239 research outputs found
Sector firm and management performance in The Netherlands : the role of national governance and institutions
No full textPaper presented to the fourth EMOT-workshop, theme 1, Economic performance outco- 1 mes in Europe, Berlin, January 30-February 1, 1997 This paper discusses performance characteristics and differences at three levels: at sector, firm and top management level. First, it explores the extent to which the particularities of the Dutch business system history influence the economic performance of different types of firms and sectors in the Netherlands. Elaborating on earlier work on the Dutch business system (Iterson and Olie, 1992; van Dijk and Punch, 1993: Sorge and Iterson, 1995, Iterson, 1997), it will be hypothesised which sectors and types of firms will prosper in the socio-institutional context and which sectors and types of firms will not. For instance, it will be brought forward that the agricultural sector, the mineral fuels and chemicals sector, the foods and detergents sector, the transport and transshipment sector and the financial services sector have emerged in a favourable socio-institutional context whereas the steel and the car sector have not. As to different types of firms, it will be brought forward that family-owned and state-owned companies are much less dominant in the Netherlands than public limited liability companies. At firm level, special attention will be given to the large multinational corporations, such as the Royal Dutch Shell Group, Unilever, AKZO, DSM and Philips. Secondly, the socially constructed managerial capabilities and discretion - again, related to economic performance - will be explored in this paper. They are to be understood as an outcome of the idiosyncratic formation of social groups in the Netherlands and the related emergent governance principles (Cf. Kristensen, 1995), which is known as `pillarisation''.management and organization theory ;
Functional heterogeneity of oxygen supply with blood and hemoglobin-based oxygen carriers in porcine models of hemorrhagic shock
No full textOp hemoglobine gebaseerde zuurstofdragers (HBOC’s) kunnen een alternatief zijn voor het toedienen van bloed bij ernstige bloedingen. Ze leveren niet alleen volume en zuurstof, maar zijn ook direct of indirect van invloed op de spanning in bloedvaten. Mat van Iterson onderzocht bij varkens de effecten van verschillende HBOC’s op de zuurstofvoorziening naar het hart en de darmen na een gecontroleerde bloeding. HBOC’s zijn effectief in het transporteren van zuurstof naar de microcirculatie (de kleinste vaten), maar door het samenknijpen van bloedvaten wordt een tekort aan bloedvolume gemaskeerd. Om de effectiviteit van HBOC’s vast te stellen, is het beoordelen van de microcirculatie daarom een voorwaarde
Functional heterogeneity of oxygen supply with blood and hemoglobin-based oxygen carriers in porcine models of hemorrhagic shock
No full textOp hemoglobine gebaseerde zuurstofdragers (HBOC’s) kunnen een alternatief zijn voor het toedienen van bloed bij ernstige bloedingen. Ze leveren niet alleen volume en zuurstof, maar zijn ook direct of indirect van invloed op de spanning in bloedvaten. Mat van Iterson onderzocht bij varkens de effecten van verschillende HBOC’s op de zuurstofvoorziening naar het hart en de darmen na een gecontroleerde bloeding. HBOC’s zijn effectief in het transporteren van zuurstof naar de microcirculatie (de kleinste vaten), maar door het samenknijpen van bloedvaten wordt een tekort aan bloedvolume gemaskeerd. Om de effectiviteit van HBOC’s vast te stellen, is het beoordelen van de microcirculatie daarom een voorwaarde
Société d'Histoire du Droit des pays flamands, picards et wallons. Compte rendu des journées tenues à Liège du 20 au 23 Mars 1932
No full textPiétresson de Saint-Aubin P., Dubois Léonce, Wagon M., Van Iterson M.W., Lepointe Gabriel, Ganshof Ferdinand-Louis, Lévy-Bruhl Henri, Turpin P., Decroix Marcel, Fairon E., Espinas Georges, Harsin Paul, Poncelet Edouard, Laurent H. Société d'Histoire du Droit des pays flamands, picards et wallons. Compte rendu des journées tenues à Liège du 20 au 23 Mars 1932. In: Revue du Nord, tome 18, n°71, août 1932. pp. 187-210
The power of high-dimensional data in genomics research
No full textIn this thesis novel statistical methods that help scientists extract maximal information from high-dimensional data, in particular those derived by transcriptomics, are presented.This study was supported by a grant from the Centre for Medical Systems Biology within the framework of the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO). This work is part of the BioRange bioinformatics research program supported by the Netherlands Bioinformatics Centre (NBIC).UBL - phd migration 201
Life Expectancy of Daily Newspapers in the Netherlands: The Period 1848 - 1997.
No full textIn 1848 freedom of press was written into the Constitution of the Kingdom of the Netherlands. This paper investigates the expected life span of daily newspapers in the Netherlands since then. Life expectancy depends on the cyclical evolution of the number of daily newspapers through time. The life cycle of the competitive newspaper industry in the Netherlands is characterized by a turning period of turmoil during World War II. Models that aim at estimating the expected lifetime of newspaper that do not acknowledge the cyclical characteristics of the industry are most likely misspecified.Economics ;
The effects of liquefying place, time, and organizational boundaries on employee behavior: Lessons of classical sociology
No full textThis paper explores how the liquefying of place, time, and organizational boundaries affects social control and self-regulation at the workplace. We address Norbert Elias's civilizing process theory (Elias 2000), and some of the criticism it has evoked, to explore the effects of both physical proximity and distance on control and behavior in work organizations. We hold that the theory still has relevance for contemporary organization and management theory with roots in the more classical traditions of the sociological discipline. Assuming that physical proximity at work is decreasing because of increased telework, the geographical spread of firms, and growing interorganizational collaboration, there is much to be gained by maintaining classical perspectives. © 2013 M@n@gement and the author(s)
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
No full textTrait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium. We detected cis-eQTL for 88% of genes, and these were replicable in numerous tissues. Distal trans-eQTL (detected for 37% of 10,317 trait-associated variants tested) showed lower replication rates, partially due to low replication power and confounding by cell type composition. However, replication analyses in single-cell RNA-seq data prioritized intracellular trans-eQTL. Trans-eQTL exerted their effects via several mechanisms, primarily through regulation by transcription factors. Expression of 13% of the genes correlated with polygenic scores for 1,263 phenotypes, pinpointing potential drivers for those traits. In summary, this work represents a large eQTL resource, and its results serve as a starting point for in-depth interpretation of complex phenotypes.Analyses of expression profiles from whole blood of 31,684 individuals identify cis-expression quantitative trait loci (eQTL) effects for 88% of genes and trans-eQTL effects for 37% of trait-associated variants.Stress-related psychiatric disorders across the life spa
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