100,841 research outputs found
Wiosna/Lato/Jesien/Zima
No full textTheater poster for the play "Wiosna/Lato/Jesien/Zima (Spring/Summer/Fall/Winter)" features the text going up and down vertically around a green box, in which a chunky pair of scissors cuts a pencil drawing of upside-down irises.scissors on green backgroun
Venjamin F. Zima, La famine en URSS en 1946-1947 : origines et conséquences
No full textRittersporn Gábor T. Venjamin F. Zima, La famine en URSS en 1946-1947 : origines et conséquences. In: Annales. Histoire, Sciences Sociales. 52ᵉ année, N. 3, 1997. pp. 672-674
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Would the Members of the Society of X’s be Fond of Zima miejska?
No full textMickiewicz’s poetic debut Zima miejska (City Winter) coincides with the activity of the Society of X’s (Towarzystwo Iksów) from Warsaw, gathering representatives of the political and cultural elite of Congress Poland. They made a concerted attempt to fight for high quality of the repertoire and plays staged in the National Theatre, which was to be the beginning of a campaign to “increase” the cultural level of the society. Zima miejska represents classicistic descriptive poetics and as such would have found recognition in the eyes of the X’s. However, as a piece devoid of national values and avoiding didactics, a ludic and cosmopolitan piece, it would have been condemned. The only common ground between the Warsaw elite and the Vilnius Philomaths could have been, albeit poorly represented in research, the rococoesque aesthetics.Andrzej Fabianowski – prof. dr hab.; historyk literatury i krytyk literacki, badacz historii idei epoki romantyzmu, geografii humanistycznej, związków literatury współczesnej z tradycją romantyczną; pracuje w Instytucie Filologii Polskiej Uniwersytetu Warszawskiego; autor licznych artykułów naukowych oraz monografii, między innymi Paryż romantyków polskich (1999); Konwicki, Odojewski i romantycy (1999); Mickiewicz i świat żydowski (2018).Uniwersytet WarszawskiMickiewicz A., Dzieła. Wydanie Rocznicowe, t. 1–17, Warszawa 1998–2005.Poezya Filomatów, opr. J. Czubek, t. 1–2, Kraków 1922.Recenzje teatralne Towarzystwa Iksów 1815–1819, opr. J. Lipiński, Wrocław 1956.Borowy W., O poezji Mickiewicza, t. 1–2, Lublin 1958.Fabre J., Adam Mickiewicz i dziedzictwo oświecenia [w:] tegoż, Od oświecenia do romantyzmu, Warszawa 1995.Jędrzejewski T., „Zima miejska”. Mickiewicz w „czadzie uciech miejskich” [w:] Liryka Mickiewicza. Uczucia – świadectwa – ekspresje, red. A. Fabianowski, E. Hoffmann-
-Piotrowska, Warszawa 2018.Kostkiewiczowa T., Klasycyzm, sentymentalizm, rokoko, Warszawa 1975.Przychodniak Z., U progu romantyzmu. Przemiany warszawskiej krytyki teatralnej w latach 1815–1825, Wrocław 1991.Raszewski Z., Bogusławski, t. 1–2, Warszawa 2015.Rymkiewicz J.M., Siwicka D., Witkowska A., Zielińska M., Mickiewicz: Encyklopedia, Warszawa 2010.Seweryn D., „…jak tam zaszedłeś”. Mickiewicz w szkole klasycznej, Lublin 1997.Sudolski Z., Mickiewicz, Warszawa 2004.13915
IL-33/ST2L Pathway Dysregulation Promotes Cardiac Fibrotic Remodeling in Rat Animal Model of Obesity
No full textIntroduction: The IL-33/ST2L pathway exerts a fundamental protective role in cardiac tissue. It modulates the release of cytokines and mediators,
and the activation of mast cells in response to cellular stress or damage, protecting the heart from maladaptive remodeling. In the heart, IL-33 reduces fibrosis, inflammation, and infarct size, and increases cardiac
function and survival. Interestingly, IL-33/ST2L signaling is also related to fat deposition. On the other hand, the soluble form of ST2 receptor (sST2) is a decoy receptor, which blocks IL-33 signaling. Serum sST2 levels correlate to cardiovascular disease severity and represent an important clinical biomarker of heart failure. Here we assessed the IL-33/ST2 molecular pathway in a rat animal model of obesity to evaluate the role of fat accumulation in cardiac steatosis and fibrotic remodeling driven by IL-33/ST2 dysregulation. Methods: Twenty obese nondiabetic male Zucker rats (fa/fa-) and 10 lean littermates (Fa/+) were sacrificed at 25 weeks of
age according to Italian Ministry of Health Authorization (N°325/2015PR of 2015/04/05), and heart and serum were collected. Serum IL-33 and sST2 levels were assessed through ELISA (R&D system). Molecular and
Western blot analysis of IL-33 and ST2 were performed. Profibrotic signaling was evaluated by fibro-panel assay (Qiagen) on heart biopsies. Fibrosis deposition was evaluated on cardiac biopsies through Sirious Red and Western blot analysis of TGFβ and collagen 3 protein levels. Results: We showed that obesity determined a dysregulation of IL- 33/ST2 signaling characterized by a reduction of serum (p <0.05) andcardiac IL-33 (p = 0.05, and an increase of serum ST2 (p <0.05) in fat
animals compared to lean controls. We showed increased TGFβ (p <0.05) and collagen 3 (p = 0.05) protein levels in cardiac biopsies of fat animals, together with increased collagen fiber deposition (p <0.05 Sircol Red quantification). Fat animals presented an impaired remodeling profile with downregulation of Il1a (FC -2.39), Il4 (FC -2.04) mmp8 (FC2.93), and Pdgfb (FC -2.14), and an upregulation of genes Serpine 1 (FC 2.07), Smad4 (FC 5.78), and Thbs1 (FC 1.73), all involved on Tgfb signaling related to IL-33/ST2 impairment. Conclusions: We observed fibrotic remodeling of cardiac tissue and activation of pro-remodeling pathways in cardiac biopsies of fat animals, suggesting that obesity promotes cardiac remodeling through the loss of IL-33/ST2L cardioprotective pathway
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Mickiewicz’s Zima miejska in the Context of the Philomaths’ Anacreontics
No full textThe texts discusses Zima miejska (City Winter) by Adam Mickiewicz in the perspective of the modern version of anacreontic poetry. The poetic debut of Mickiewicz can be regarded not only as an example of a neoclassical-rococo poem delivering a joyful description of student amusements, but also as a step towards pre-bohemian aesthetics, which is characteristic of quite a number of verses written by the Philomaths around 1820. In the case of the Philomaths, the Bacchic motifs seem to be signs of a new approach to the process of writing poetry.Tekst powstał w ramach realizacji projektu „Kultura literacka polskiego rokoka lat 1795–1830 na tle europejskim”, zarejestrowanego pod numerem 2016/23/D/HS2/01119, finansowanego przez Narodowe Centrum Nauki.Tomasz Jędrzejewski – dr; historyk literatury pierwszej połowy XIX wieku; autor książek: Literatura w warszawskiej prasie kulturalnej pogranicza oświecenia i romantyzmu (Kraków 2016) oraz Czytanie „Dziadów” w czterech częściach (Warszawa 2018); kierownik projektu „Kultura literacka polskiego rokoka lat 1795–1830 na tle europejskim”, finansowanego przez Narodowe Centrum Nauki; adiunkt w Instytucie Literatury Polskiej Wydziału Polonistyki Uniwersytetu Warszawskiego.Uniwersytet WarszawskiJędrzejewski T., Mickiewicz w „czadzie uciech miejskich” [w:] Liryka Mickiewicza. Uczucia – świadectwa – ekspresje, red. A. Fabianowski, E. Hoffmann-Piotrowska,
Warszawa 2018.Kostkiewiczowa T., Klasycyzm, sentymentalizm, rokoko, Warszawa 1979.Krasowska P., Humor niechciany. Wczesna twórczość Mickiewicza w ujęciu dawnych badaczy, „Pamiętnik Literacki” 2009, z. 1.Libera L., „Wszyscy byli jak najzupełniej trzeźwi…” (O improwizacjach Mickiewicza) [w:] tegoż, Mickiewicz, Zielona Góra 2015.Mickiewicz A., Zima miejska, „Tygodnik Wileński” 1818, nr 125.Poezya filomatów, t. 1–2, oprac. J. Czubek, Kraków 1922.Rosenmeyer P.A., The Poetics of Imitation: Anacreon and the Anacreontic Tradition, Cambridge 1992.Seweryn D., „...jak tam zaszedłeś”. Mickiewicz w szkole klasycznej, Lublin 1997.Szastyńska-Siemion A., Poezja anakreontyczna w okresie oświecenia w Polsce, „Acta Universitatis Wratislaviensis. Classica Wratislaviensia” 1987, t. 11.Taylor A., Bacchus in Romantic England: Writers and Drink 1780–1830, London 1999.Tymowski K., Pieśń do porteru, „Pamiętnik Warszawski” 1816, t. 4.Wojda P., Cyganeria niecygańska – czyli o domniemanym buncie cyganerii warszawskiej [w:] Młody wiek XIX?, red. A. Rzepniewska, Warszawa 2019.15316
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