4,644 research outputs found
Everolimus and Malignancy after Solid Organ Transplantation: A Clinical Update
Full text linkMalignancy after solid organ transplantation remains a major cause of posttransplant mortality. The mammalian target of rapamycin (mTOR) inhibitor class of immunosuppressants exerts various antioncogenic effects, and the mTOR inhibitor everolimus is licensed for the treatment of several solid cancers. In kidney transplantation, evidence from registry studies indicates a lower rate of de novo malignancy under mTOR inhibition, with some potentially supportive data from randomized trials of everolimus. Case reports and small single-center series have suggested that switch to everolimus may be beneficial following diagnosis of posttransplant malignancy, particularly for Kaposi’s sarcoma and nonmelanoma skin cancer, but prospective studies are lacking. A systematic review has shown mTOR inhibition to be associated with a significantly lower rate of hepatocellular carcinoma (HCC) recurrence versus standard calcineurin inhibitor therapy. One meta-analysis has concluded that patients with nontransplant HCC experience a low but significant survival benefit under everolimus monotherapy, so far unconfirmed in a transplant population. Data are limited in heart transplantation, although observational data and case reports have indicated that introduction of everolimus is helpful in reducing the recurrence of skin cancers. Overall, it can be concluded that, in certain settings, everolimus appears a promising option to lessen the toll of posttransplant malignancy
Stylos kai edraiōma tēs ekklēsias, sive, Dissertatio de iustificatione hominis
No full textquam ... sub praesidio ... Ioh. Henrici Heideggeri ... placido eruditorum examini subiicit Andreas Steinerus, Vitod. author & respondens, ad diem Octobris loco horisque solitisDiss. Hohe Schule Zürich, 167
Author: Andreas Johannis Prytz
No full textAn edition of the consecration sermons in Gothenburg Cathedral 1633 by Superintendent Andreas Johannis Prytz, with introductory comments. The first sermon deals with the need for Church buildings, the second with the consecration of a new Church
We must combine conservation of nature with benefits to society. Interview by Gaby Allheilig with Andreas Heinimann on IPBES' Global Assessment Report on Biodiversity and Ecosystem Services
No full textOn 6 May 2019, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) presented its report on the state of biodiversity and ecosystem services worldwide. The first such assessment since 2005, it concludes that biodiversity and ecosystem loss has reached the point where it threatens human well-being. The researchers involved recommend several urgent measures to political decision-makers. Andreas Heinimann of CDE was the one Swiss scientist who worked as a lead author on a chapter of the report
To athanaton tēs psychēs, sive, Dissertatio de animae immortalitate, ex naturae & sanae rationis lumine demonstrata
No full textquam ... sub praesidio ... Iohannis Lavateri ... publicae ac placidae disquisitioni submittit Andreas Steinerus, Vitod. author & respondens ...Dedikation an Johannes Lavater, Jacob Meyer, Joh. Jacob Schaedler und Jacob Hegner auf dem Titelbl. versoDiss. Hohe Schule Zürich, 167
Response of right ventricular function to prostaglandin E1 infusion predicts outcome for severe chronic heart failure patients awaiting urgent transplantation
No full textFamily Virtues and Social Critique: Andreas Latzko’s Anti-War Prose (1917-1918)
No full textBetween 1917 and 1918, the Austro-Hungarian author Andreas Latzko (1876-1943) wrote three separate publications against the Great War: Menschen im Krieg (1917), Friedensgericht (1918), and Der letzte Mann (published 1919). Literary historians tend to bypass these works, and the few who note them chiefly focus on the best-selling novella cycle Menschen im Krieg (1917). It is usually presented as an example of expressionist political prose, or as a mixture of social satire and aesthetic shock-tactics that chiefly remains indebted to realist traditions, albeit with occasional incursions into expressionistic styles..
Effectiveness of Prophylactic Human Cytomegalovirus Hyperimmunoglobulin in Preventing Cytomegalovirus Infection following Transplantation: A Systematic Review and Meta-Analysis
No full textCytomegalovirus (CMV) is a common infection occurring in patients undergoing solid organ transplantation (SOT) or hematopoietic stem cell transplantation (HSCT). CMV-specific hyperimmunoglobulin (CMVIG) has been used for the past four decades and is typically administered either prophylactically or pre-emptively. The present meta-analysis evaluated CMV infection rates in SOT patients who received prophylactic CMVIG. PubMed and the Cochrane Library were searched for studies published up to October 2021. The primary endpoint was CMV infection rate. Thirty-two SOT studies were identified (n = 1521 CMVIG-treated and n = 1196 controls). Prophylactic CMVIG treatment was often associated with a lower risk of CMV infection in transplant recipients. The average CMV infection rate was 35.8% (95% confidence interval [CI]: 33.4–38.2%) in patients treated prophylactically with CMVIG and 41.4% (95% CI: 38.6–44.2%) in the control group not receiving CMVIG (p = 0.003). Similar results were observed in analyses limited to publications evaluating currently available CMVIG products (Cytotect CP and Cytogam; p < 0.001). In combination with the established safety profile for CMVIG, these results suggest that prophylactic CMVIG treatment in patients undergoing solid organ transplantation may be beneficial, particularly in those at high risk of CMV infection or disease
Short laws for finite groups and residual finiteness growth
Full text link We prove that for every n ∈ N n \in \mathbb {N} and δ > 0 \delta >0 there exists a word w n ∈ F 2 w_n \in F_2 of length O ( n 2 / 3 log ( n ) 3 + δ ) O(n^{2/3} \log (n)^{3+\delta }) which is a law for every finite group of order at most n n . This improves upon the main result of Andreas Thom [Israel J. Math. 219 (2017), pp. 469–478] by the second named author. As an application we prove a new lower bound on the residual finiteness growth of non-abelian free groups. </p
Value quantification
No full textThis chapter explores the concept and practice of value quantification, emphasizing its crucial role in effectively communicating product offerings in industrial markets. Rather than relying solely on product characteristics, successful sales strategies involve translating unique selling points into quantifiable customer-specific economic value. The chapter synthesizes existing marketing and pricing literature, presenting a comprehensive model that categorizes benefits and sacrifices into quantitative and qualitative dimensions relevant to both B2B and B2C contexts. The author delineates a systematic approach for quantifying customer value, highlighting practical methodologies such as economic value analysis and conjoint analysis. Furthermore, the chapter underscores the managerial implications of value quantification, including enhanced pricing strategies, improved negotiation positions, reduced discounting, and performance-based pricing opportunities. Through detailed frameworks and real-world examples, the chapter provides actionable insights for effectively leveraging quantified value to gain competitive advantage and drive customer purchasing decisions
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