86,599 research outputs found
Studio di Fase II con cisplatino e temozolomide in pazienti con glioblastoma pesantemente pretrattati e refrattari alla temozolomide
No full textAn update on targeted therapy in metastatic renal cell carcinoma
No full textAn improved understanding of the biological pathways deregulated in renal cell carcinoma has led to the development of various targeted agents, changing dramatically the therapeutic options for this disease. However, despite numerous opinions and guidelines, the optimal treatment still remains uncertain. In this review, we analyze the most recent published reports regarding the agents sunitinib, bevacizumab, sorafenib, temsirolimus, and everolimus. Moreover, we assess the novel targeted drugs pazopanib and axitinib. In addition, given the likely lack of cross-resistance between these targeting agents, we discuss sequential and combination targeted therapy in metastatic renal cell carcinoma, analyzing the most recent data
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Chronic anemia due to mitomycin C is drug dose-dependent, normocytic, progressive, related to erythropoietin levels and quantitatively predictable: implications for radiochemotherapy.
No full textMitomycin C (Me) is used as therapy against solid tumors, also combined with other chemotherapeutic agents or radiotherapy. It may cause acute, subacute, or chronic anemia capable of modifying the results of chemo- and radiotherapy. Erythropoietin may be lowered by cancer itself or because of chemoradiotherapy. There are few studies investigating the relationship between erythropoietin and chronic anemia. We prospectively analyzed the chronic anemia and erythropoietin in 38 patients with solid cancer. Patients were 40 to 82 years of age. MC was randomly given every 3 weeks as a single drug at 10 or 20 mg/m2• When myelotoxicity occurred the next therapy cycle was delayed until recovery. RBCindices, hemolysis, erythropoietin, liver and kidney function were studied. MCcycles were 136 (3.6 ± 1.4 per pt), 32 being delayed because of myelotoxicity. Hematocrit, hemoglobin and RBC were inversely related to the cumulative dose (r = 0.70 to 0.86; p 0.03 to 0.01) of MC. Other tests remained stable. Anemia occurred almost twofold earlier in the 20 mg/m2 group (p=0.049). Basal erythropoietin, already lower than in age and sex watched 81 non cancerous subjects (p<O.OOI),decreased during MCtherapy (p<O.OI). For each given MC mg/m2 a 0.0372 Hb mg/dl reduction occurred. Chronic anemia due to MCis accompanied by erythropoietin reduction. These results can help in designing chemoradiotherapy. © E.S.I.F.T. srl- Rrenze
Oxaliplatin induces a rise of topoisomerases in PBMC of 53 cancer patients
No full textleading to DNA adduct formation subsequently causing irreversible DNA replication error and apoptosis. Topoisomerase I and II (TPs) are critical enzymes for DNA function and cell survival. They control maintaining and modifying DNA topology
during both replication and translation of genetic material, and restore DNA toxicity exerted by Platins. TPs-inhibitors drugs are largely used in chemotherapy, however, most often blindly of both the cancer tissue and the PBMC TPs status.
Aim of the study: To evaluate the PBMC-TPs behaviour after OXP, and OXP followed by CPT11 administration.
Patients and methods: Patients were 53 (23 F, 30 M; 37 to 80 years old, median age 65 years) with colon-rectal (29), lung (7), ovary and gastric (4 each), miscellaneous (9). TPI, IIa and IIb measurement was made by quantitative real-times RT-PCR. Test was made basally and after 1, 2, 3, 4, 5 hours after OXP (1 hr iv infusion) and also when OXP was followed by the administration of TPs inhibitor drug Irinotecan (CPT11; 1 hr-iv infusion).
Results: After the OXP administration of a fast rise of TP I, IIa and IIb mRNA expression occurs (increment median percentage: 502%, 59,1% and 361%, respectively; p> 0.0001). 14 day after in the same patient, the CPT11 (sequentially given after OXP) markedly reduced the previously observed TPs rising (p> 0.0001).
Conclusions: The timing of the TPs increase caused by OXP is rapid and it is cancelled by CPT11. Present results may help in constructing a combination chemotherapy regimen. The study is ongoing to enrol further patients.
Present work is a part of the study program, and partly supports by AOI (Associazione Oncologica Italiana), and by Regione Veneto (N. 204/2004)
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Cilengitide in bevacizumab-refractory high-grade glioma: Two case reports and critical review of the literature
No full textHigh-grade gliomas (HGG) are aggressive and highly vascularized brain tumours. Despite multimodality therapy including surgery, radiation therapy and in many cases temozolomide chemotherapy, the prognosis is dismal. Salvage therapies following progression after radiation therapy and chemotherapy have historically yielded disappointing results. Bevacizumab is an interesting antiangiogenic drug used as a second-line treatment but although most patients benefit, essentially all patients ultimately progress. Moreover, some clinical studies have documented low activity of a second attempt at vascular endothelial growth factor pathway inhibition after failure of a first. The use of another drug with a different angiogenic pathway inhibition may probably result in a higher activity. Here, we describe, to our knowledge for the first time, the activity and safety of cilengitide, an agent with a different antiangiogenic and anti-invasive activity, administered in two bevacizumab-refractory patients with HGG. In addition, we present a rapid review of the activity of cilengitide in HGG. Anti-Cancer Drugs 23:749-753 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
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