1,721,292 research outputs found
Managing governance adaptations in strategic alliances
No full textOne important question confronting firms engaged in a strategic alliance is how to adapt the relationship over time. This article identifies specific governance changes firms make in strategic alliances. Using illustrative data on strategic alliances in the biotechnology industry, the authors consider the frequency of governance adaptations and explore some of the factors affecting parent firms' interventions in their collaborative agreements. The data patterns demonstrate the relevance of parent firms' prior experiences with alliances as well as specific features of the alliance in influencing the likelihood and type of adjustments undertaken by parent firms. While alliance adaptation has previously been a black box in the alliance area, the article begins to specify some of the dimensions of alliance adaptation and their drivers
Glioblastoma stem cells differentiation through epigenetic modulation is driven by miR-296-5p/HMGA1/Sox2 axis
No full textGlioma Stem Cells (GSCs) biology is finely regulated by a cross-talk of epigenetic mechanisms of regulation and the action of Oct4/Sox2 stemness gene drivers. Recently, a novel mechanism of regulation of miRNA-296-5p/Sox2 axis together with a new gene target (HMGA1) was described. The results raised questions of great relevance in glioma therapy, especially for the failure of the current radio/chemotherapies. Can miR-296-5p/HMGA1/Sox2 axis trigger the differentiation of GSCs subpopulation? Can these findings be used in a short term to develop novel therapeutics to fight glioma? We thus believe that targeting HMGA1 in GSCs, via nano-liposomes miRNA delivery together with epigenetic drugs, could overcome the failure of the current therapies. Additionally, in silico analyses to identify other gene targets of miR-296-5p with data available in literature, found a remarkable association with new gene targets whose functions are related to cell differentiation processes. Taken altogether these findings make miR-296-5p an attractive target for human brain cancer treatment
A bird in the hand or two in the bush? Integration trade-offs in technology-grafting acquisitions
No full textTechnology-grafting acquisitions are the acquisitions of technology-based entrepreneurial firms by established firms. They are often motivated by the need to bring products speedily to market, as well as develop future product pipelines. We argue that these are conflicting objectives; a trade-off between short and long-term performance arises because acquisition integration has opposite effects on the strength of the organizational linkages between target and acquirer, and on the continued innovative capacity of the target firm. © 2003 Elsevier Science Ltd. All rights reserved
A behavioral perspective on the co-evolutionary dynamics of trust and governance in alliances
No full textWe propose a simulation model to explore the continuous dynamics of formal governance adaptations and trust in alliances. Surprisingly, the optimal reaction to negative performance signals is a strong formal governance enhancement, combined with a shift towards more balanced adjustments, pointing to the importance of adaptive capacities in strategic alliances
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Evaluation of cutaneous expression of PRUNE in the skin of normal dogs: a preliminary study: . In: Proceedings of 8th World Congress of Veterinary Dermatology.
No full textAppropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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