1,720,986 research outputs found

    CDx_Supplementary_Information_WH_version2_11MAY2018 – Supplemental material for Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial

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    Supplemental material, CDx_Supplementary_Information_WH_version2_11MAY2018 for Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial by Adriaan Tuiten, Frits Michiels, Koen BE Böcker, Daniël Höhle, Jack van Honk, Robert PJ de Lange, Kim van Rooij, Rob Kessels, Jos Bloemers, Jeroen Gerritsen, Paddy Janssen, Leo de Leede, John-Jules Meyer, Walter Everaerd, Henderik W Frijlink, Hans PF Koppeschaar, Berend Olivier and James G Pfaus in Women’s Health</p

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    Hepatic Radioembolization in Neuroendocrine Neoplasms

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    Neuroendocrine Neoplasms (NEN) is a generic term for a class of rare tumours, consisting of an array of many different tumor types. Similar to the trends noticed internationally, in the Dutch population the incidence of gastro-intestinal pancreatic NEN has increased from 298 per 100.000 per year in 2000 to 828 per 100.000 per year in 2016, according to the Dutch Cancer Registry. On the one hand, the disease has gotten more attention in the last decades and on the other hand more and more accurate diagnostic modalities have become available to detect the disease. Unfortunately at time of diagnosis, 21% of grade 1 NET, 30% of grade 2 NET and 50% of grade 3 NET or NEC show disseminated disease, of which the liver is the most common affected site. Once a NEN patient is diagnosed with liver metastasis, only about 20-30% are eligible for surgical resection with curative intent. Ineligibility for surgery is mainly caused by bilobar involvement of the liver. Additionally, patients with liver metastases of functioning (hormone-producing) NEN suffer of debilitating complaints, like frequent diarrhea and flushing, with a direct impact on quality of life. This emphasizes the clinical need for new therapeutic approaches of NEN liver disease. Radioembolization is a well-established liver-directed treatment for patients suffering from hepatic malignancies. The thesis ‘Hepatic Radioembolization in Neuroendocrine Neoplasms’ will discuss current status and future directions of the treatment in patients suffering for neuroendocrine liver metastases. Besides the promising body of clinical data, the other side of the radioembolization procedure needs to be emphasized, namely its many rapid technical developments in nuclear medicine imaging and the interventional radiology, e.g. angiography suite. Compared to other malignancies, NEN are relatively rare, thus literature on radioembolization in NEN is sparse. The conducted meta-analysis on all available literature reported very promising results on objective response rates and median overall survival. However proper data on patient characteristics and its correlations to treatment outcome were lacking. An additional retrospective study was performed, in an attempt to addresses these gaps in available literature. As most NEN patients suffer from both intra- and extrahepatic disease, it was hypothesized that combining a systemic treatment with an liver directed treatment might be beneficial. The protocol of first prospective trial (HEPAR PLUS) on the combination of PRRT with 177Lu-DOTATATE with 166Ho radioembolization and its preliminary results are discussed. The thesis elaborates on new indications for radioembolization in an upfront, curative setting, instead of the common salvage setting where it currently resides. Based on available literature, radioembolization could have several benefits in pre-operative, pre-ablative or pre-transplantation patients. Furthermore, the thesis reports on several important technical developments in the field of radioembolization; The safety of a small amount of 166Ho microspheres as a treatment simulation prior to the actual radioembolization procedure, as an improved alternative to the current standard, and, aspects and challenges of SPECT/CT imaging with both 166Ho and 99mTc (a.k.a. dual isotope imaging) for future semi-automated patient individualized dosimetry

    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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