356 research outputs found
RETRACTED ARTICLE: Fluorescent labelling in living dental pulp stem cells by graphene oxide quantum dots
No full textWe, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article:Xincong Li, Haowei Guo, Shuangshuang Ren, Ruirui Fan, Yijun Yu, He Zhang, Chao Liu & Leiying Miao (2019) Fluorescent labelling in living dental pulp stem cells by graphene oxide quantum dots. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 115–122, DOI: 10.1080/21691401.2018.1544141Since publication, concerns have been raised about the integrity of the data and the methods presented in the article. When approached for an explanation, the authors have been unresponsive, and we have been unable to verify their original data. We are therefore retracting this article and the corresponding author listed in this publication has been informed.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”
Photothermally-Induced Molecular Self-Assembly of Macroscopic Peptide-Inorganic Hybrid Films
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We present a new strategy for a one-step preparation of macroscopic peptide-inorganic hybrid supramolecular films with functionality. It has been found that photothermal induction is of key importance to mediate the disassembly of supramolecular structures in solution phase, enrichment and reorganization at the interfaces associated with water evaporation. Incorporation of functional nanoscale objects into the film is achieved, providing the potential of integration of multiple functions. Texture and thickness of the hybrid film assembled at interfaces can be tuned and controlled by alteration of experimental parameters such as concentration and irradiation time. The photothermal treatment approach developed in this work is simple, flexible and controllable for design of macroscale functional supramolecular films, directly interfacing with biological systems. The photothermally-induced transformation of supramolecular structures is attractive for preparation of macroscale materials or devices towards a broad range of applications in biology and in nanotechnology.</p
Study on Improving English Reading Ability of the Electrical Automation Specialty Students in Multimedia-assisted Self-learning
No full textFor students majoring in Electrical Automation, reading is of vital importance in English learning process. In this paper, the author carries out tests, questionnaires and interviews and finally comes to the conclusion that multimedia-assisted self-learning has an effective impact upon students’ English reading ability. It makes students to be the key role of the learning procedure and makes them more active and more independent in English learning and is effective in improving their English reading ability
Ankle injury treatment and rehabilitation training in basketball option class
No full textAnkle injuries in basketball elective classes are one of the most critical sports injuries in basketball activities. This paper analyzes ankle injuries in basketball from the perspectives of biomechanics and human anatomy, investigates their specific causes, implements emergency treatment, and proposes scientific and effective methods for the rehabilitation training of ankle injuries, in order to better serve college students who are basketball enthusiasts
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells
No full textXiaolei Liang,1 Ruirui Wang,2 Wenshan Dou,3 Li Zhao,4 Lanxia Zhou,4 Junfang Zhu,4 Kairong Wang,5 Jiexi Yan4 1The Reproductive Medicine Special Hospital of the First Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China; 2The First Clinical Medical College, Lanzhou University, Lanzhou, China; 3The Second Clinical Medical College, Lanzhou University, Lanzhou, China; 4The Key Laboratory, The First Hospital of Lanzhou University, Lanzhou, China; 5School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, China Purpose: Due to the emergence of multidrug resistance (MDR), traditional antileukemia drugs no longer meet the treatment needs. Therefore, new antileukemia drugs with different action mechanisms are urgently needed to cope with this situation. Materials and methods: Arminin 1a-C is an antimicrobial peptide (AMP) developed from the ancient metazoan marine Hydra. In this study, we first explored its antileukemia activity. Results: Our results showed that Arminin 1a-C formed an α-helical structure and efficaciously suppressed the viability of leukemia cell lines whether or not they were multidrug resistant or sensitive, and there were no obvious differences between these cell lines. Arminin 1a-C exhibited distinct selectivity between noncancerous and cancerous cell lines. Arminin 1a-C interfered with K562/adriamycin (ADM) cell (a kind of multidrug-resistant leukemia cell line) proliferation in a very rapid manner and formed pores in its cell membrane, making it difficult to develop resistance against Arminin 1a-C. Conclusion: Our data show that Arminin 1a-C possesses great potential as a therapeutic candidate for the treatment of multidrug-resistant leukemia. Keywords: antimicrobial peptide, Arminin 1a-C, antileukemia, multidrug resistanc
Construction and self-assembly of beta-cyclodextrin derivative composite Langmuir films: Host-guest reaction and nanostructures
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The design and preparation of functional beta-cyclodextrin-based composite films are of key importance for wide application fields. This study demonstrates a new route to construct composite films by Langmuir-Blodgett (LB) method via cholesterol-modified beta-cyclodextrin derivative (CD-CHOL). The inclusion complex formation of CD-CHOL and azobenzene derivative (N-Azo) at the air/water interface was investigated. It has been found that the interfacial host-guest recognition could easily occur in the in situ formed CD-CHOL/N-Azo composite films and relatively difficult to occur in the ex situ immersed composite films, because there exist host-guest interaction as well as intermolecular hydrogen bonding interaction. The inclusion complex formation was confirmed by changes in the surface pressure-area isotherms, circular dichroism (CD) and UV-vis spectra of the transferred LB films. And the solvent effect of the composite CD-CHOL/N-Azo films was also investigated, indicating that host-guest interaction between N-Azo and CD-CHOL could occur rather in the nonpolar solvent than the polar solvent. The present research work about beta-cyclodextrin-based composite films by LB method may provide new exploration to prepare organized composite films and demonstrate potential applications in many fields.</p
Environmental themes in Chinese dance theater: experience and perspectives
No full textThis article highlights the involvement of Chinese dance theater in environmental protection. The author analyzes the ecological concepts of the work of three outstanding Chinese choreographers Yang Liping, Wang Yuanyuan, Tong Ruirui, whose works consistently embody the idea of the development of beautiful China, the ecological balance between human and nature, and the humankind’s adaptation to the new conditions of urban digital civilization. The purpose of the study is to investigate the existing experience of implementing Environmental themes in Chinese dance theater, as well as to outline the role of the Chinese ballet theater in the development of environmental consciousness. The research materials were the following stage works: “Pilgrimage to Lhasa”, “Two trees”, “Fire”, “Daughter of the country”, “Spirit of the Peacock”, “Romantic peacock”, “Echoes of Shangrila”, “Dynamic Yunnan”, “The Spirit of the Birds” (director and choreographer Yang Liping); “Haze” (director and choreographer Wang Yuanyuan); “Deep Memory”, “The World of Flowers”, “Then”, “The Earth”, “Goddess of Luo River”; ecological trilogy “Soaring Wings: Journey of the Crested Ibis”, “The Origin of the Big River”, “Deep AI You” (director and choreographer Tong Ruirui). The conclusions summarize the main characteristics of studied artists’ performances on environmental themes, as well as outline the prospects for further promotion of environmental awareness by means of dance theater. According to the author, the dance theater of China can continue to participate in environmental protection actively. The following forms of work turned out to be the most promising: further staging of choreographic performances on ecological topics, ecological production of the plays, open-air performances in natural areas and parks, original dance events in rural areas, choreographic open-air master classes, access to eco-responsible dance productions in online format, participation of ballet dancers in complex activities (ecological festivals, environmental photo sessions, media-programs or performances etc.)
Repeated application of a novel creatine cream improves muscular peak and average power in male subjects
No full textUsing a multicenter, randomized controlled trial, (N = 123, age 23 [+ or -] 4 years) we sought to determine whether administration of a novel, topical creatine supplement could improve muscular performance after acute and repeated (7-day) exposure. To study the acute performance enhancing effects of the supplement, subjects completed 5 sets of 15 maximal concentric single-leg knee extensions with and without the application of a low- (low dose [LD]-3.5 ml) or high-dose (high dose [HD]-7 ml) topical creatine cream. After a wash-out period, subjects had one leg randomized to receive either the creatine or placebo cream, with further randomization into an oral creatine or placebo supplement group. Subjects completed 5 sets of 15 maximal concentric single leg knee extensions before and after the supplementation protocol. After acute application, no significant differences in peak power (LD: 252 [+ or -] 93 W, HD: 261 [+ or -] 100 W, p = 0.21), average power (LD: 172 [+ or -] 65 W, HD: 177 [+ or -] 69 W, p = 0.78), or fatigue index (LD: 13.4 [+ or -] 10.6%, HD: 14 [+ or -] 11.9%, p = 0.79) were observed between experimental and placebo creams (peak power: LD: 244 [+ or -] 76 W, HD: 267 [+ or -] 109 W; average power: LD: 168 [+ or -] 57 W, HD: 177 [+ or -] 67 W; fatigue index: LD: 12.4 [+ or -] 9.6%, HD: 12.8 [+ or -] 10.6%) or when controlling for sex. After the 7-day supplementation protocol, a significant increase in average power (creatine: 203 [+ or -] 61-220 [+ or -] 65 W, placebo: 224 [+ or -] 61-214 [+ or -] 61 W) and peak power (creatine: 264 [+ or -] 73-281 [+ or -] 80 W, placebo: 286 [+ or -] 79-271 [+ or -] 73 W) in the leg receiving creatine cream was observed in male subjects. No differences were observed in female subjects. The topical creatine cream did not enhance measures of muscle performance after acute application, but was able to improve peak and average power in male subjects after 7 consecutive days of application
Zheng fu zu zhi de HPV mian yi zhuan an ke xing xing: Xianggang he Shenzhen de qian zhan xing zheng ce fen xi
No full textPh.D.Introduction: HPV vaccination for the prioritized group of adolescent girls is well accepted and implemented in developed countries as an effective measure for cervical cancer prevention and control with increasing population-level effectiveness evidence accumulated. The government has played a key role in achieving universal HPV vaccination of target girls for different levels of organization lead to variations in program implementation outcome. Therefore, HPV vaccination is worthy of being analyzed politically to assess the engagement of the government and other actors to generate evidence for this health initiative globally and nationally.General objective: When comparing Hong Kong and Shenzhen, the difference in political actions of the two governments that Hong Kong government’ commitment on underprivileged girls and allocating resources earlier than Shenzhen was identified with similar level of political priority and available technical evidence according to the criteria in the WHO position paper. Political feasibility has not been assessed in both settings, which may have contributed to relatively low level of political attention. This prospective policy analysis is an entry point to inform policy-making to achieve target girls’ universal coverage either from a partial program or no further actions taken by government.Methodology: Hong Kong and Shenzhen were selected as two cases to explore the feasibility of the policy change on HPV vaccination. Document review and in-depth interviews with identified stakeholders were conducted to obtain data. The framework of Health Policy Triangle was adapted to guide data collection and analysis in terms of context, actors, process and content. Specific approaches of stakeholder analysis examining actors’ position, power, role and interest in force-field mapping and thematic analysis focusing on data coding and theme development were used.Results: In Hong Kong, contextual influences included new government seeking proposals, political and health system and a mix of Chinese and Western values. Most professionals and non-governmental organizations had high level support but medium power. Legislative organization and bureaucracies had high power level but their positions were not high support. Mothers had low power for policy formulation and their position was between neutral and opposition. Themes for the policy process include problem definition of cervical cancer as a priority, perceptions on voluntary immunization, economic evaluation evidence, the political action of the Pilot Scheme and advocacy efforts for promotion in Hong Kong. Mixed results were identified on policy content designs.Shenzhen’s contextual factors were legislative authority under a unitary political system, economic developments and cultural values on immunization and sexuality. Stakeholders’ position and power could be explained by their role and interest in the Top-down health administration. A category of supporters including stakeholders from adult immunization clinic and community health centers and a gynecologist for cervical cancer treatment was identified having lower power. Mothers could be potential bystanders if having little knowledge on HPV vaccination. Additional themes generated were HPV vaccination related knowledge, vaccine approval and use procedures, domestic development and production, HPV vaccine demand and access, the role of media and political attention on evidence-informed policy-making in Shenzhen. These stakeholders also discussed different aspects of program planning prospectively.Discussions: In Hong Kong, different positions of stakeholders could be explained by their ethical stances and political reasons because HPV vaccination is becoming high politics. The degree of legitimacy of policy-making process ending up with a recommendation or statement was debated. Policy design should focus on reframing the issue in terms of arguing facts and values related to HPV vaccination. Although identifying policy entrepreneurs is of challenges, mobilizing relevant groups and individuals to build a coalition is recommended.Shenzhen witnesses a possibility of demonstration projects for local government’s horizontal accountability but no potential advocates were identified at local level for fragmented organization of public health facilities and health professionals’ lacking mobilization skills. A cervical cancer prevention expert could be a policy entrepreneur. Despite of these challenges, the recommendations include multi-participation to engage NGOs, suppliers and target girls and their mothers, power enforcement along governing system, as well as better use of media.Comparison: There are similarities in cultural value, technical issues and HPV vaccination policy-making rooting in internal and political dynamics of the two settings respectively. Identified differences of political and health care system, stakeholder constitution and engagement in policy-making as well as their power level, underlying values and ethical perspectives offer plausible explanations for cross-setting variations of feasibility. However, common policy strategies to enhance the feasibility include mixed approach of marketing and planning, moving the issue to legislative procedure and evidence-informed policy-making to achieve good governance.隨著人群水準效果證據的不斷累積，為青少年女性優先提供HPV 疫苗接種已經成為發達國家普遍接受並實施的子宮頸癌預防和控制的有效手段。不同的政府組織程度能引起專案實施結果的差異，因此政府在達成目標女孩全覆蓋上起重要作用。HPV 疫苗接種值得從政治角度來分析政府和其他利益相關者的參與，從而為這個健康倡議在國際上和國家層面創造證據。總目標：根據WHO立場檔中的標準，香港和深圳具有相似的政治優先順序和可使用的技術證據，但是兩個政府的政治行動卻不同，具體表現為香港政府致力於貧困的女孩並且比深圳政府更早地分配資源。在兩個城市政治可行性還未被研究過，這方面證據的缺乏可能也造成了相對低的政治關注。這個前瞻性的政策分析旨在為目標女孩全覆蓋的HPV疫苗接種提供政策制定的證據，無論從部分人群覆蓋還是沒有政府行動。研究方法：香港和深圳作為兩個案例來研究這個HPV疫苗接種政策的可行性。研究資料來源於文檔檢閱和對利益相關者的深度訪談。衛生政策三角理論用來在背景，利益相關者，政策過程和政策內容四個方面引導資料收集和分析。具體的方法有利益相關者分析，用於分析利益相關者的站位，權利，角色和利益，以及主題分析關注於資料編碼和主題形成。結果：在香港，背景影響因素包括新政府需求新方案，政治和衛生系統，以及中西方價值的融合。大多數專業人員和非政府組織強烈支援但是權力處於中間水準。立法組織和官僚機構雖然權力大但站位處於支持或中立。目標女孩的母親對於政策形成是低權力而她們的站位處於中立和反對之間。香港的政策制定過程中形成的主題有子宮頸癌防治優先順序的問題定義，對自願接種的看法，經濟學評估證據，實施先導計畫的政治行動以及推廣HPV免疫的宣導活動。對於政策設計，這些利益相關者有不同的看法。深圳的背景影響因素有統一政治體系下的立法權力，經濟發展和有關疫苗免疫和性方面的文化價值。在從上而下的衛生管理體系中，利益相關者的角色和利益能夠解釋他們的站位和權力水準。一組支持者包括成人接種門診和社區衛生服務中心的專業人員以及一名治療宮頸癌的婦科醫生擁有低權力水準，而對HPV疫苗接種瞭解很少的母親可能成為旁觀者。除了和香港重複的主題，深圳政策制定過程關注的主題還包括了HPV免疫相關知識，疫苗審批及使用程式，國內研發和生產，疫苗需求和接觸，媒體的角色以及對循證政策制定的政治關注度。這些利益相關者也前瞻性地討論了政策規劃的不同方面。討論：香港利益相關者的不同站位可以由他們的倫理立場以及政治原因來解釋，因為HPV疫苗接種正在成為高度政治化事件。無論以建議或聲明的形式，政策制定過程的合法性具有爭論性。政策設計應該關注在從辯論事實和價值觀兩方面進行重新構造這個問題。儘管確定政策宣導者充滿挑戰，給出的建議是動員相關的組織和個人來建立聯盟。因為地方政府橫向的責任，深圳見證了試點專案的可能性。但是由於分裂的公共衛生機構組織以及健康專業人士缺乏動員技能，沒有發現地方上的潛在宣導者。雖然有這些挑戰，建議有納入非政府組織，疫苗供應商和目標女生及其母親的多方參與，沿著治理體系的政策執行，以及更好地利用媒體。比較：兩個城市的相同之處包括了文化價值觀，技術問題以及HPV疫苗接種政策植根於內部的政治動態。政治和衛生體系不同，利益相關者的結構、政策過程的參與度以及他們的權力水準、潛在的價值標準和倫理觀點也不同，這為兩地政策可行性上的差異提供了合理解釋。然而，提高可行性可使用相同的政策工具，包括市場和規劃手段的混合使用，將問題推向立法程式以及循證政策制定，以達到共同的目標—合理治理。Chen, Ruirui.Thesis Ph.D. Chinese University of Hong Kong 2018.Includes bibliographical references (leaves 150-167).Abstract also in Chinese; appendix III, IV in Chinese.Title from PDF title page (viewed on …).Chen, Ruirui
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