1,721,029 research outputs found
Reformulation of a phenomenological model for symmetric rate-independent hysteresis
No full textThe present paper enhances, both theoretically and numerically, a recent uniaxial phenomenological model aiming to reproduce complex hysteretic behaviors of seismic isolation devices, including steel- and fiber-reinforced elastomeric bearings, presenting smooth hysteresis loops with hardening and/or softening regions. The investigated constitutive model is based on five parameters that can be directly related to the experimentally observed hysteresis loops. Moreover, because of its analytical nature, the presented formulation is capable of computing in closed form the generalized response relevant to any displacement increment starting from a known equilibrium state. Hence, differently from the original differential formulation of the investigated model as well as from popular materials such as the celebrated Bouc–Wen, the presented formulation does not require any iterative strategy for computing the hysteretic force. Finally, the investigated model is validated by numerical simulations compared with experimental tests selected from the literature
Hypnotic Effects of Melatonergic Compounds Measured in Mice or Rats
No full textMelatonin is a pleiotropic compound mostly acting through its two G protein-coupled receptors named MT1 and MT2 and known for its role in regulating the sleep/wake cycle and circadian rhythms. Although this is common belief, there has been long debate in the scientific community on whether melatonin or melatonergic compounds are endowed with hypnotic effects. One of the reasons for this debate relied on contrasting findings in the literature in part due to non-standardized methods across studies in examining at preclinical level the effect of melatonin or melatonergic compounds on the sleep/wake cycle. Here, we describe a method in mice and rats to evaluate the effect of melatonin or melatonergic compounds on the different stages of the sleep/wake cycle, providing details concerning the administration of the drug and the analytical procedure for scoring the electroencephalogram/electromyogram (EEG/EMG) recording
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Design and evaluation of a factorization-based grasp myoelectric control founded on synergies
No full textIn this article we present a factorization-based myoelectric proportional control that uses surface skin electromyographic (sEMG) measurements to estimate the hand closure level of a user for telemanipulation purposes. The sEMG-based proportional control design is presented and the results of an experimental session are reported. In particular, involving one healthy subject, four different factorization algorithms are tested (Factor Analysis, Fast Independent Component Analysis, Non-negative Matrix Factorization and Principal Component Analysis) and quantitative evaluated along four different daily session using four different error metrics (Root-Mean-Square Error, Normalized Root-Mean-Square Error, cross-correlation coefficient and Dynamic Time Warping measurement). The metrics are computed comparing the sEMG-based estimation of the hand closure level with a ground-truth signal obtained through a motion tracking system. The results report for better performances of the Non-negative Matrix Factorization algorithm, that can be used for controlling robotic hands in a real telemanipulation scenario. Therefore, the proposed myoelectric proportional control was finally tested in a simple validation grasping scenario using a real robotic hand, reporting for user's simplicity and intuitiveness in regulating the grasp closure in accordance with different objects
D-Lysergic Acid Diethylamide (LSD) as a model of psychosis: Mechanism of action and pharmacology
Full text linkD-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD. We searched Pubmed, Web of Science, Scopus, Google Scholar and articles’ reference lists for preclinical studies regarding the mechanism of action involved in the psychotic-like effects induced by LSD. LSD’s mechanism of action is pleiotropic, primarily mediated by the serotonergic system in the Dorsal Raphe, binding the 5-HT2A receptor as a partial agonist and 5-HT1A as an agonist. LSD also modulates the Ventral Tegmental Area, at higher doses, by stimulating dopamine D2, Trace Amine Associate receptor 1 (TAAR1) and 5-HT2A. More studies clarifying the mechanism of action of the psychotic-like symptoms or psychosis induced by LSD in humans are needed. LSD’s effects are mediated by a pleiotropic mechanism involving serotonergic, dopaminergic, and glutamatergic neurotransmission. Thus, the LSD-induced psychosis is a useful model to test the therapeutic efficacy of potential novel antipsychotic drugs, particularly drugs with dual serotonergic and dopaminergic (DA) mechanism or acting on TAAR1 receptors
Effective deployment of CNNs for 3DOF pose estimation and grasping in industrial settings
Full text linkIn this paper we investigate how to effectively deploy deep learning in practical industrial settings, such as robotic grasping applications. When a deep-learning based solution is proposed, usually lacks of any simple method to generate the training data. In the industrial field, where automation is the main goal, not bridging this gap is one of the main reasons why deep learning is not as widespread as it is in the academic world. For this reason, in this work we developed a system composed by a 3-DoF Pose Estimator based on Convolutional Neural Networks (CNNs) and an effective procedure to gather massive amounts of training images in the field with minimal human intervention. By automating the labeling stage, we also obtain very robust systems suitable for production-level usage. An open source implementation of our solution is provided, alongside with the dataset used for the experimental evaluation
Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder
No full textRecent clinical and preclinical evidence points towards empathogenic and prosocial effects elicited by psychedelic compounds, notably the serotonin 5-HT2A agonists lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), and their derivatives. These findings suggest a therapeutic potential of psychedelic compounds for some of the behavioural traits associated with autism spectrum disorder (ASD), a neurodevelopmental condition characterized by atypical social behaviour. In this review, we highlight evidence suggesting that psychedelics may potentially ameliorate some of the behavioural atypicalities of ASD, including reduced social behaviour and highly co-occurring anxiety and depression. Next, we discuss dysregulated neurobiological systems in ASD and how they may underlie or potentially limit the therapeutic effects of psychedelics. These phenomena include: 1) synaptic function, 2) serotonergic signaling, 3) prefrontal cortex activity, and 4) thalamocortical signaling. Lastly, we discuss clinical studies from the 1960s and 70s that assessed the use of psychedelics in the treatment of children with ASD. We highlight the positive behavioural outcomes of these studies, including enhanced mood and social behaviour, as well as the adverse effects of these trials, including increases in aggressive behaviour and dissociative and psychotic states. Despite preliminary evidence, further studies are needed to determine whether the benefits of psychedelic treatment in ASD outweigh the risks associated with the use of these compounds in this population, and if the 5-HT2A receptor may represent a target for social-behavioural disorders
Caesar II: An Italian decision support tool for the seismic risk. The case study of Torre Pellice, Villar Pellice and Pinerolo municipalities
Full text linkItaly is a country with high seismic risk; however, a broad seismic classification of the national territory has been introduced only in the last twenty years. Therefore, most of the existing buildings stock do not comply with the current anti-seismic codes. In recent years, the seismic events that occurred in Italy have highlighted the complexity of emergency management and the great challenge for public authorities called to answer to the post-event reconstruction and the planning of effective risk prevention and mitigation measures implemented in "peacetime". In this perspective, the CAESAR II project (Controlling, Mitigating and Managing Earthquake Emergency: Cost-Benefit and Multi-criteria Analysis of Impact Scenarios for Risk Reduction and Increased Resilience) has been developed as a decision support system for public authorities engaged in the development of seismic disaster risk reduction plans. CAESAR II includes a module for the simulation of retrofitting measures applied at the municipal scale, integrating different categories of anti-seismic and energy improvement measures based on the vulnerability analysis of the existing buildings stock. The CAESAR II tool's core is the module for evaluating "seismic impact scenarios" based on the end-users' hazard. The output of the model includes information on expected damage levels for buildings (from D0-no damage to D5- total collapse) and population (dead, injured and homeless). Impact scenarios can be customised according to the minimum unit of analysis assumed (municipality or 250x250m square mesh grid) and the availability of exposure data (from national census data or survey on the spot building by building according to the PLINIVS form). Scenarios include geo-referenced data managed by geo-servers to exchange data in a format compliant with OGC (Open Gis Consortium) standards and the European INSPIRE Directive. Simulation results can be further processed through the Multi-Criteria and Cost-Benefit Analysis modules to support the comparative assessment of alternative seismic and energy measurements. In this work, the procedures included in CAESAR II are described and a case study is reported. It concerns the analysis of the expected damage assessment on buildings and population for three municipalities in northern Italy, Torre Pellice, Villar Pellice and Pinerolo (Piedmont Region)
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