking Streptomyces spp. for use as sustainable industrial production platforms by morphological engineering
No full textFilamentous actinomycetes are commercially widely used as producers of natural products (in particular antibiotics) and of industrial enzymes. However, the mycelial lifestyle of actinomycetes, resulting in highly viscous broths and unfavorable pellet formation, has been a major bottleneck in their commercialization. Here we describe the successful morphological engineering of industrially important streptomycetes through controlled expression of the morphogene ssgA. This led to improved growth of many industrial and reference streptomycetes, with fragmentation of the mycelial clumps resulting in significantly enhanced growth rates in batch fermentations of Streptomyces coelicolor and Streptomyces lividans. Product formation was also stimulated, with a twofold increase in yield of enzyme production by S. lividans. We anticipate that the use of the presented methodology will make actinomycetes significantly more attractive as industrial and sustainable production hosts. Copyright © 2006, American Society for Microbiology. All Rights Reserved. Chemicals / CAS: Bacterial Proteins; Culture Media; ssgA protein, bacteria
Measurement errors in GDP and forward-looking monetary policy: The Swiss case
No full textThis paper analyzes forward-looking rules for Swiss monetary policy in a small structural VAR consisting of four variables. First, the paper looks at the ex ante inflation-output-growth volatility trade-off for a forward-looking policy aiming at a convex combination of a strict inflation and output growth targeting rule implied by this SVAR model. Thereby the paper introduces a new analytical method. Second, the paper considers the effect of measurement errors in GDP on this inflation-output-growth volatility trade-off. Third, the paper works at the impact of changing beliefs about the potential growth rate on the variability of output growth and inflation. Finally the effects of different targets in a forward-looking monetary policy on ex post or unconditional volatility of inflation and output growth is explored by a simulation exercise. --Structural VAR,forward-looking monetary policy,efficiency frontier,GDP measurement errors
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