9 research outputs found
Giant leiomyoma of the gastroesophageal junction: technique and results of endoscopic full-thickness resection
No full textDavide Bona, Alberto Aiolfi, Stefano Siboni, Daniele Bernardi, Luigi BonavinaDepartment of Surgery, IRCCS Policlinico San Donato, University of Milano School of Medicine, Milano, ItalyAbstract: Four consecutive patients with a giant leiomyoma originating from the posterior aspect of the gastroesophageal junction were treated with full-thickness endoscopic retroflex dissection. A complete removal of the lesion was obtained in all cases. No complications were observed except for some degree of air filtration causing symptomatic pneumoperitoneum in one patient. Retroflex endoscopic full-thickness resection of giant leiomyoma at the gastroesophageal junction is feasible and safe.Keywords: gastroesophageal junction, leiomyoma, endoscopic submucosal dissection, pneumoperitoneu
Management of Pregnancy, Delivery, and Postpartum in Italian Carriers and Women With Haemophilia A and B
No full textIntroduction: Managing pregnancy in carriers/women with haemophilia involves four key objectives: preconception and prenatal care, minimizing maternal bleeding, choosing the delivery mode to reduce foetal/neonatal bleeding, and postpartum care. The optimal factor VIII/IX level at delivery and the best delivery method to mitigate maternal and foetal complications are still debated. Aim: To share real-world clinical management in Italian haemophilia treatment centres. Methods: In March-April 2023, members of the Italian Association of Hemophilia Centers "AICE" were invited to an online survey to collect information on the management of pregnancy, delivery, and postpartum in carriers/women with haemophilia. Results: Thirty-three centres responded. Plasma FVIII/FIX levels are systematically evaluated in the third trimester, considering a threshold above 50 U/dL essential for safe delivery and neuraxial analgesia. Overall, the haematologic counselling on delivery mode generally aligns with obstetric indications in 73% of centres. In women who will give birth to a known affected male foetus, 55% rely on obstetric indication, while 24% suggest spontaneous delivery and 21% planned caesarean section. Excluding those which follow obstetric indication, natural delivery and planned caesarean section are recommended respectively by 40% and 60% when prenatal diagnosis is available or by 20% and 80% when not available. All centres agree to avoid instrumental delivery in affected male foetus or when prenatal diagnosis has not been made. Conclusion: Multidisciplinary pregnancy management is recommended. Delivery mode choice is primarily driven by ensuring the newborn's maximum protection. However, the use of caesarean section should also be weighted according to the mother's risk profile
Transoral septotomy versus Z-POEM in the treatment of Zenker diverticulum: a multicenter case-matched comparative study
No full textIntroduction: Transoral septotomy has become the favored treatment of Zenker Diverticulum (ZD), with POEM becoming a mini-invasive option also in ZD. The gold-standard treatment of ZD is still debated. We designed a case-matched comparative study to evaluate whether POEM (Z-POEM) could be as effective as stapler, traction-assisted Transoral Septotomy (TS) as first-line treatment of ZD. Materials and methods: Consecutive naïve patients between 2015 and 2022 were enrolled in two high-volume centers. Barium-swallow and endoscopy were performed before and after surgery. Symptoms were assessed using a dedicated questionnaire. A control group was generated by matching patients who underwent Z-POEM with those who underwent TS. For matching the patients, a one-to-one nearest neighbor approach was used. Patients were matched for: septum length, symptoms duration, age, and sex. Results: After matching, 26 patients in each group were enrolled. The procedures were completed successfully in all patients in both groups, and mortality was null. TS required a shorter operative time. One leakage was detected in the Z-POEM group while one mucosal tear was detected in the TS group, both treated conservatively. At a median follow-up of 45 months (IQR: 27-68) for TS and 66 months (IQR: 58-76) for Z-POEM, a successful outcome was achieved in 96.2% in both groups. Post-operative symptom scores decreased in all patients in both groups. Conclusions: This is the first study comparing Z-POEM and TS. Both the minimally invasive treatments are effective for naïve Zenker Diverticulum. TS provides a lower rate of intraoperative complications and a shorter operative time
Kierkegaard and the Copenhagen Production of Mozart’s <i>Don Giovanni</i>
No full textThe article explores the early performance history of Mozart’s Don Giovanni (1787) at Copenhagen’s Royal Theatre, as a context for Søren Kierkegaard’s famous essay on the opera, which appeared in his philosophical work Either/Or: A Fragment of Life (1843). Focusing on the treatment of the supernatural elements in the opera, the author examines Lauritz Kruse’s Danish singspiel translation of the libretto, which was used by the theater from 1807 to 1839. Kruse turned Lorenzo Da Ponte’s enlightened comedy of manners into a romantic tragedy with religious overtones, but his radical reconceptualization of the drama conflicted with the portrayal of the title role by the Danish-Italian baritone Giovanni Battista Cetti who was the Don Giovanni of Copenhagen’s Royal Theatre from 1822 to 1837, and who partly inspired Kierkegaard’s interpretation. Cetti performed the role as a charming and sympathetic character, probably due to the influence of his teacher Giuseppe Siboni who, in his turn, was probably influenced by Luigi Bassi’s portrayal, the singer for whom Mozart had written the role. Hence the responses of Kierkegaard and other contemporary writers to Mozart’s seducer may be read as attempts to find meaning in a dramaturgically incongruous production.</p
Survey Removal Efficiency of Cadmium from Aqueous Solutions Using Commercial Aluminum nano oxide: Kinetic Study of the Equilibrium
No full textHealth-related quality of life and psychological well-being in elderly patients with haemophilia
No full textEffect of Ozonation and Hydrogen Peroxide on Reducing the Volume and Chemical Oxygen Demand of Waste Water Treatment Plants Sludge
No full textData Descriptor: Systematic, continental scale temporal monitoring of marine pelagic microbiota by the Australian Marine Microbial Biodiversity Initiative
No full text© 2018 Author(s). Sustained observations of microbial dynamics are rare, especially in southern hemisphere waters. The Australian Marine Microbial Biodiversity Initiative (AMMBI) provides methodologically standardized, continental scale, temporal phylogenetic amplicon sequencing data describing Bacteria, Archaea and microbial Eukarya assemblages. Sequence data is linked to extensive physical, biological and chemical oceanographic contextual information. Samples are collected monthly to seasonally from multiple depths at seven sites: Darwin Harbour (Northern Territory), Yongala (Queensland), North Stradbroke Island (Queensland), Port Hacking (New South Wales), Maria Island (Tasmania), Kangaroo Island (South Australia), Rottnest Island (Western Australia). These sites span ~30° of latitude and ~38° longitude, range from tropical to cold temperate zones, and are influenced by both local and globally significant oceanographic and climatic features. All sequence datasets are provided in both raw and processed fashion. Currently 952 samples are publically available for bacteria and archaea which include 88,951,761 bacterial (72,435 unique) and 70,463,079 archaeal (24,205 unique) 16 S rRNA v1-3 gene sequences, and 388 samples are available for eukaryotes which include 39,801,050 (78,463 unique) 18 S rRNA v4 gene sequences
Data Descriptor: Systematic, continental scale temporal monitoring of marine pelagic microbiota by the Australian Marine Microbial Biodiversity Initiative
No full text© 2018 Author(s). Sustained observations of microbial dynamics are rare, especially in southern hemisphere waters. The Australian Marine Microbial Biodiversity Initiative (AMMBI) provides methodologically standardized, continental scale, temporal phylogenetic amplicon sequencing data describing Bacteria, Archaea and microbial Eukarya assemblages. Sequence data is linked to extensive physical, biological and chemical oceanographic contextual information. Samples are collected monthly to seasonally from multiple depths at seven sites: Darwin Harbour (Northern Territory), Yongala (Queensland), North Stradbroke Island (Queensland), Port Hacking (New South Wales), Maria Island (Tasmania), Kangaroo Island (South Australia), Rottnest Island (Western Australia). These sites span ~30° of latitude and ~38° longitude, range from tropical to cold temperate zones, and are influenced by both local and globally significant oceanographic and climatic features. All sequence datasets are provided in both raw and processed fashion. Currently 952 samples are publically available for bacteria and archaea which include 88,951,761 bacterial (72,435 unique) and 70,463,079 archaeal (24,205 unique) 16 S rRNA v1-3 gene sequences, and 388 samples are available for eukaryotes which include 39,801,050 (78,463 unique) 18 S rRNA v4 gene sequences
