130 research outputs found
Verkenning naar de wenselijkheid en mogelijkheid van selectie op geschiktheid voor het beroep van leraar en van verzwaring van vakinhoudelijke eisen voor de tweedegraads lerarenopleidingen: eindrapportage
No full textVerkenning naar de wenselijkheid en mogelijkheid van selectie op geschiktheid voor het beroep van leraar en van verzwaring van vakinhoudelijke eisen voor de tweedegraads lerarenopleidingen. Het rapport 'wenselijkheid en mogelijkheid van selectie op geschiktheid voor het beroep van leraar', is door het ministerie van OCW gebruikt als input voor de voortgangsrapportage voor de Lerarenagenda 2013-2020. Dit rapport is het resultaat van een verkennend onderzoek dat is uitgevoerd door het kenniscentrum Onderwijs en Opvoeding van de HvA in samenwerking met het ICLON, en dat onder leiding stond van Marco Snoek en Jan van Driel. Op basis van de focusgesprekken constateren de onderzoekers dat veel opleidingen meer mogelijkheden wensen ten aanzien van selectie voor de poort. Niet in alle gevallen ligt daarbij echter de focus op selectie t.a.v. geschiktheid. Bovendien hebben met name de HBO-opleidingen nu reeds diverse maatregelen genomen binnen de huidige regelgeving (zoals de studiekeuzecheck en propedeuse-eisen). Het lijkt verstandig om de effecten van deze en andere maatregelen nader te evalueren alvorens tot een brede instroomselectie over te gaan. Terughoudendheid ten aanzien van grootschalige maatregelen lijkt op zijn plaats. Pilots op kleine schaal kunnen meer zicht geven op mogelijke instrumenten die ingezet kunnen worden en hun effecten op de instroom. De lerarenopleidingen lijken bereid om met dergelijke pilots te experimenteren. In opdracht van NRO is nu een vervolgonderzoek gestart in de vorm van een literatuur review rond de mogelijkheden en voorspelbaarheid van selectie van leraren ten aanzien van hun geschiktheid voor het beroep
Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall
No full textBackground and aimsHaplogroup I – a common European paternal lineage of the Y chromosome is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroups on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance. MethodsWe examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n=1,217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n=393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men.ResultsA majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men. ConclusionsOur data show that genetic variation on the Y chromosome is not associated with histological characteristics of the the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin. <br/
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
No full textCorrection to "The power of genetic diversity in genome-wide association studies of lipids
The Genome of the Netherlands: design, and project goals
No full textWithin the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the European BBMRI. One of the aims of BBMRI-NL is to enrich biobanks with different types of molecular and phenotype data. Here, we describe the Genome of the Netherlands (GoNL), one of the projects within BBMRI-NL. GoNL is a whole-genome-sequencing project in a representative sample consisting of 250 trio-families from all provinces in the Netherlands, which aims to characterize DNA sequence variation in the Dutch population. The parent-offspring trios include adult individuals ranging in age from 19 to 87 years (mean = 53 years; SD = 16 years) from birth cohorts 1910-1994. Sequencing was done on blood-derived DNA from uncultured cells and accomplished coverage was 14-15x. The family-based design represents a unique resource to assess the frequency of regional variants, accurately reconstruct haplotypes by family-based phasing, characterize short indels and complex structural variants, and establish the rate of de novo mutational events. GoNL will also serve as a reference panel for imputation in the available genome-wide association studies in Dutch and other cohorts to refine association signals and uncover population-specific variants. GoNL will create a catalog of human genetic variation in this sample that is uniquely characterized with respect to micro-geographic location and a wide range of phenotypes. The resource will be made available to the research and medical community to guide the interpretation of sequencing projects. The present paper summarizes the global characteristics of the project
Additional file 25 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
No full text<b>External Organisations</b><br/>Queen Mary University of London; University of Michigan; Boston University; National University of Defense Technology; King's College Hospital NHS Foundation Trust; University of Pennsylvania; University of Central Florida; Stanford University; Pennsylvania State University; Affiliated Hospital of Nantong University; Boston Children's Hospital; University of Regensburg; Washington University St. Louis; Harvard University; Guizhou Provincial People’s Hospital; deCODE Genetics (Iceland); University of Iceland; Landspitali University Hospital; Korea National Institute of Health; RIKEN; Osaka University; Broad Institute; Massachusetts General Hospital; Chinese Academy of Medical Sciences; Sichuan University; Peking University; Mayo Clinic Jacksonville, FL; St Olav's University Hospital; University of Bristol; University of Helsinki; Northwestern Polytechnical University Xian; University of Washington; Cincinnati Children's Hospital Medical Center; 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Peloso (Creator)Additional file 25: Table S16. Comparison of effect size estimates for sex-stratified analysis in the replication cohorts
The power of genetic diversity in genome-wide association studies of lipids (Author Correction: vol 600, pg 675, 2021)
No full textNegative selection in humans and fruit flies involves synergistic epistasis
No full textOngoing selection against rare protein-disrupting mutations depends on an individual’s relative decline in fitness with each additional mutation.</jats:p
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene
No full text- …
