1,720,993 research outputs found
Manning (A. F.) - de Vroede (M.). Spectrum atlas van historische plaatsen in de Lage Landen
No full textWirtz Charles. Manning (A. F.) - de Vroede (M.). Spectrum atlas van historische plaatsen in de Lage Landen. In: Revue belge de philologie et d'histoire, tome 63, fasc. 4, 1985. Histoire médiévale, moderne et contemporaine. p. 907
De Vroede (M.) éd. Arbeid en onderwijs in België en Nederland in de 19de en 20ste eeuw (Mededelingen tijdens het colloquium, te Leuven gehouden op 21 november 1981).
No full textScholliers Peter. De Vroede (M.) éd. Arbeid en onderwijs in België en Nederland in de 19de en 20ste eeuw (Mededelingen tijdens het colloquium, te Leuven gehouden op 21 november 1981). . In: Revue belge de philologie et d'histoire, tome 66, fasc. 4, 1988. Histoire - Geschiedenis. p. 925
De Vroede (M.) et coll., Bijdragen tot de geschiedenis van het pedagogische leven in België dl III, De periodieken 1896-1914, 1ste stuk
No full textGubin Eliane. De Vroede (M.) et coll., Bijdragen tot de geschiedenis van het pedagogische leven in België dl III, De periodieken 1896-1914, 1ste stuk. In: Revue belge de philologie et d'histoire, tome 57, fasc. 3, 1979. Langues et littératures modernes — Moderne taal- en letterkunde. pp. 753-755
De Vroede (M.) et coll., Bijdragen tot de geschiedenis van het pedagogische leven in België dl III, De periodieken 1896-1914, 1ste stuk
No full textGubin Eliane. De Vroede (M.) et coll., Bijdragen tot de geschiedenis van het pedagogische leven in België dl III, De periodieken 1896-1914, 1ste stuk. In: Revue belge de philologie et d'histoire, tome 57, fasc. 3, 1979. Langues et littératures modernes — Moderne taal- en letterkunde. pp. 753-755
Characterization of a novel loss-of-function mutation of PAX8 associated with congenital hypothyroidism.
No full textBackground Congenital hypothyroidism (CH) is a common endocrine disease that occurs in about 1:3000 newborns. In 80–85% of the cases, CH is presumably secondary to thyroid dysgenesis (TD), a defect in the organogenesis of the gland leading to an ectopic (30–45%), absent (agenesis, 35–40%) or hypoplastic (5%) thyroid gland. The pathogenesis of TD is still largely unknown. Most cases of TD are sporadic, although familial occurrences have occasionally been described. Recently, mutations in the PAX8 transcription factor have been identified in patients with TD.
Objective Our aim was to identify and functionally characterize novel PAX8 mutations with autosomal dominant transmission responsible for TD.
Design The PAX8 gene was sequenced in a mother and child both suffering from congenital hypothyroidism (CH) because of thyroid hypoplasia. Subsequently, expression vectors encoding the mutated PAX8 were generated, and the effects of the mutation on both the DNA-binding capability and the transcriptional activity were evaluated.
Results PAX8 gene sequencing revealed a heterozygous mutation that consists of the substitution of a histidine residue with a glutamine at position 55 of the PAX8 protein (H55Q). When tested in cotransfection experiments with a thyroglobulin promoter reporter construct, the mutant protein turned out to be still able to bind DNA in Electrophoretic Mobility Shift Assay assays but transcriptionally inactive.
Conclusions Our findings confirm the important role of PAX8 in normal thyroid development and support the evidence that in humans haploinsufficiency of PAX8 is associated with TD
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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