1,721,088 research outputs found
De evaluatie van nieuwe biomerkers in Gynaecologische Tumoren. De opkomende rol van Proteomics
No full textThe objective of this research project was to validate newly discovered biomarkers and to discover new biomarkers by using proteomics in serum or plasma of ovarian and cervical tumours.The first diagnostic problem was the differentiation between a benign and a malignant ovarian mass. Even when a pelvic mass is present, it is difficult to discriminate between benign and malignant disease. In a first study the ROMA algorithm, a combination of CA125 and HE4, was validated and compared to the gold standard CA125. In this large study we were able to demonstrate that neither HE4, nor the ROMA increased the detection of malignant disease.However, the differentiation of benign and malignant masses is not purely based on tumour markers alone. This is why a second study was performed, in which the diagnostic accuracy of ROMA was assessed and compared to the two most widely used ultrasound methods, the risk of malignancy index (RMI) and subjective assessment by ultrasound. Subjective assessment had the highest AUC (0.968), followed by the RMI (0.931) and the ROMA (0.893). Based on these results we concluded that ultrasound, especially subjective assessment by ultrasound, remains superior in discriminating malignant from benign ovarian masses. In an exploratory study we investigated whether endorepellin, an angiostatic peptide, could be used as a tumour marker for the differentiation between benign and malignant ovarian masses. This international cohort study was conducted in Belgium, Czech Republic, Sweden, and Italy. In postmenopausal women, all best performing panels included endorepellin with the highest AUC (0.920) for the triple combination of CA125, HE4 and endorepellin. Endorepellin also performed well in stage I and LMP tumours. These results need to be validated. Currently, the triple combination model is being validated in an independent study. The second diagnostic problem is the diagnosis of positive lymph nodes in cervical cancer. Lymph node involvement is a strong prognostic factor for cervical cancer. There is a strong need for biomarkers that predict lymph node involvement in cervical cancer. After depletion and SELDITOF MS analysis we were able to predict lymph node involvement with an AUC of 0.95. However, the attempts to identify the proteins behind the differentially expressed peaks were unsuccessful. Finally, the literature was critically reviewed and commented. It can be noticed that, although a lot of efforts have been put into global proteomics, none of the efforts have paid off. To date proteomic studies have not been able to change clinical practice.status: Publishe
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Quality of surgery and treatment and its association with hospital volume: A population-based study in more than 5000 Belgian ovarian cancer patients.
Full text linkpeer reviewed[en] BACKGROUND: Different sets of quality indicators are used to identify areas for improvement in ovarian cancer care. This study reports transparently on how (surgical) indicators were measured and on the association between hospital volume and indicator results in Belgium, a country setting without any centralisation of ovarian cancer care.
METHODS: From the population-based Belgian Cancer Registry, patients with a borderline malignant or invasive epithelial ovarian tumour diagnosed between 2014 and 2018 were selected and linked to health insurance and vital status data (n = 5119). Thirteen quality indicators on diagnosis and treatment were assessed and the association with hospital volume was analysed using logistic regression adjusted for case-mix.
RESULTS: The national results for most quality indicators on diagnosis and systemic therapy were around the predefined target value. Other indicators showed results below the benchmark: genetic testing, completeness of staging surgery, lymphadenectomy with at least 20 pelvic/para-aortic lymph nodes removed, and timely start of chemotherapy after surgery (within 42 days). Ovarian cancer care in Belgium is dispersed over 100 hospitals. Lower volume hospitals showed poorer indicator results compared to higher volume hospitals for lymphadenectomy, staging, timely start of chemotherapy and genetic testing. In addition, surgery for advanced stage tumours was performed less often in lower volume hospitals.
CONCLUSIONS: The indicators that showed poorer results on a national level were also those with poorer results in lower-volume hospitals compared to higher-volume hospitals, consequently supporting centralisation. International benchmarking is hampered by different (surgical) definitions between countries and studies
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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