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The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age.
No full textAging is commonly associated with immune
deficiency and dysregulation. The aging of
the immune system involves a progressive reduction
in naı ̈ve T cell output associated with thymic
involution and peripheral expansion of oligoclonal
memory T cells. We have investigated frequency,
phenotype, and function of CD3CD8CD28–
CD25 T cells in healthy volunteers over a wide
age range. We demonstrate that the frequency of
CD3CD8CD28–CD25 T cells in healthy volunteers
increases with age. Peripheral CD3CD8
CD28–CD25 T cells share phenotypic and functional
features with CD3CD4CD25 regulatory
T cells (Tregs): In particular, they strongly express
CTLA-4 and forkhead box P3. We observed that in
vitro, functional titration assays of CD3CD8
CD28–CD25 T cells show equivalent regulatory
function in young and elderly donors, with suppression
of proliferation and cytokine production in
response to polyclonal T cell stimulation. Finally,
CD3CD8CD28–CD25 T cells seem to specifically
express the CD122 receptor. Altogether,
these observations demonstrate an increase in peripheral
blood CD8 Tregs associated with aging.
J. Leukoc. Biol. 84: 000–000; 2008
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Co-culture of human keratinocytes and melanocytes: differentiated melanocytes are physiologically organized in the basal layer of the cultured epithelium.
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Secretion and binding of HMG1 protein to the external surface of the membrane are required for murine erythroleukemia cell differentiation
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