7,311 research outputs found
A problematic zygopleuroid gastropod Acanthostrophia revisited
No full textSEM examination of the type series of Acathostrophia acanthica CONTI & FISCHER, 1984 from Middle Jurassic of Italy has shown that this gastropod most likely belongs to the family Protorculidae as previously suggested by NÜTZEL (1998). It is also similar to some Jurassic species of Polygyrinidae, which might also be related to Protorculidae. The supposition of KAIM et al. (2008) that Acanthostrophia is an early member of Abyssochrysidae could not be confirmed
La Corte dei conti
No full textTrattasi del codice commentato del complesso e complessivo ordinamento della Contabilità pubblica. In particolare il capitolo curato da De Benetti affronta il profilo strutturale della Corte dei conti
The radical right in Europe, between slogans and voting behavior. IHS Political Science Series No. 123, July 2011
No full textThe paper analyzes the radical right‘s attitudes toward the EU focusing in particular on the level of congruence between the programmatic statements of the central office and the voting behavior of their MEPs. It shows that although radical right parties represent a source of opposition to the EU, within the EP they express their dissent making use of the rules of the game, voting with the opposition more than the other forces do, but voting almost as much with the majority. The party public office in the EP is inserted in the legislative process and even more collusive with the other parties of both sides of the political spectrum than the Eurosceptical rhetoric and statements of central office makes the public believe
Large effects of land use conversion on C storage in dry forest ecosystems from Southern South America
No full textFil: Conti, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Conti, Georgina. Universidad Nacional de Córdoba; Argentina.Net CO2 land use change emissions represent one of the main drivers of global climatic change. However, the effect of the accelerated deforestation over plant and soil carbon (C) pools from dry Chaco forests from southern South America has been poorly quantified. Including five ecosystem types related to different land uses, we quantified the magnitude and change of total C stocks (including trees, shrubs, herbs, coarse and fine debris, soil organic and inorganic C stocks up to 2 m depth). C stocks in soils represented the largest C stocks in these forest ecosystems (more than 74%), and specifically C stored at deeper layers. Shrubs also comprises a large C stocks not quantified before in detail. The conversion of primary and secondary forest to degraded shrublands and croplands did generate high losses of organic C both in aboveground biomass and in soils up to 30 cm depth with values of c. 45.6 % of C loss. Although deeper soil C is in general stable, land use conversion did also imply changes in soil inorganic C (27.63 Mg C ha-1 of net C loss). Our results indicate that a landscape transformation as the one predicted in the region may lead to a huge reduction of the C stored in these forest, with a consequent net C emission and a reduction in the associated ecosystem services provided to local, regional and global scales by dry Chaco forests.https://scisoc.confex.com/scisoc/2014SES/webprogram/Person510967.htmlFil: Conti, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Conti, Georgina. Universidad Nacional de Córdoba; Argentina.Ecologí
Design, synthesis and biological characterization of PfGAPDH inhibitors
No full textMalaria has a tremendous health, social and economic impact on people living in tropical and subtropical regions of the world. WHO estimated 214 million cases and 438 000 deaths in 2015 and 3.2 billion people are globally at risk of infection1. Available treatments are becoming progressively less effective, mainly because parasites are constantly acquiring resistance toward the drug in use. Therefore, there is an urgent need of developing therapeutic agents acting on new targets.
Plasmodium parasites (P. falciparum is the most lethal), in their amastigote phase, produce energy only through glycolysis. In this pathway, GAPDH catalyses the first energy productive step and thus represent a valuable target for drug discovery. Known GAPDH inhibitors that bind to the active site are small nonselective molecules (iodoacetamide, 3-bromopyruvate), which irreversibly react with cysteine residues of the enzyme, including the catalytic one. We designed and synthesized the first series of inhibitors characterized by a 3-bromoisoxazoline warhead2, inspired by 3-bromoacivicin, a known inhibitor of reactive cysteine containing enzymes3. The compounds were assayed for the inhibitory activity on the P. falciparum isolated enzyme showing a biphasic irreversible inactivation. MS/MS studies of the digested protein demonstrated the mild reactivity of the exploited warhead, which only reacts with catalytic Cys (activated by a His residues). The human ortholog of GAPDH is only partially inhibited (up to 25%). We explained this through a negative cooperativity that prevents the alkylation of all the four monomers of hGAPDH, resulting in selectivity among the two isoforms of GAPDH4. Compounds were also assayed on cultures of the bloodstream form of P. falciparum and human cell lines in order to determine their in vitro antiparasitic activity and toxicity.
The goal of this project is to obtain compounds with improved potency and pharmacokinetic properties, suitable for in vivo studies on animal model of P. falciparum infections.
1. http://www.who.int/mediacentre/factsheets/fs094/en/
2. Bruno, S.; Pinto, A.; Paredi, G.; Tamborini, L.; De Micheli, C.; La Petra, V.; Marinelli, L.; Novellino, E.; Conti, P.; Mozzarelli, A. J. Med. Chem. 2014, 57(17), 7465-7471.
3. a) Conti, P.; Pinto, A.; Wong, P.E.; Major, L.L.; Tamborini, L.; Iannuzzi M.C.; De Micheli, C.; Barrett, M.P.; Smith, T.K. ChemMedChem 2011, 6(2), 329-333. b) Tamborini, L.; Pinto, A.; Smith, T.K.; Major, L.L.; Iannuzzi, M.C.; Cosconati, S.; Marinelli, L.; Novellino, E.; Lo Presti, L.; Wong, P.E.; Barrett, M.P.; De Micheli, C.; Conti, P. ChemMedChem 2012, 7(9), 1623-1634.
4. Bruno, S.; Margiotta, M.; Pinto, A.; Cullia, G.; Conti, P.; De Micheli, C.; Mozzarelli, A. Bioorg. Med. Chem. 2016, 24(12), 2654-2659
C. Conti Rossini. Notice sur les manuscrits éthiopiens de la Collection d'Abbadie
No full textChabot Jean-Baptiste. C. Conti Rossini. Notice sur les manuscrits éthiopiens de la Collection d'Abbadie. In: Journal des savants. 17ᵉ année, Septembre-octobre 1919. p. 272
C. Conti Rossini. Notice sur les manuscrits éthiopiens de la Collection d'Abbadie
No full textChabot Jean-Baptiste. C. Conti Rossini. Notice sur les manuscrits éthiopiens de la Collection d'Abbadie. In: Journal des savants. 17ᵉ année, Septembre-octobre 1919. p. 272
C. Conti Rossini. Principi di diritto consuetudinario dell'Eritrea
No full textChabot Jean-Baptiste. C. Conti Rossini. Principi di diritto consuetudinario dell'Eritrea. In: Journal des savants. 15ᵉ année, Décembre 1917. pp. 561-563
C. Salotti, Il pensiero e l'anima di Augusto Conti
No full textGhio J. C. Salotti, Il pensiero e l'anima di Augusto Conti. In: Revue néo-scolastique. 12ᵉ année, n°47, 1905. pp. 401-402
C. Salotti, Il pensiero e l'anima di Augusto Conti
No full textGhio J. C. Salotti, Il pensiero e l'anima di Augusto Conti. In: Revue néo-scolastique. 12ᵉ année, n°47, 1905. pp. 401-402
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