629 research outputs found
Some additional Notes on external Features and on the jaw muscles of Orthragoriscus mola (L.)
No full textIn 1939 J. M. van Roon and J. J. ter Pelkwijk published some data on two specimens of Orthragoriscus mola (L.) stranded on the Dutch coast.
Measurements of bones and muscles of the jaw were given on account of the functional treatise concerning the mechanism of the jaw of Orthragoriscus given by Van Dobben (1935), based upon one specimen that differed in many ways from both individuals we dissected.
In the following years, we got three more specimens and an examination of the jaw muscles proved them to be fully agreeing with the two fishes described before. It seems worth while to publish corresponding data and measurements.
Specimen C, a female, stranded December 12, 1939 near Kamperduin in the neighbourhood of Schoorl. This fish was more oblong than either of the others. The sides were covered with longitudinal ripples. J. J. ter Pelkwijk dissected it on the beach on December 13.
Specimen D, a male caught in a trawl near the coast off Scheveningen December 13, 1940, was brought to the Zoological Garden at The Hague where it was exhibited for a month in a 4 % formol solution. Then it was brought to the Rijksmuseum van Natuurlijke Historie at Leiden, were it was dissected by J. M. van Roon and P. H. Creutzberg. This fish was much smaller than the others and more circular. It had a conspicuous ridge above the eyes and a curved ridge under the eyes and pectoral fins.
Specimen E, a female, stranded November 30, 1941 near Schoorl; it was found by Mr. K. Kuiper at Alkmaar, who sent it to the Rijksmuseum van Natuurlijke Historie, where it was dissected by J. M. van Roon and G. P.
Baerends on December 11. This fish differed less than C and D fro
Characterizing properties of approximate solutions for optimization problems
No full textoptimization
FRI0426 Response of the reactive species interactome to hypothermia induced raynaud’s attack in primary raynaud and systemic sclerosis
No full textBackground: Although the exact etiology of systemic sclerosis (SSc) remains unknown, a current hypothesis is that reactive species (including reactive oxygen species (ROS), reactive nitrogen species (RNS and reactive sulfur species (RSS)) play an important role in the pathogenesis. In addition, the chemical interactions between these molecules, also known as the reactive species interactome, may lead to the formation of more harmful free radicals, thus leading to more damage. We have previously shown a rapid free thiol increase in SSc patients during a cooling and recovery experiment, however the implications of RNS and RSS in this process remain uncharacterized.
Objectives: The aim of the current study was to explore nitric oxide and sulfate response, as a measure of the unified reactive species interactome, during hypothermia induced Raynaud’s attack in systemic sclerosis (SSc), primary Raynaud’s phenomenon (PRP) and healthy controls (HC).
Methods: Healthy controls (n=10), PRP patients (n=10) and SSc patients (n=10), all aged ≥18 years, were included. All SSc patients fulfilled the ACR/EULAR 2013 criteria. Fingertip photoelectric plethysmography was performed during a standardised cooling and recovery experiment. Patient characteristics were obtained and blood was drawn at four predetermined time points (T0, T1, T2 and T3). In addition to the previously mentioned free thiols, the following markers were also measured: nitros(yl)ated species, nitrite, nitrate, sulfate and the vascular leakage related molecules angiopoietin-1 and angiopoietin-2).
Results: Our results revealed a significantly longer median duration of hypoperfusion and longer recovery time in SSc patients compared to PRP patients and HC. This coincided with stable levels of angiopoietin-1/angiopoietin-2 throughout the experiment. In regards to the thiol modification related molecules, (nitrate, nitrite and RXNO) an increased median level of nitrate (T2: median 29.6 µmol, range 21.99–41.70 µmol, p=0.041) was found in SSc patients. Correspondingly, the same trend was observed for the median plasma concentrations of sulfate (p>0.05 at all time points)
Statistical method for modeling sequencing data from different technologies in longitudinal studies with application to Huntington disease
No full textAdvancement of gene expression measurements in longitudinal studies enables the identification of genes associated with disease severity over time. However, problems arise when the technology used to measure gene expression differs between time points. Observed differences between the results obtained at different time points can be caused by technical differences. Modeling the two measurements jointly over time might provide insight into the causes of these different results. Our work is motivated by a study of gene expression data of blood samples from Huntington disease patients, which were obtained using two different sequencing technologies. At time point 1, DeepSAGE technology was used to measure the gene expression, with a subsample also measured using RNA-Seq technology. At time point 2, all samples were measured using RNA-Seq technology. Significant associations between gene expression measured by DeepSAGE and disease severity using data from the first time point could not be replicated by the RNA-Seq data from the second time point. We modeled the relationship between the two sequencing technologies using the data from the overlapping samples. We used linear mixed models with either DeepSAGE or RNA-Seq measurements as the dependent variable and disease severity as the independent variable. In conclusion, (1) for one out of 14 genes, the initial significant result could be replicated with both technologies using data from both time points; (2) statistical efficiency is lost due to disagreement between the two technologies, measurement error when predicting gene expressions, and the need to include additional parameters to account for possible differences
Adriaen Koerbagh, Nieuw Woorden-boek der Regten 1664
No full textDiplomatische transcriptie van de uitgave:
’t NIEUW WOORDEN-BOEK Der REGTEN, Ofte een Vertaalinge en Uytlegginge Van Meest alle de Latijnse woorden, en wijse van spreeken, in alle Regten en Regts-geleerders Boeken en Schriften gebruykelijk: Ten deele uyt de Schriften van de Heeren H. en W. de GROOT, en andere versamelt en by een gestelt, Ende Ten deele nu eerst uyt het Latijn in ’t Neder-duyts tot dienst en nut van alle Practisijns en Liefhebbers overgeset; Door Mr. A. K. t’AMSTELREDAM, By de Weduwe van Jan Hendriksz Boom, Zalr. Boekverkoopster, op de Cingel, by Ian-Roon-Poorts-Toorn, in de Boek-binder, 1664
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