197,224 research outputs found
Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration
No full textLittle is known about the effects of cholesterol-lowering agents in hypercholesterolemic patients with primary biliary cirrhosis (PBC). The aim of this study was to compare the changes induced by simvastatin and ursodeoxycholic acid (UDCA) on cholesterol metabolism in patients with PBC and preserved liver function. Six patients with PBC were administered simvastatin (40 mg/day) for 30 days and, after a washout period of 30 days, ursodeoxycholic acid (600 mg/day) for 30 days. Serum levels of lathosterol, campesterol, 7 alpha-hydroxycholesterol, and 27-hydroxycholesterol were measured by gas chromatography-mass spectrometry. During simvastatin administration, reduction of cholesterol levels (34% in 30 days) was paralleled by the decrease of lathosterol (55%), whereas concentrations of campesterol and of the two hydroxysterols were not substantially modified. During ursodeoxycholic acid administration, a trend toward a decrease of serum cholesterol concentrations was observed after only one year of treatment, and these changes were paralleled by the decrease of campesterol serum levels. Both simvastatin and UDCA were well tolerated, and a reduction of serum liver enzyme levels occurred with the latter. Simvastatin proved to be safe and effective in reducing serum cholesterol levels in patients with PBC by an inhibitory effect on cholesterol synthesis occurring within 24 h. --Del Puppo, M., M. Galli Kienle, A. Crosignani, M. L. Petroni, B. Amati, M. Zuin, and M. Podda. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. J. Lipid Res. 2001. 42: 437--441
Effects of fenofibrate on biliary lipids and bile acid pool size in patients with type IV hyperlipoproteinemia
No full textLipid-lowering drugs, notably clofibrate, may induce a supersaturation of bile with cholesterol, thus favouring the development of cholelithiasis. In order to see whether or not fenofibrate, a clofibrate analogue, has any influence on biliary cholesterol saturation, we determined the lipid composition of gallbladder bile and the bile acid pool size in 15 patients with type IV hyperlipoproteinemia before and after 6-8 weeks of treatment with a daily dose of 300 mg of the drug. At the end of treatment plasma triglycerides were markedly decreased, whereas no detectable influence on liver cell integrity or bile excretory function could be demonstrated in any patient by comparing the pre- and post-treatment serum levels of liver enzymes, bilirubin and bile acids. The mean bile cholesterol saturation index did not significantly change and cholic acid was the only bile acid to increase significantly. In the 3 patients with an initial saturation index of less than 1, bile became supersaturated with cholesterol. However, in no case were the limits of the metastable phase for cholesterol solubility in bile exceeded. Though only long-term prospective studies may give a definitive answer about the lithogenic potential of fenofibrate, our data on gallbladder bile composition in patients with type IV hyperlipoproteinemia indicate that it is not very likely that fenofibrate administration will increase the risk of gallstone formation in severely hyperlipidemic patients
Experimental Investigation of Magnetohydrodynamic Instabilities in a Magneto-Plasma-Dynamic Thruster
No full textAn extensive experimental investigation has been carried out in order
to understand the role of magnetohydrodynamic (MHD) instabilities on the reduced
performance of Magneto-Plasma-Dynamic (MPD) thrusters when operating at high
current. MPDs are electromagnetic plasma accelerators, currently under investigation as a possible, high-power electric propulsion option for primary space missions, whose thrust efficiency is limited by the onset of critical regimes observed when the current rises beyond a threshold value. Recently, it has been found (Zuin M. et al.,Phys. Rev. Lett., 95 (2004) 225003) that in these devices large-scale MHD helical kink mode instabilities develop, with m/n = 1/1 azimuthal and axial periodicity, and that the critical current condition is well described by the Kruskal-Shafranov criterion. In this paper the spatial structure of the kink has been reconstructed by magnetic and electrostatic probes and the results of two photomultiplier arrays,
16 channels each, collecting total radiation in the range 350–850 nm, confirm the
helical structure of a kink with nonuniform pitch
Relatório de revisão por pares para: Diálogos entre educação, cidade e patrimônio: investigando produções científicas brasileiras
No full textRevisão por pares do artigo:
SOUZA, R. S. R. e; DINIZ, M. Diálogos entre educação, cidade e patrimônio: investigando produções científicas brasileiras. Educ. Form., Fortaleza, v. 7, p. e6779, 2022. DOI: 10.25053/redufor.v7i1.6779. Disponível em: https://revistas.uece.br/index.php/redufor/article/view/6779.
Como citar este relatório:
ZUIN, A. L. A.; GRACIOLI, F. R. Relatório de revisão por pares para: diálogos entre educação, cidade e patrimônio: investigando produções científicas brasileiras. Educ. Form., 2022, Zenodo. Disponível em: https://doi.org/10.5281/zenodo.6817649.
Revisado por:
Aparecida Luzia Alzira Zuin (Universidade Federal de Rondônia, Porto Velho, Rondônia, RR, Brasil)
Filipe Rafael Gracioli (Instituto do Patrimônio Histórico e Artístico Nacional, Rio de Janeiro, Rio de Janeiro, RJ, Brasil
Varicocele and adolescents: semen quality after 2 different laparoscopic procedures
No full textThe Author analyze their results in adolescent patients treated for idiophatic varicocel
Topology during magnetic reconnection events in RFX-mod
No full textThis paper is devoted to the characterization of magnetohydrodynamics (MHD) tearing modes causing plasma–wall interaction (PWI) in the
Reversed-Field eXperiment (RFX-mod) reversed-field pinch (RFP) device. We study an example of a magnetic reconnection event in a high
plasma current discharge. The PWI is measured via a fast camera looking at the graphite-covered inner wall, showing two separated footprints of neutral carbon radiation. A first, simple analysis shows that the phase-locking of m=1 tearing modes is the principal cause of
enhanced PWI, as it is well documented in literature. Many modes contribute to the phase-locking, actually more than those measured with
the magnetic sensors. A more refined analysis is based on calculation of the Connection Length to the wall and of the loss time of Maxwellian
ions via the Hamiltonian guiding center code ORBIT. This analysis confirms the importance of the m=1 phase-locking as a loss channel of
high-energy particles, which is the mechanism that dominates the PWI pattern, but an additional role of the m=0, n=7 mode is
highlighted, which is a new result for the RFP. The PWI mediated by the m=0 islands is milder, which is a good outlook for the RFX-mod2
upgraded device, currently in the assembly phase
Generation of a diagnostic bead assay for primary biliary cirrhosis
No full textOertelt-Prigione S, Selmi C, Zuin M, et al. Generation of a diagnostic bead assay for primary biliary cirrhosis. Digestive and Liver Disease. 2007;39(3): A5
Optimal Site for Proximal Optimization Technique in Complex Coronary Bifurcation Stenting: A Computational Fluid Dynamics Study
No full textBackground/purpose: The optimal position of the balloon distal radio-opaque marker during the post optimization technique (POT) remains debated. We analyzed three potential different balloon positions for the final POT in two different two-stenting techniques, to compare the hemodynamic effects in terms of wall shear stress (WSS) in patients with complex left main (LM) coronary bifurcation. Methods/materials: We reconstructed the patient-specific coronary bifurcation anatomy using the coronary computed tomography angiography (CCTA) data of 8 consecutive patients (6 males, mean age 68.2± 18.6 years) affected by complex LM bifurcation disease. Subsequently a virtual bench test was performed in each patient using two different double stenting techniques represented by the DK and Nano crush using the reconstruction of Orsiro stents (Biotronik IC, Bulack, Switzerland). Results: A significant reduction in the mean WSS values in all the lesion's sites was observed when the final POT was performed 1 mm distally the carina cut plane in both techniques. Moreover, a significant improvement in the mean WSS values of the entire SB (e.g. LCX) was obtained performing the POT 1 mm distally to the carina cut plane. The proximal POT resulted in larger area of lower WSS values at the carina using both the Nano crush and the DK crush techniques. Conclusions: In patients with complex LM bifurcation disease the use of a final POT performed 1 mm distally to the carina cut plane might results in more favorable WSS patterns (i.e. higher WSS values) along all stented segments and, especially, along the entire LCX lesions
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