77 research outputs found
How to set up in recruitment…
No full text A career in dentistry that runs in the family influenced Anisha from an early age. She now runs AJ's Dental Fairies Recruitment Agency Limited. She shares her tips here </jats:p
Case study on drivers of stormwater user fees in 3 Massachusetts communities
No full textThesis: M.C.P., Massachusetts Institute of Technology, Department of Urban Studies and Planning, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 66-71).Urban stormwater is a major source of pollution in U.S. water bodies. Addressing the problem of stormwater pollution at the municipal level can be expensive, from infrastructure maintenance to implementing regulatory best practices. These needs have put pressure on municipalities to look for a stable source of revenue that extends beyond general tax appropriations for public works projects. In this context, stormwater user fees have remained a hotly debated topic in local budget discussions and national forums about stormwater management. In comparison to the rest of the country, the adoption of fees in Massachusetts communities is plagued by low uptake. This thesis aims to understand the surprisingly small proliferation and early adaptation of stormwater user fees in Massachusetts by identifying the local drivers of fee adoption as an alternative to using local tax income in three communities: Chicopee, Fall River and Northampton. Through a descriptive case study approach using qualitative interviews and publicly available data, the research underscores four key drivers apparent in local fee adoption: financial pressure, local history, governance arrangements of budgets, and cost equity. Ultimately, communities face numerous tradeoffs that affect the momentum and intricacy of the fee adoption process. Lessons learned about the local drivers of stormwater user fees in these three cases are specifically applicable to the Massachusetts context, but can serve as a guide for other New England municipalities considering new fees.by Anisha Anantapadmanabhan.M.C.P
Interference Reduction in CDMA Systems Using Antenna Arrays
No full textThe field of wireless communications is growing at an explosive rate, covering many technical areas. The deployment of cellular systems is a success and as the subscriber population continues to grow at a rapid pace, service providers may get capacity problems due to limited available frequency spectrum. Consequently, service providers are forced to find methods of enhancing the coverage and the capacity of their cellular networks. A promising future method suggested is to utilize adaptive antennas, which has also been recognized as one potential economic approach. Adaptive base station antennas have been proposed as a means to achieve the requested longer range and higher capacity in cellular systems.
In WCDMA, there is large number of interferers present in the system due to frequency reuse factor of one. The large numbers of interferers in these systems require a beamforming technique and other methods like null forming that would efficiently suppress the power in the undesired direction at the same time maximizing the power in the desired direction. For these systems side lobe adjustment and null forming would be a simple solution towards suppressing intercell and intracell interference and hence improving CIR performance and placing the nulls in the direction of individual interferers.
In this dissertation, a beamforming algorithm is analyzed for flexible side lobe adjustment. The algorithm places a very low side lobe level over a large width in the beam pattern. The convergence of this algorithm is fast and requires only two to three iterations. This algorithm can also form nulls in the desired direction. This beamforming algorithm is suitable for uplink and downlink since it is based on the DOAs estimated in uplink. The null forming method, based on constrained mean square approximation is discussed, which forms the null in the desired direction.Thapar Institute of Engineering and Technology, Department of Electronics and Communicaito
The Romanticization of Mental Illness and Substance Abuse in Young Adult Media
No full textabstract: The following creative project defends that, whether intentionally or not, mental illness and substance abuse are inevitably romanticized in young adult media and discusses the dangers of this romanticization. This project is divided into three parts. The first part consists of psychological evaluations of the main characters of two popular, contemporary forms of young adult media, Catcher in the Rye by J.D Salinger and Euphoria by Sam Levinson. These evaluations use textual evidence and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) to determine what symptoms of psychopathology the characters appear to display. The second part consists of a self-written short story that is meant to accurately depict the life of a young adult struggling with mental illness and substance abuse. This story contains various aesthetic techniques borrowed from the two young adult media forms. The final part consists of an aesthetic statement which discusses in depth the aesthetic techniques employed within the short story, Quicksand by Anisha Mehra. (abstract
IDENTIFYING NEW COMPOUNDS CAPABLE OF INDUCING MODEL PHAGES
No full textMcMaster University MASTER OF SCIENCE (2020) Hamilton, Ontario
(Department of Biochemistry and Biomedical Sciences)
TITLE: Identifying new compounds capable of inducing model phages
AUTHOR: Anisha Nandy
SUPERVISOR: Dr. Alexander P. Hynes
NUMBER OF PAGES: xi, 80Prophages are the genomes of bacteriophages (phages, bacterial
viruses) that integrate into the chromosome of their host upon infection, lying dormant until conditions favour their reactivation. A cell harbouring a
prophage is called a lysogen, as, upon exposure to certain signals, the
prophage will initiate a replicative cycle ending in lysis of the host bacterium
and release of phages. This process is known as induction. Canonically,
induction occurs through activation of the bacterial SOS-response, a DNA repair cascade initiated by detection of DNA damage. Studies of prophage
induction have almost exclusively relied on challenges with compounds that
result in the initiation of the host SOS response.
Recent studies have identified some signals that affect prophage
induction independently of the SOS response, but these approaches have not
been systematic. To identify non-canonical triggers of prophage induction, I
screened 3,936 compounds against two model lysogens. The first, carrying
phage HK97, is a model for induction. The second, carrying phage Mu—a
prophage thought to be uninducible—serves as a control. Any compound
which inhibited bacterial growth in only our HK97 lysogen was considered to
have resulted in a phage-mediated response. The 171 compounds identified in this screen were then used to re-challenge the lysogen at a range of
concentrations and monitor the resulting release of free phages associated
with induction. Increases in phage counts were seen for 86 compounds. While 38 of these were known SOS activators, 49 were novel, ‘non-canonical’ inducers. Unexpectedly, the screening also revealed seven unique chemical inducers for the supposedly un-inducible model prophage, Mu.
The 56 new phage-inducers identified by this work include compounds
likely to be driving phage induction through non-canonical pathways. As
prophages are thought to respond to bacterial stress, these may reflect stressors acting through new mechanisms. Using these compounds as tools opens up an avenue to probe other stress pathways in bacteria, and, as evidenced by induction of Mu, potentially help discover new phages that don’t respond to canonical inducers.ThesisMaster of Science (MSc)Bacterial viruses (phages) can lie dormant as prophages in their host
bacterium until a signal triggers their activation, production of viruses, and
rapid killing of the host. This switch from dormant prophage to active phage called induction. Almost all molecules that result in prophage inductions
belong to a limited set of compounds which elicit a specific stress response in
bacteria.
Screening 3936 compounds for their ability to inhibit the growth of
bacteria carrying known prophages resulted in the identification of a small
subset associated with increased phage production. For one Escherichia coli
prophage—HK97, a model of induction—we found 49 compounds not
previously known as inducers. For another model prophage—Mu, a prophage
thought to be chemically uninducible—we identified seven such compounds.
These compounds will serve as tools to determine what signals prophages can respond to, and potentially identify new stress pathways of
interest in bacteria
Urinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse Model
No full textThe prevalence of renal stone disease is increasing,
although it
remains higher in men than in women when matched for age. While still
somewhat controversial, several studies have reported an association
between renal stone disease and hypertension, but this may be confounded
by a shared link with obesity. However, independent of obesity, hyperoxaluria
has been shown to be associated with hypertension in stone-formers,
and the most common type of renal stone is composed of calcium oxalate.
The chloride–oxalate exchanger slc26a6 (also known as CFEX
or PAT-1), located in the renal proximal tubule, was originally thought
to have an important role in sodium homeostasis and thereby blood
pressure control, but it has recently been shown to have a key function
in oxalate balance by mediating oxalate secretion in the gut. We have
applied two orthogonal analytical platforms (NMR spectroscopy and
capillary electrophoresis with UV detection) in parallel to characterize
the urinary metabolic signatures related to the loss of the renal
chloride–oxalate exchanger in slc26a6 null mice. Clear metabolic
differentiation between the urinary profiles of the slc26a6 null and
the wild type mice were observed using both methods, with the combination
of NMR and CE-UV providing extensive coverage of the urinary metabolome.
Key discriminating metabolites included oxalate, m-hydroxyphenylpropionylsulfate (m-HPPS), trimethylamine-N-oxide, glycolate and scyllo-inositol
(higher in slc26a6 null mice) and hippurate, taurine, trimethylamine,
and citrate (lower in slc26a6 null mice). In addition to the reduced
efficiency of anion transport, several of these metabolites (hippurate, m-HPPS, methylamines) reflect alteration in gut microbial
cometabolic activities. Gender-related metabotypes were also observed
in both wild type and slc26a6 null groups. Urinary metabolites that showed a sex-specific pattern included trimethylamine, trimethylamine-N-oxide, citrate, spermidine, guanidinoacetate, and 2-oxoisocaproate.
The gender-dependent metabolic expression of the consequences of slc26a6
deletion might have relevance to the difference in prevalence of renal
stone formation in men and women. The different composition of microbial metabolites in the slc26a6 null mice is consistent with the fact that the slc26a6 transporter
is found in a range of tissues, including the kidney and intestine,
and provides further evidence for the “long reach” of
the microbiota in physiological and pathological processes
Construction and Standardization of Mathematics Achievement Test for IX<sup>th</sup> Grade Students
No full textEmotional intelligence as a mediator between leadership styles and leadership effectiveness: A theoretical framework
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