30 research outputs found
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
No full textThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Analytical study of contents of LANL physics and cross-listed e-print archives, 1994-2002
No full textThe frontiers of physics and cross-listed e-print archives posted during the years 1994-2002 at http://www.arxiv.org/archives/physics web service of Los Alamos National Laboratory (LANL) are explored from 7770 submissions. E-print archives posted to top most six physics-cross-listed research categories besides physics (5390) are: Condensed matter (754), Quantum physics (279), Astrophysics (222), Chemical physics (129), High energy physics - Phenomenology (118), and High energy physics-Theory (100). Prominent contributors are B.G. Sidharth (India), V.V. Flambaum (Australia), Antonina N. Fedorova (Russia), and Michael G. Zeitlin (Russia). Most preferred journals for rechannelising e-print archives are Physical Review Letters, Physical Review A, Physical Review E, Nuclear Instruments and Methods A, and Journal of Chemical Physics
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No full textThe Cloud of Things (CoT) is the multi-domain, emerging, and dynamic technology in today's era. Cloud of Things can perform security services and virtualization with different sensor devices for a powerful and scalable high-performance computing. The author emphasizes the evaluation of various applications used in Cloud of Things. The chapter has been this chapter is divided into two parts which cover the significance of the Cloud and Internet of Things. The chapter focuses on introduction of the Cloud, IoT, and CoT and shows the security and challenges occurring in CoT. It also covers the security issues in IoT with different applications. The chapter will help the academician, researchers, and industry professional to further investigate the associated area of Cloud IoT, and it also helps them find solutions from different perspectives. </jats:p
Loss of Diacylglycerol Kinase Epsilon in Mice Causes Endothelial Distress and Impairs Glomerular Cox-2 and Pge(2) Production
No full textThrombotic microangiopathy (TMA) is a disorder characterized by microvascular occlusion that can lead to thrombocytopenia, hemolytic anemia, and glomerular damage. Complement activation is the central event in most cases of TMA. Primary forms of TMA are caused by mutations in genes encoding components of the complement or regulators of the complement cascade. Recently, we and others have described a genetic form of TMA caused by mutations in the gene diacylglycerol kinase-epsilon (DGKE) that encodes the lipid kinase DGK(epsilon) (Lemaire M, Fremeaux-Bacchi V, Schaefer F, Choi MR, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji WZ, Overton JD, Mane SM, Nurnberg G, Altmuller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nurnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Nat Genet 45: 531-536, 2013; Ozaltin F, Li BH, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang CY, Chen P, Lu DM, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. J Am Soc Nephrol 24: 377-384, 2013). DGKe is unrelated to the complement pathway, which suggests that unidentified pathogenic mechanisms independent of complement dysregulation may result in TMA. Studying Dgke knockout mice may help to understand the pathogenesis of this disease, but no glomerular phenotype has been described in these animals so far. Here we report that Dgke null mice present subclinical microscopic anomalies of the glomerular endothelium and basal membrane that worsen with age and develop glomerular capillary occlusion when exposed to nephrotoxic serum. We found that induction of cyclooxygenase-2 and of the proangiogenic prostaglandin E-2 are impaired in Dgke null kidneys and are associated with reduced expression of the antithrombotic cell adhesion molecule platelet endothelial cell adhesion molecule-1/CD31 in the glomerular endothelium. Notably, prostaglandin E-2 supplementation was able to rescue motility defects of Dgke knockdown cells in vitro and to restore angiogenesis in a test in vivo. Our results unveil an unexpected role of Dgke in the induction of cyclooxygenase-2 and in the regulation of glomerular prostanoids synthesis under stress.Wo
Citation analysis of LANL High-Energy Physics E-Prints through Science Citation Index (1991-2002)
No full textThis investigation provides evidence that e-prints are an integral component of the scholarly communication of physicists. This was especially shown to be the case for the area of high-energy particle physics. The magnitude of importance is perhaps even greater than reported as the data collected from the Science Citation Index (SCI) are likely to be an underestimation, the reason may be because of the coverage of journals by SCI and the reason for the citations for the e-print archives after publication may be the absence of details in the records of e-print archives. The present study shows only the trends analysis.
Among the e-print archives studied in the four different categories of high-energy physics at least 39 percentages have cited at least once from each category in Science Citation Index (1991-2002). The over all Gini’s Coefficient was found to be 0.65. The minimum average citation to the e-print archives in the four categories was 2.73. The citing patterns of highly cited e-print archives vary widely. More than 60-70 percentages of citations are received immediately after posting the e-print archives on the site. The high-energy physics e-prints are cited heavily up to they have published in formal sources.
The Impact Factors of journals citing high-energy physics e-print archives are very high. The citing journals are very important and influential in their respective domains. Physics Letters B, Physical Review D, Nuclear Physics B, Nuclear Physics B-Proceedings Supplements, Physical Review Letters, Modern Physics Letters A, Nuclear Physics A, and Classical and Quantum Gravity are some of the most influential citing journals in the field. They are coming in some order in the highly citing journals in the four categories. There is not much relation with the Impact Factors and the number of times cited e-print archives.
The number of authors citing high-energy physics e-print archives is increasing yearly by a factor of around 1.25 increasing in the ratio. The Lotka’s Law (normally is being applied for publication productivity of authors) is almost holds hood for the information use by authors in the case of citing high-energy physics e-print archives. There are many authors who are citing all the four categories of LANL high-energy physics e-print archives.
USA, Italy, Germany, Japan, England, Russia, and Switzerland are the countries occurring in the affiliation of authors citing e-print archives frequently. The researchers from these countries are more utilizing the services of LANLs high-energy physics e-print archives.
The current results also show that the level of the use and importance of e-prints to physicists because they only measure the use of e-prints by the journal literature and not the e-print literature as itself. Scientists are virtually replacing regular journal reading with daily consultation of LANL’s e-print archives. This study particularly highlights the importance of e-prints to high energy particle physicists. This microcosm within the physics community appears to be unique in its quest for up-to-the-minute research findings and in its willingness to share data before it has undergone the time honored peer review process. This self-monitoring, informal peer review by the high energy particle community ensures that the quality of their e-prints is of high caliber thereby validating the importance of e-prints in the cycle of scholarly communication.
Despite the many advantages of e-prints including: immediate; modifiable; updateable; inexpensive; unlimited size, their use has yet to overtake that of traditional journals [Brown, 2001b]. This may be a result of the policy of many journal editors and publishers disallowing manuscripts already published electronically [Harter and Park 2000; Brown 2001b; Wilkinson 2001]. In parallel, Harter [1998] found that electronic journals, which possess the same advantageous qualities as e-prints, plus the added bonus of peer-review, have not yet made a significant impact on printed journal usage. Nonetheless, many agree with Boyce [2000] that "preprint servers are here to stay" as evidenced by their growth in other scientific disciplines [Koenig 2000; McConnell and Horton 1999; Eysenbach 2000]
Bifidobacteria on the spot: a genomics approach on population dynamaics and interactions in the intestinal tract
No full textThis thesis combines comprehensive microarray-based studies contributing to a better understanding of the role of bifidobacteria in relation to the human host. It reviews recently described modes of interaction between bifidobacteria and human gastrointestinal cells and highlights the unique characteristics of the genus Bifidobacterium that are indicative for its role in our gut. A microarray platform has been developed that enables genomic comparison of Bifidobacterium species originating from our gastrointestinal tract (GIT). Based on the obtained high-resolution data, species-unique genomic sequences could be identified. A large fraction of these predicted genes encode proteins belonging to the bifidobacterial glycobiome. An unique ability of the microarray platform is to zoom in on the strain level. Direct mapping of genomic hybridization patterns was applied on different B. breve isolates. This revealed a relatively high genomic variation, testifying for the existence of various subspecies within the species B. breve. Clustering of the same hybridization patterns resulted in clear grouping of isolates originating from the same infant, indicating specific niche adaption. Additionally, DNA extracts from Bifidobacterium populations from different infant fecal samples were analyzed. This enabled the analysis of the bifidobacterial population dynamics in breast- and formula-fed infants. The applied microarray platform showed the potential to monitor temporal development and effects of dietary regimens. The observed differences in the composition of bifidobacterial populations could be linked to dietary effects. Additionally, mapping of hybridization patterns enabled monitoring shifts in genomic content within one bifidobacterial species in time. Sequence analysis of DNA fragments showing discriminating hybridization characteristics, resulted in the selection of genes that are either conserved or strain-specific within the species B. breve. Next to studying genomic variation, transcript profiling experiments in both bifidobacterial cells and human intestinal epithelial cell lines were performed. Analysis of bifidobacterial transcriptional responses provided clear proof of transcriptional activity in bifidobacterial cells isolated from infant feces. To the best of our knowledge, this is the first demonstration of in situ activity of bifidobacteria in the human GIT. Furthermore, our results indicate a link between transcription patterns and the infants’ diet, as bifidobacteria in fecal samples from breast-fed infants showed differential transcriptional responses in comparison to those in fecal samples from formula-fed infants. Additionally, transcript sequence analysis revealed expression of genes that are homologous to genes known to be involved in folate production, testifying for the production of this important vitamin in early life. Finally, transcriptome analysis on human intestinal epithelial cells (HIECs) showed species-specific suppression by B. breve M-16V of genes upregulated by TNF-α. Other B. breve strains showed an extreme mild or no effect on TNF-α stimulation. Although we did not observe complete suppression of the TNF effect, we could show that apoptotic and immune regulatory pathways were affected by incubation with cells of B. breve M-16V. In conclusion, the work presented in the thesis, which formed part of a larger IOP Genomics project, contributed to an advanced insight in the interaction between bifidobacteria and the human host. Furthermore, it resulted in the development of genome-based molecular platforms suited for analyzing genomic diversity between and within species, as well as population dynamics in complex microbial communities. We anticipate that the molecular approaches pioneered in this thesis will be instrumental in the further elucidation of the host-microbe interactions in the GIT of human an other animals. <br/
Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus
No full textObjectives: To gain insights into the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) and identify potential drug targets through investigation of whole-blood human transcriptome. Methods: We analysed differentially expressed genes in peripheral blood from active central nervous system (CNS) lupus (n = 26) and active non-neuropsychiatric SLE (n = 38) patients versus healthy controls (n = 497) from the European PRECISESADS project (NTC02890121). We further explored dysregulated gene modules in active CNS lupus and their correlation with serological markers. Lastly, we performed regulatory network and druggability analysis. Results: Unsupervised weighted gene co-expression network analysis (WGCNA) revealed 23 dysregulated gene modules and two subgroups of active CNS lupus. The interferon gene module was prominently upregulated in subgroup 1, while the B cell, T cell, and cytotoxic/natural killer (NK) cell modules were downregulated. Subgroup 2 showed less marked dysregulation patterns. Subgroup 1 had lower estimated proportions of lymphoid cell subsets and proportionally more patients positive for anti-dsDNA antibodies compared to subgroup 2, pointing to molecularly distinct subgroups or misclassification of subgroup 2. In silico prediction algorithms demonstrated a greater anticipated response to anifrolumab, C3 inhibitors, and calcineurin inhibitors for patients in CNS lupus subgroup 1 compared with subgroup 2. Conclusions: Gene dysregulation patterns related to innate and adaptive lymphoid immunity separated active CNS lupus patients into two distinct subgroups with differential anticipated response to type I interferon, C3, and calcineurin inhibition. Our study provides a conceptual framework for precision medicine in NPSLE and implications for overcoming the major clinical challenge of attributing neuropsychiatric features to SLE versus other causes. © 2025 The Author
Author Correction: Genotype-stratified treatment for monogenic insulin resistance: a systematic review
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