10,245 research outputs found
Relating the fossil record to deglaciation in the early Permian of Gondwana : development of a Gondwana-wide biotic deglaciation model
No full textThe incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.
No full textBACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing enzymes. This study evaluated whether the polymorphisms in these enzymes were associated with an increased risk of anti-TB drug-induced hepatitis in patients and could potentially be used to identify patients at risk of liver injury. METHODS AND DESIGN: In a cross-sectional study, 2244 tuberculosis patients were assessed two months after the start of treatment. Anti-TB drug-induced liver injury (ATLI) was defined as an ALT, AST or bilirubin value more than twice the upper limit of normal. NAT2, CYP2E1, GSTM1 and GSTT1 genotypes were determined using the PCR/ligase detection reaction assays. RESULTS: 2244 patients were evaluated, there were 89 cases of ATLI, a prevalence of 4% 9 patients (0.4%) had ALT levels more than 5 times the upper limit of normal. The prevalence of ATLI was greater among men than women, and there was a weak association with NAT2*5 genotypes, with ATLI more common among patients with the NAT2*5*CT genotype. The sensitivity of the CT genotype for identifying patients with ATLI was 42% and the positive predictive value 5.9%. CT ATLI was more common among slow acetylators (prevalence ratio 2.0 (95% CI 0.95,4.20) )compared to rapid acetylators. There was no evidence that ATLI was associated with CYP2E1 RsaIc1/c1genotype, CYP2E1 RsaIc1/c2 or c2/c2 genotypes, or GSTM1/GSTT1 null genotypes. CONCLUSIONS: In Xinjiang Uyghur TB patients, liver injury was associated with the genetic variant NAT2*5, however the genetic markers studied are unlikely to be useful for screening patients due to the low sensitivity and low positive predictive values for identifying persons at risk of liver injury
Lower Permian brachiopods and palynomorphs of the Alborz Mountain (North Iran) and their palaeobiogeographical affinity
No full textEdosa robinsoni Yang, Wang & Li, sp. nov.
No full text<i>Edosa robinsoni</i> Yang, Wang & Li, sp. nov. <p>(Figs 2, 17 b, 18b, 28, 59, 84)</p> <p> <b>Type material.</b> Holotype ♂, <b>CHINA:</b> Mt. He (22°45'N, 112°57'E), Guangdong Province, 10.x.2002, leg. Guilin Liu & Binglan Zhang, genitalia slide No. XYL03174.</p> <p> <b>Paratypes: CHINA: Guangdong Province:</b> 1 ♂, Mt. He, 26.viii.2002, leg. Guilin Liu, genitalia slide No. XYL05039. <b>Fujian Province</b>: 1 ♀, Xiamen University Botanical Garden (24°26΄N, 118°06΄E), 85 m, 7.viii.2012, leg. Zhibo Wang & Zhenguo Zhang; 1 ♂, Xiamen University Botanical Garden, 85 m, 24.ix.2012, leg. Zhibo Wang. <b>Guangxi Zhuang Autonomous Region:</b> 1 ♂, Pingxincun, Yizhou (24°30΄N, 108°40΄E), 150 m, 16.viii.2011, leg. Shulian Hao & Yinghui Sun, genitalia slide No.YLL11114. <b>Hong Kong</b>: 2 ♂, Kadoorie Agricultural Research Centre (22°25΄N, 114°06΄E), 210 m, 17,21. iv.2007, leg. Houhun Li <i>et al.</i>, genitalia slide No. XYL08079; 2 ♀, Gaotang, Xigong (22°24΄N, 114°19΄E), 100 m, 25.ix.2009, leg. Houhun Li <i>et al.</i>, genitalia slide Nos. YLL11154, YLL11157.</p> <p> <b>Diagnosis.</b> This new species is similar to <i>E. hamata</i> <b>sp. nov.</b> superficially, but can be recognized by having a subtriangular medial process on the costal margin of the valva, which is absent in the latter species.</p> <p> <b>Description.</b> Adult (Fig. 28). Wingspan 10.0−11.5 mm in male. Head dull orange yellow. Antenna dusty yellow, as long as forewing; scape with a few black pecten bristles; flagellum unicolorous. Labial palpus with first and second segments yellowish brown tinged with darker scales on inner surface, dark brown on outer surface; third second yellowish brown, dark brown at base on outer surface. Thorax and tegula blackish brown. Forewing index 0.28−0.3, grayish black, shining dark purple, individual scales uniformly colored; retinaculum present; cilia grayish black, cilia line ill-defined. Hindwing pale grayish brown; male with a single short, slender evenly curved frenular bristle, female with two slender bristles, shorter one 0.7× length of longer one; cilia grayish brown in basal 1/3, pale gray in distal 2/3. Fore leg purplish brown; mid leg purplish brown, tarsus yellowish brown mixed with darker scales on ventral surface; hind leg yellowish brown.</p> <p>Pregenital abdomen. In male, first tergum with medial 1/3 sclerotized; coremata present in eighth segment; eighth sternite 0.25× as long as wide, without caudal process; eighth tergite trapezoidal, without caudal process. In female, seventh sternite semicircularly concave at middle on posterior margin.</p> <p>Male genitalia (Fig. 59). Vinculum with anterior and posterior margins parallel sided; medial process absent from ventrocaudal margin. Tegumen as deep as vinculum, semicircularly concave on anterior margin, convex at middle on posterior margin. Uncus with shouldered base forming a trapezoidal membraneous section with tegumen; uncus lobe as long as depth of vinculum, twisted at middle, basal half slightly expanded, punctate, distal half heavily sclerotized, hooked, smooth dorsally, hairy ventrally, apex melanized; sclerite absent between uncus lobes. Valva triangular, narrowed basally, sharply widened at 1/4, then narrowing to blunt apex; costal margin bearing small dentations at base, with a subtriangular medial process; basal flange large, smooth, hooked; bridging lobe absent between basal flange and valva; ventral margin with deep ventral lobe; basal margin with inconspicuous ‘secondary apodeme’ close to apodeme; inner surface unmodified. Juxta angled caudally, short and flat. Aedeagus stout, 1.5× length of valva, basal half being a pair of paddle-shaped sclerites, apex deeply concave at middle, dentate on dorsal surface of concavity. Bulbus ejaculatorius 3.0× length of aedeagus, slightly expanded at base, where ductus ejaculatorius is coiled, subdistal section not hypertrophied, distal section slightly expanded.</p> <p>Female genitalia (Fig. 84). Ovipositor length 1.5 mm. Eighth tergite funnel-shaped, anterior 2/3 membraneous, tapered, forming slender process at middle on anterior margin; posterior half microtrichiate, with scattered setae near posterior margin. Eighth sternite rectangular, with sparse setae medially; anterior margin straight, posterior margin concave, slightly folded inward, forming a pair of shallow pockets posterolaterally. Ostium at middle of posterior margin of eighth sternite. Antrum weakly sclerotized; ductus bursae about 0.5× length of corpus bursae. Colliculum comprising a pair of sclerotized base-joined narrow bands extending from junction of ductus bursae and corpus bursae, crossing second ring to anterior end of corpus bursae; second ring at posterior 1/4 of corpus bursae, anteriorly produced to an elongate lance-like dorsal process with end extending to anterior 1/4 of corpus bursae; inception of ductus seminalis at middle on posterior margin of lance-like process of second ring. Corpus bursae ovate; signum absent.</p> <p> <b>Distribution.</b> China (Fujian, Guangdong, Guangxi, Hong Kong).</p> <p> <b>Etymology.</b> This species is named after the late Dr. Gaden S. Robinson for his great contribution to the study of Tineidae, and for commemorating the friendship between him and the corresponding author.</p>Published as part of <i>Yang, Linlin, Wang, Shuxia & Li, Houhun, 2014, A taxonomic revision of the genus Edosa Walker, 1886 from China (Lepidoptera, Tineidae, Perissomasticinae), pp. 1-102 in Zootaxa 3777 (1)</i> on pages 21-22, DOI: 10.11646/zootaxa.3777.1.1, <a href="http://zenodo.org/record/249826">http://zenodo.org/record/249826</a>
Distributed human computation framework for linked data co-reference resolution
No full textDistributed Human Computation (DHC) is a technique used to solve computational problems by incorporating the collaborative effort of a large number of humans. It is also a solution to AI-complete problems such as natural language processing. The Semantic Web with its root in AI is envisioned to be a decentralised world-wide information space for sharing machine-readable data with minimal integration costs. There are many research problems in the Semantic Web that are considered as AI-complete problems. An example is co-reference resolution, which involves determining whether different URIs refer to the same entity. This is considered to be a significant hurdle to overcome in the realisation of large-scale Semantic Web applications. In this paper, we propose a framework for building a DHC system on top of the Linked Data Cloud to solve various computational problems. To demonstrate the concept, we are focusing on handling the co-reference resolution in the Semantic Web when integrating distributed datasets. The traditional way to solve this problem is to design machine-learning algorithms. However, they are often computationally expensive, error-prone and do not scale. We designed a DHC system named iamResearcher, which solves the scientific publication author identity co-reference problem when integrating distributed bibliographic datasets. In our system, we aggregated 6 million bibliographic data from various publication repositories. Users can sign up to the system to audit and align their own publications, thus solving the co-reference problem in a distributed manner. The aggregated results are published to the Linked Data Cloud
Historical Background of Wang Yang-ming’s Philosophy of Mind
No full textThis open access book offers comprehensive information on Wang Yang-ming’s life, helping readers identify and grasp the foundations on which his philosophy was established. Though a great man, Wang had an extremely difficult life, full of many hardships. Based on various official histories, Wang’s own writings, and his disciples’ records, the book explores the legendary life of this ancient philosopher, who not only diligently pursued his objective of living as a sage, but also persistently sought the ideal state of a sage in ideology. The author also shares his own interpretations of the main aspects of Wang’s philosophy using simple and straightforward language. This book will help readers understand and appreciate Wang Yang-ming’s extraordinary life, his generous mind, deep thoughts and bright personality, inspiring them to pursue enriching lives. It offers a unique and insightful work for undergraduate students and all others interested in Wang’s philosophy and life story
Historical Background of Wang Yang-ming’s Philosophy of Mind
No full textThis open access book offers comprehensive information on Wang Yang-ming’s life, helping readers identify and grasp the foundations on which his philosophy was established. Though a great man, Wang had an extremely difficult life, full of many hardships. Based on various official histories, Wang’s own writings, and his disciples’ records, the book explores the legendary life of this ancient philosopher, who not only diligently pursued his objective of living as a sage, but also persistently sought the ideal state of a sage in ideology. The author also shares his own interpretations of the main aspects of Wang’s philosophy using simple and straightforward language. This book will help readers understand and appreciate Wang Yang-ming’s extraordinary life, his generous mind, deep thoughts and bright personality, inspiring them to pursue enriching lives. It offers a unique and insightful work for undergraduate students and all others interested in Wang’s philosophy and life story
Identification of Immune Gene Signature Associated with T Cells and Natural Killer Cells in Type 1 Diabetes [Corrigendum]
No full textWang N, Wang G, Feng X, Yang T. Diabetes Metab Syndr Obes. 2024;17:2983—2996.
The authors have advised the affiliation callouts in the author list on page 2983 are incorrect. The correct author callouts should read as follows:
Na Wang1, Guofeng Wang1,2, Xiuli Feng1, Teng Yang
One step preparation of pure tau-MnAl phase with high magnetization using strip casting method
No full textFerromagnetic phase of Mn-Al exhibits great potential in the rare-earth free permanent magnetic materials due to its high magnetocrystalline anisotropy, high magnetization, high Curie temperature and low cost. In this work, the strip casting technique was applied to prepare MnAl magnetic phase. X-ray diffraction and energy dispersive X-ray analyses indicate that the as-prepared Mn54Al46 strip sample consists of pure tau-MnAl magnetic phase. It is found that the composition of Mn54Al46 is suitable to prepare tau-MnAl phase during the strip casting process. The Mn54Al46 strip sample synthesized through the strip casting exhibits a fairly high magnetization of 114 emu/g under a field of 5 T, while the coercivity of iHc = 2.8 kOe, magnetization of M-5T = 63.9 emu/g at room temperature can be obtained for Mn54Al46 powder sample. This preparation method can produce a large amount of tau-phase MnAl alloy and promote mass industrialized production. (C) 2017 Author(s)
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