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The IAAF’s hyperandrogenism regulations suspended
No full textOn 27 July, the Court of Arbitration for Sport (‘CAS’) delivered a landmark ruling on the regulation of gender in sport. The decision explores how the categorisation of sport on the basis of sex can be best reconciled with the “biological reality” that human sex cannot necessarily be divided so clearly. Dr. Seema Patel, Senior Lecturer at Nottingham Trent University, Deputy Director of the Centre for Sports Law and author of ‘Inclusion and Exclusion in Competitive Sport: Socio-Legal and Regulatory Perspectives,’ reviews the case and suggests that sport regulation must be cautious of traditional criteria to determine eligibility in sports
Jun N-terminal kinase 1 (JNK1) as a molecular target to limit cellular mortality under hypoxia
No full textMany pathological conditions and environmental impacts lead to a decrease in tissue oxygen supply and severe cellular hypoxia. This secondary hypoxia can disturb cellular homeostasis, limiting the efficacy of the prescribed treatment for the primary disease, eventually leading to cellular and organismal death. Jun N-terminal kinase 1 (JNK1) plays a central role in the development of cellular damage under hypoxia, hypoxia/reoxygenation and ischemia/reperfusion conditions. Therefore, we selected JNK1 protein as a molecular target to limit cellular damage and death during hypoxia. The primary objective of this research was to study the influence of the suppression of JNK1 on the development of cellular hypoxic damage. It was hypothesized that suppression of JNK1 will decrease cellular mortality under hypoxia and may increase the efficacy of traditional treatment of many pathological conditions. The hypothesis was verified under both in vitro and in vivo conditions. Another objective was to develop a non-viral system for intracellular delivery of antisense oligonucleotides (ASO) and small interfering RNA (siRNA). ASO and siRNA targeted to JNK1 mRNA delivered by neutral and cationic liposomes, respectively, showed high efficiency in suppressing JNK1 protein. Such suppression limited the caspase dependent apoptosis signaling pathway and decreased cellular mortality induced by severe hypoxia. The results suggest that JNK1 protein might be an attractive target for antihypoxic therapy to increase resistance to many pathological conditions and diseases accompanied by cellular hypoxia.Ph.D.Includes bibliographical references (p. 138-153)by Seema S. Betiger
The Post Office Horizon system and Seema Misra
No full textThe author highlights the significance of the Seema Misra case in raising questions about the reliablity of the Post Office Horizon system and more widely suggesting that all digital systems have the possibility of latent defects, and these can never be discounted. He argues that when the efficacy of digital systems is called into question in legal proceedings, the onus of proof must be placed on the supplier of these systems and not the accuser.Index words: Post Office; Horizon; prosecutions; software errors; disclosure Full transcript of the trial Regina v Seema Misra, T2009007 (England & Wales; theft; electronic evidence; Post Office Horizon System; ‘reliability’ of computers) with case commentary and index to original papers held in the Documents Supplement of Volume 12: 2015
Development of novel zein-cellulose nanocomposite films
No full textZein is a hydrophobic biopolymer, which naturally forms biodegradable films. These films are rigid, brittle, and lack good mechanical and barrier properties for packaging applications. This study aims at improving the mechanical and barrier properties of zein films by the development of zein-cellulose nanocomposites. A ‘nanocomposite’ is a mixture of polymer matrix, which forms the continuous phase and the filler (having at least one dimension less than 100nm), which forms the dispersed phase. Zein-cellulose nanocomposites have zein as the matrix and cellulose as the filler. Nano-sized cellulose was prepared using wet-media milling machine and mass ratios of 1%, 3%, 5% and 10% of both, naked (not stabilized) nano-cellulose and GA - stabilized nano-cellulose were used in the film formulation. Tributyl citrate (TBC) was used as the plasticizer. The films were prepared using solvent-cast technique and characterized to test their mechanical and barrier properties. The controls were pure zein films and films with only plasticizer. Texture Analysis showed that filler loading of 5% was most effective in increasing the elongation-at-break to about 16 to 20 times of the controls. However, the tensile strength did not change. Water vapor permeability of the nanocomposites was minimum at 1% by wt. of naked cellulose (~4 times less than control) or at 5% by wt. of stabilized cellulose (~6 times less than control). Water absorption results showed that the rate of water uptake decreased as the filler loading increased. DSC and FTIR suggested that there is no interaction between the zein and the nano-cellulose in the films. The AFM results showed that the films’ surface is flat, but the thickness of the films increased with filler loading. Therefore, incorporation of nano-cellulose improved the flexibility and water barrier properties of the films. Gum Arabic, which was used as a stabilizer for nano-cellulose, seemed to have aided the even distribution of cellulose in the zein matrix. Thus, these films can be a good starting point to further study the arrangement of cellulose within the zein matrix and test its potential applications on food systems and as edible films.M.S.Includes bibliographical referencesby Seema Lakshmana Ra
Not Available
No full textVersion: 1.0.0
Imports: utils, minimalRSD, stats
Published:2017-03-21
Author: Shwetank Lall [aut, cre], Arpan Bhowmik [ctb], Eldho Varghese [aut], Seema Jaggi [ctb], Cini Varghese [ctb]
Maintainer: Shwetank Lall
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Citation: FMC citation info
In views: ExperimentalDesignAn R package to generate cost effective minimally changed run sequences for symmetrical as well as asymmetrical factorial designsNot Availabl
FUZZY ROUGH INFORMATION MEASURES AND THEIR APPLICATIONS
No full textFUZZY ROUGH INFORMATION MEASURES AND THEIR APPLICATIONS
Seema Singh1, D.S. Hooda2, S.C. Malik3
1&3Department of Statistics, M.D. University, Rohtak-124001, Haryana, India
2Honorary Professor of Mathematics, G.J. University of Science and
Technology, Hisar- 125001, Haryana, India
Corresponding Author – D.S. Hooda
ABSTRACT
The degree of roughness characterizes the uncertainty contained in a rough set. The rough entropy was
defined to measure the roughness of a rough set. Though, it was effective and useful, but not accurate
enough. Some authors use information measure in place of entropy for better understanding which
measures the amount of uncertainty contained in fuzzy rough set .In this paper three new fuzzy rough
information measures are proposed and their validity is verified. The application of these proposed
information measures in decision making problems is studied and also compared with other existing
information measures.
KEYWORDS AND PHRASES
Fuzzy Rough Set, Similarity Information Measure, Logarithmic Information Measure, Weighted
Information Measure and Decision Making Proble
Disparity plots for undirected Macaque network and its null models.
No full text<p>(a) Top plot: Black empty squares plot disparity against SV for all local subnetworks of the Macaque network. The mean SV of these subnetworks for each disparity value is plotted using the blue curve with filled circles. (b) Middle plot: the blue curve with crosses plots the mean degree of the hub of the subnetworks with the same disparity value. Mean values in the top and middle plot are plotted for different null models using the color legend shown in the bottom plot. (c) Bottom plot: Normalized histogram of local subnetworks for each disparity value, for each network. For ISO, MS, B-MS null models results are averaged over 20 realizations.</p
Energy consumption at the state level: The unit root null hypothesis from Australia
No full textIn this paper, our goal is to examine the unit root null hypothesis in energy consumption for Australian states and territory. We consider sectoral energy consumption for Australia and its six states and one territory using time series data for the period 1973-2007. This is the first study that does this. Generally, except for some cases in South Australia, we find strong support that shocks to energy consumption have a temporary effect on energy consumption in Australia.Unit root Energy consumption Australia
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