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[Stammbuch Mahlchen Merkel]
No full text[STAMMBUCH MAHLCHEN MERKEL]
[Stammbuch Mahlchen Merkel] (1)
Cover (1)
Titelblatt (8)
Einträge Bl. 2 - 191 (9
Merkel
No full textPlat of the town of Merkel, Texas which appears to have been part of a survey for the Texas & Pacific Railway Company. The various blocks of the town are divided to show the property lines. A legal statement at the top of the page asserts that the map is an accurate representation of the town and is signed by the land commissioner for the railway company. An inset in the upper-left corner shows the Grimes County School land. The map appears to have been sketched on a page from a ledger. Scale 1:3,600 (This map, Scale 1"=300', Drawn on Record 1"=200'
Merkel, Werner an Agnes Oestreich (1 Brief)
No full textMERKEL, WERNER AN AGNES OESTREICH (1 BRIEF)
Merkel, Werner an Agnes Oestreich (1 Brief) ( -
[Stammbuch Johann Friedrich Merkel] / Joh. Friedr. Merckell
Get PDF[STAMMBUCH JOHANN FRIEDRICH MERKEL] / JOH. FRIEDR. MERCKELL
[Stammbuch Johann Friedrich Merkel] / Joh. Friedr. Merckell (1)
Cover (1)
Besitzvermerk (9)
Eintrag Bl. 2v (10)
Einträge Bl. 8 - 20 (13)
Einträge Bl. 21 - 60 (26)
Einträge Bl. 61 - 82 (56
Dissociation, quantification and culture of normal human merkel cells among epidermal cell populations derived from glabrous and hairy skin sites
No full textMerkel cells constitute a unique population that remains difficult to characterize in human skin because of their scarcity. Our aim was to develop tools for the study of Merkel cells in vitro. As a first step, we evaluated the possibility of harvesting human Merkel cells with the two-step extraction method that is widely used to extract and culture keratinocytes. Merkel cells were identified in the epithelial portion of hairy or glabrous skin biopsies by keratin (K)18 and K20 labeling. The totality of cutaneous epithelial cells were isolated from either hairy or glabrous skin biopsies following enzymatic dissociation of both the epidermis and the hair follicles. Flow cytometry was performed to quantify the small Merkel cell population. The analysis revealed that K18-labeled cells represented between 4.0 and 7.6% of freshly dissociated basal epidermal cells. No significant differences were seen between samples derived from glabrous palmar and hairy anatomic sites from children and adults, respectively. We also reported on the presence of Merkel cells in primary and first subcultures of human epidermal cells. The next step will be to enrich the isolated human Merkel cells and improve their culture conditions. An amplification of the number of Merkel cells will allow further studies to unravel long-standing questions regarding their origin, proliferative capacity, and functions in cutaneous biolog
Brief von Jacob Grimm an Paul Johannes Merkel
No full textBRIEF VON JACOB GRIMM AN PAUL JOHANNES MERKEL
Brief von Jacob Grimm an Paul Johannes Merkel ( -
Merkel, [Paul Johannes] an Dorothea Grimm (1 Brief)
No full textMERKEL, [PAUL JOHANNES] AN DOROTHEA GRIMM (1 BRIEF)
Merkel, [Paul Johannes] an Dorothea Grimm (1 Brief) (Br 3894)
Brief 3894 (Br 3894
Power is draining away from Chancellor Merkel
Get PDFAngela Merkel managed to secure a fourth term in the 2017 German federal election, but she has faced increasing domestic pressure over recent months. John Ryan writes that the fourth term did not end well for previous German Chancellors Konrad Adenauer and Helmut Kohl, and history appears to be repeating itself for Merkel
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Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells
Get PDFWidera D, Hauser S, Kaltschmidt C, Kaltschmidt B. Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells. Anatomy Research International. 2012;2012:1-9.Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells
Expression of developmentally regulated transcription factors in Merkel cell carcinoma
No full textWe have examined a number of developmentally regulated transcription factors for expression in Merkel cells and MCC cell lines and demonstrated that their expression patterns may be prognostic in MCC. We have shown that human Merkel cells from adult scalp hair follicle and from neonatal foreskin epidermal sheets express Brn-3c and HATH1. In addition, results demonstrate that the novel Merkel binding activity complex MNF contains Brn-3c. Moreover, Classic lines which retain neuroendocrine phenotype, are slow growing in culture, grow in suspension and are thought to be less aggressive, retain Brn-2, Brn-3c and HATH1 expression, whereas Variant suspension lines which no longer express NE markers retain Brn-2 and Brn-3c expression, but lack HATH1. Further, Type IV Variant lines which grow as adherent monolayers have shorter doubling times, are more radiation- resistant and have higher cloning efficiencies in soft agar, all thought to be indicative of aggressive tumours, have reduced or no Brn-2 proteins and lack expression of Brn-3c and HATH1 transcription factors.No Full Tex
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