186,275 research outputs found
Fibroblast growth factor-2, chemo-resistance and colorectal cancer
No full textIntroduction:
The role of fibroblast growth factor-2 (FGF-2) on colorectal cancer (CRC) cells
exposed to chemotherapy has not been studied extensively. This thesis investigated
whether FGF-2 mediates chemoresistance in primary (SW480) and metastatic
(SW620) colon adenocarcinoma cell lines.
Methods:
Proliferation assays were used to assess the response of SW480 and SW620 colon
cancer cell lines to varying concentrations of FGF-2 and to optimise the dose of 5-
FU at which 50% cell death was observed. Cell survival assays were performed
following 96 hours exposure to 5-FU ± FGF-2. Levels of chemotherapy induced
apoptosis were determined using Caspase-3/7 assay. Expression of anti-apoptotic
proteins (Bcl-2 and Bcl-XL) and FGFRs at both protein and gene level were
determined to see if these contributed to the difference in chemoprotection observed. Results:
At 0.25 ng/ml, FGF-2 did not affect proliferation in either cell lines. 25μM of 5-FU
resulted in 50% kill in both cell lines. Significant cell survival was observed when
FGF-2 (0.25 ng/ml) pre-treated SW620 cells were exposed to 5-FU (25 μM)
compared to cells exposed to 5-FU alone (81% vs 60%, p=0.015). This
chemoresistance was associated with attenuation of cellular apoptosis (p=0.04) with
no significant change in expression of Bcl-2 and Bcl-XL at gene or protein level. This
survival advantage was not seen in SW480 cells (59% vs 55%, p=0.35). There were
no observed differences in the expression of FGFR1-4 in either cell lines.
Conclusion:
FGF-2 offers chemoresistance to SW620 and not to SW480 cells exposed to 5-FU.
Both cell lines expressed fgf2 and fgfr1-4 genes, suggesting that fgfr expression does
not account for the difference in chemoresistance. FGF-2 offered protection by
causing significant reduction in chemotherapy induced apoptosis in SW620 colon
cancer cell line; however this was not due to increased expression of anti-apoptotic
proteins. The molecular mechanisms for this selective chemoprotection need to be
investigated further
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Edward P. Wimberly, ITC, July 2011
No full textThis video is a conversation with Dr. Edward P. Wimberly. Dr. Wimberly talks about his book, "No Shame in Wesley's Gospel: A Twenty-First Century Pastoral Gospel". Brad Ost, AUC Woodruff Library, is the interviewer
Author Rights and Scholarly Publishing
No full textOriginally posted at
http://blog.library.gsu.edu/2014/10/24/author-rights-and-scholarly-publishing/</p
Mapping the Discipline of the Olympic Games An Author-Cocitation Analysis
No full textThe authors conducted an author cocitation analysis on prominent authors writing about the Olympics during the 1990s. Author cocitation is an established bibliometric technique that can be used to measure the relative similarities of topics written about by the cited authors. This enables a visual representation of the “intellectual space” of the discipline, in this case the Olympics, to be created for the period under review. So core and peripheral research areas are identified, along with their major contributors. The representation appears as a two-dimensional cluster-enhanced map. Subject expertise was then applied to the results to place labels on the generated clusters of authors and their topics
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
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