175,216 research outputs found
Business models for electric vehicles: Literature review and key insights
No full textIn many countries, the market for electric vehicles is not scaling up as expected despite huge public subsidies and technological progresses. One potential explanation is the absence of profitable business models that support commercialization and drive wide diffusion of electric vehicles. Business models that served conventional cars may not be appropriate for electric vehicles because of technological limitations such as shorter driving range and long charging cycles as well as higher acquisition cost. Recent years, however, have witnessed a growing body of scientific literature on electric vehicle business models. Nevertheless, the insights from this literature are fragmented and rarely address the business model with all its constituting elements. In this article, we review relevant literature on electric vehicle business models and distill key insights along each business model element. This way, our study provides a comprehensive and condensed overview of state-of-the-art research, while identifying potential directions for future research for scholars
Optimal uterine anatomy and physiology necessary for normal implantation and placentation.
No full textThe authors review aberrations of uterine anatomy and physiology affecting pregnancy outcomes with IVF. In the case of endometriosis and hydrosalpinx, pathologies outside of the uterus alter the uterine endometrium. In the case of endometriosis, Dominique de Ziegler outlines the numerous changes in gene expression and the central role of inflammation in causing progesterone resistance. With endometriosis, the absence of ovarian function inherent in deferred transfer, with or without a more lengthy suppression of ovarian function, appears to be sufficient to restore normal function of eutopic endometrium. Because laparoscopy is no longer routine in the evaluation of infertility, unrecognized endometriosis then becomes irrelevant in the context of assisted reproductive technology. With hydrosalpinx and submucus myomas, the implantation factor HOXA-10 is suppressed in the endometrium and, with myomas, even in areas of the uterus not directly affected. Daniela Galliano reviews various uterine pathologies, the most enigmatic being adenomyosis, where the endometrium also manifests many of the changes seen in endometriosis and deferred transfer with extended suppression appears to provide the best outcomes. Ettore Cicinelli's group has extensively studied the diagnosis and treatment of endometritis, and although more definitive diagnosis and care of this covert disorder may await techniques such as sequencing of the endometrial microbiome, it undoubtedly is an important factor in implantation failure, deserving our attention and treatment
The artificial womb
No full textAnn N Y Acad Sci. 2011 Mar;1221:124-8. doi: 10.1111/j.1749-6632.2011.05999.x.
The artificial womb.
Bulletti C1, Palagiano A, Pace C, Cerni A, Borini A, de Ziegler D.
Author information
Abstract
The availability of computer-controlled artificial hearts, kidneys, and lungs, as well as the possibility of implanting human embryos in ex vivo uterus models or an artificial endometrium, presents new perspectives for creating an artificial uterus. Survival rates have also improved, with fetuses surviving from as early as 24 weeks of gestation. These advances bring new opportunities for complete or partial ectogenesis through the creation of an artificial womb, one that could sustain the growth and development of fetuses outside of the human body.
© 2011 New York Academy of Sciences
Exploring the automotive transition: A technological and business model perspective
No full textThe automotive industry is currently undergoing a radical transition. This transition is a complex process that depends on many factors, especially technologies and business models. This process started many years ago, but it is still associated with a high uncertainty level. With regards to powertrain technologies, it is not clear which technology will be dominant in the future. Will it be the Battery Electric Vehicle (BEV) or the hydrogen-based Fuel Cell Electric Vehicle (FCEV) that will achieve a higher level of diffusion? Regarding business models, despite extensive research, the business models that will support the automotive transition are far from clear. Therefore, this research, based on a two-stage interview study, addresses both perspectives: technology and business model. Three possible options for powertrain technologies are identified: (i) coexistence of BEVs and FCEVs, (ii) BEVs, but conditional introduction of FCEVs, and (iii) BEVs only without FCEVs. In addition, the results show that business model innovation in the automotive industry can be driven by many aspects such as management vision, market, competition, future trends, battery, charging technology and infrastructure, as well as digital technologies and services. By combining the powertrain technology and business model dimensions, four future scenarios for the automotive transition are proposed: simply BEV, technology diversification, service-oriented BEV production, and maximum versatility. An expert evaluation allows the scenarios to be prioritized according to their likelihood of occurrence. The results show that the service-based BEV-scenario is the most likely one. Nevertheless, the differences between most and least likely scenarios are not large enough to disclose a clear trend, confirming the diffuse situation in the industry
Posen Januar 1945 Evakuierung u. Flucht d. dt. Zivilbevölkerung d. Stadt Posen im Jan. 1945
No full textMeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Deutschland 2000: Annahmen ueber zukuenftige Entwicklungen in Wirtschaft, Management, Marketing, Technologie, Gesellschaft
No full textSIGLEAvailable from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel C 175285 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Tabac, von dem gar heilsamen Wundtkraut Nicotiana oder Beinwelle : welchs Gott der Herr der Artzney und Kranckheiten vor etlich Jahren zu Nutz viler Krancknen auch in unsern Landen sehen lassen
No full textdurch Iacobum Zieglerum D. in etliche Formen der Artzney gebracht unnd an Tag gebenBogensignaturen: A-B⁴, C²Druckermark
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