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Identification of novel therapeutic approaches to selectively target senescent cells in prostate cancer
No full textIdentification of novel therapeutic targets to selectively eliminate senescent cells in prostate cancer.
No full textDespite recent progresses, prostate cancer (PC) is still the second most diagnosed cancer and the sixth leading cause of cancer death among men worldwide. Commonly used anticancer treatments to eradicate PC are based on chemotherapy and radiotherapy, with or without a castration-based strategy in which androgen deprivation is achieved by pharmacological or surgical castration. Efficacy of all these types of therapies also rely on their abilities to induces “premature” senescence, a cellular state characterized by the irreversible arrest of cell growth that affects both normal and cancer proliferating cells. However, despite the proliferation block, senescent cells remain metabolically and synthetically active: indeed, they release many cytokines and chemokines known as senescence-associated secretory phenotype (SASP) able to affect nearby cells. In particular conditions, SASP may promote cellular proliferation and angiogenesis thus inducing tumour progression and invasiveness. For this reason, elimination of senescent cells from tumours can avoid cancer metastasis and relapse. In our study, starting from a proteomic and bioinformatic analysis of FDG-based FACS-sorted PTEN null murine prostate tumour cells, we identify membrane proteins upregulated on senescent population that can be exploited as potential targets for the development of new therapeutic strategy for senescent cells clearance
Identification of novel therapeutic approaches to selectively target senescent cells in prostate cancer
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Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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