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What role does intracellular and intercellular signaling play in cardiac remodeling?
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Dialogues in Cardiovascular Medicine
Volume 20, Issue 2, 2015, Pages 107-118
What role does intracellular and intercellular signaling play in cardiac remodeling? (Article)
Rizzo, P.a ,
Ameri, P.b
a Department of Morphology, Surgery, and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
b Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
View references (99)
Abstract
Pathological cardiac remodeling leads to progressive worsening of cardiac function and heart failure. Novel and more effective therapeutic strategies are needed to slow down or reverse this often fatal process. The dissection of the molecular events underlying cardiac remodeling could lead to the identification of promising new candidates for targeted treatment of heart failure. In this review, we discuss the role of the Notch and Akt (protein kinase B) signaling pathways in mediating intercellular and intracellular events that play an important role in the myocardium under physiological and pathological conditions, including remodeling
What is the role of the Notch pathway in cancer-induced cardiotoxicity?
No full textCancer mortality has been steadily decreasing in the recent years due to aggressive prevention strategies and to the development of treatments tailored for that particular type of cancer. Some of these treatments, including not only chemotherapeutics drugs but also targeted agents such as trastuzumab, are associated to cardiotoxicity that can be so extreme to cause death due to cardiovascular causes instead of cancer. Even though the mechanisms of cardiotoxicity are not fully understood, it is becoming clear that some cancer treatments have detrimental effects on survival of cardiomyocytes and endothelial cell in the myocardium. Notch is a key pathway involved in modulating proliferation and survival of both cell types. An understanding of how the Notch pathway in cardiomyocytes and endothelial cells is affected by cancer treatments could lead to the development of new protocols to limit or reduce cancer therapy associated cardiotoxicity
The Notch pathway: A new therapeutic target in atherosclerosis?
No full textThe Notch signalling is a fundamental pathway involved in the modulation of cell proliferation, survival, and in stem cells maintenance. The crucial role played by Notch in tumour onset and progression has made it amenable to cancer therapy. Several clinical trials are currently testing safety and efficacy of combination treatments of existing cancer therapies with Notch inhibitors. Notch receptors and their ligands play a major role in the modulation of a plethora of biological functions of macrophages, endothelial, and vascular smooth muscle cells, particularly under inflammatory conditions. Data obtained by us and other laboratories provide compelling evidence that the Notch signalling, by affecting the biology of each cell type involved in atheromatous plaque formation, has the potential to become a new biomarker and/or therapeutic target in atherosclerosis
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